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A nano-platform for diagnosis and treatment integration, preparation method and application thereof

A platform and nanotechnology, applied in the field of integrated diagnosis and treatment nanoplatform and its preparation, can solve the problems of reliability, stability and maturity yet to be verified, single means, and differences in the reliability, stability and maturity of curative effect, etc.

Active Publication Date: 2021-09-10
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, in the above-mentioned patented technical solution, two kinds of nanoparticles are used for compounding, and the stability of the material is poor, and it is suitable for emerging photothermal compound therapy, and its reliability, stability and maturity have yet to be verified; There are significant differences in the reliability, stability and maturity of the curative effect of rod composite nanoparticle photothermal therapy compared with phototherapy and chemotherapy composite therapy
[0008] In view of the current clinical problems of independent cancer diagnosis and treatment, long treatment cycle, high cost, single means, and large toxic and side effects, as well as the unstable performance and unreliable curative effect of materials used in existing photothermal therapy, in order to improve the therapeutic effect , reduce toxic and side effects, etc., the present application researches a kind of nano-particles as the main body, linking small organic molecules through chemical bonds, which has stronger stability and smaller overall size, which is conducive to treatment and excretion from the body, thus combining imaging with two The combination of modalities and treatments to prepare a new type of nanocomposite material with good stability and high efficacy and reliability for the integration of diagnosis and treatment has become a new direction for cancer treatment

Method used

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  • A nano-platform for diagnosis and treatment integration, preparation method and application thereof
  • A nano-platform for diagnosis and treatment integration, preparation method and application thereof
  • A nano-platform for diagnosis and treatment integration, preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0042] The preparation method of the integrated nano-platform for diagnosis and treatment based on fullerene, doxorubicin hydrochloride and rare earth thulium-doped upconversion luminescent nanocrystal provided in this example includes the following steps:

[0043] (1) the oil-soluble NaYF 4 : Yb, Tm are dispersed in cyclohexane, add acidic aqueous solution of pH = 3-5, react at room temperature for 4-5 hours to remove oleic acid ligand, modify it into water-soluble nanocrystals, centrifuge, wash, and take the solid Disperse in water, then add citric acid to the above solution, stir at room temperature for 12 hours, then centrifuge and wash to obtain citric acid-modified water-soluble rare earth up-transfer luminescent nanocrystals, take the solid and disperse it in water, add amino Modified fullerene (C60), add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) while stirring , stirred at room temperature for 12 hours, then centr...

Embodiment 2

[0052] The integrated nano-platform for diagnosis and treatment and its preparation method based on fullerene, doxorubicin hydrochloride and rare earth thulium and erbium co-doped up-conversion luminescent nanocrystals provided in this example are basically the same as those in Example 1. The difference is that it includes the following steps:

[0053] (1) the oil-soluble NaYF 4 : Yb, Tm, Er are dispersed in cyclohexane, adding an acidic aqueous solution of pH = 3-5, reacting at room temperature for 4-5 hours to remove the oleic acid ligand, modifying it into a water-soluble nanocrystal, centrifuging, washing, Take the solid and disperse it in water, then add citric acid to the above solution, stir well at room temperature for 12 hours, then centrifuge and wash to obtain the citric acid-modified water-soluble rare earth up-transfer luminescent nanocrystal, take the solid and disperse it in water, Amino-modified fullerene (C60) was added, and 1-(3-dimethylaminopropyl)-3-ethylc...

Embodiment 3

[0060] This embodiment provides fullerene, doxorubicin hydrochloride and surface coated with inert NaYF 4 The rare earth thulium-doped up-conversion luminescent nanocrystal is the main body of the integrated nano-platform for diagnosis and treatment and its preparation method, which is basically the same as that of Examples 1 and 2, except that it includes the following steps:

[0061] (1) the oil-soluble NaYF 4 :Yb,Tm@NaYF 4 Disperse in cyclohexane, add acidic aqueous solution with pH = 3-5, react at room temperature for 4-5 hours to remove oleic acid ligands, modify them into water-soluble nanocrystals, centrifuge and wash, take the solids and disperse them in water, Then add citric acid to the above solution, stir well at room temperature for 12 hours, then centrifuge and wash to obtain citric acid-modified water-soluble rare earth up-transfer luminescent nanocrystals, take the solid and disperse it in water, add amino-modified fullerene Alkene (C60), while stirring, add 1-...

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Abstract

The invention discloses a diagnosis and treatment integrated nanometer platform and a preparation method, which are mainly based on fullerene, doxorubicin hydrochloride and rare earth up-conversion luminescent nanocrystals. Lene (C60) was modified on the surface of rare earth upconversion luminescent nanocrystals, followed by the introduction of dithioglycolic acid to improve water solubility and glutathione response release function, and then combined with the chemotherapy drug doxorubicin hydrochloride, And the host-guest self-assembly of the formed nano-platform and folic acid-modified β-cyclodextrin is carried out to make it have specific targeting and further improve its water solubility, that is, to obtain the integrated nano-platform for diagnosis and treatment, which can be used for optical imaging-guided Photodynamic and specifically targeted drug release dual modality therapy. The present invention has good stability and strong targeting, and has the function of synergistic treatment of two modes, can perform precise fixed-point drug administration, and meets the needs of clinical diagnosis and treatment integration.

Description

technical field [0001] The invention relates to the technical field of manufacturing nano-biological materials, in particular to a nano-platform for integrated diagnosis and treatment based on fullerenes, doxorubicin hydrochloride and rare earth up-conversion luminescent nanocrystals as the main body, as well as its preparation method and application. Background technique [0002] Fullerene: the photosensitizer described in the photosensitizer is zinc phthalocyanine, fullerene, rose bengal, methylene blue or chlorin. [0003] More than a century later, cancer is one of the number one "killers" threatening human life and health. This threat mainly comes from two aspects: the difficulty of early diagnosis of cancer and the limitation of clinical treatment methods. Due to the untimely diagnosis and treatment of cancer in the early stage, most of the patients receiving cancer treatment are in the middle and advanced stages. At present, the main methods used in clinical treatme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K41/00A61K31/704A61K47/55A61K47/54A61K47/69A61P35/00
CPCA61K31/704A61K41/0057A61K49/0019A61K49/0054A61K47/545A61K47/55A61K47/6951A61P35/00A61K2300/00
Inventor 孙丽宁张强施利毅王卓孙松强
Owner SHANGHAI UNIV
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