Hyaluronic acid buccal tablet and preparation method thereof

Abstract

The invention provides a hyaluronic acid buccal tablet and a preparation method thereof. The hyaluronic acid buccal tablet is prepared from the following raw materials in parts by weight: 0.2-6.5 parts of high-molecular-weight hyaluronic acid or salt thereof, 0.15-10 parts of low-molecular-weight hyaluronic acid or salt thereof, 6-15 parts of erythritol, 1.5-7.5 parts of inositol, 25-40 parts of maltodextrin, 20-30 parts of mannitol, 1-2 parts of carboxymethyl cellulose sodium and 1-2 parts of magnesium stearate.

Description

technical field

[0001] The invention belongs to the field of health food and relates to a preparation method of hyaluronic acid buccal tablets. Background technique

[0002] With climate change, some throat diseases have begun to plague people's lives, such as dry mouth, dry throat, sore throat, etc. These chronic diseases seem to have little impact, but they have brought great impact to people's life and work. Inconvenience, and keeping the mouth and throat moist can effectively alleviate the discomfort caused by such chronic diseases, so hyaluronic acid, known as the "natural moisturizing factor", has become the first choice.

[0003] Hyaluronic acid (HA) is an acidic mucopolysaccharide. It is colorless and tasteless. It is non-irritating when taken. It usually exists in the form of sodium salt. Different molecular weight HA can show different effects. Among them, high molecular weight HA or its salt can be A layer of barrier is formed on the surface of oral mucosa and re...

Examples

preparation example Construction

[0086] This paper also relates to a preparation method of the above-mentioned hyaluronic acid buccal tablet, which is characterized in that: comprising the following steps: adding high molecular weight hyaluronic acid or its salt, low molecular weight hyaluronic acid or its salt, erythritol, inositol , maltodextrin, mannitol, and sodium hydroxymethylcellulose are mixed uniformly; the above-mentioned mixture is uniformly mixed and dissolved by adding water to granulate with an extrusion granulator, then magnesium stearate is added, and the mixture is uniformly mixed again. drying and sieving; compressing the dried and sieved mixed granules to obtain buccal tablets; sterilizing the buccal tablets; sealing and packaging the sterilized buccal tablets. In the method herein, any device can be used as long as it can realize the above steps.

[0087] In addition, in the first step, high molecular weight hyaluronic acid or its salt, low molecular weight hyaluronic acid or its salt, ery...

Embodiment 1

[0092] (1) Raw material pretreatment

[0093] Take 0.2 parts of 2000kDa sodium hyaluronate, 7 parts of 1kDa sodium hyaluronate, 2.5 parts of 5kDa zinc hyaluronate, 15 parts of erythritol, 1.5 parts of inositol, 25 parts of maltodextrin, 20 parts of mannitol, hydroxymethyl Mix 2 parts of sodium cellulose base evenly.

[0094] (2) Granulation

[0095]Add 10g of purified water to the homogeneously mixed raw materials in step (1), use an extrusion granulator to granulate, dry in an oven at 40-50°C for 2 hours, pass through a 12-14 mesh sieve to crush large particles, and then pass through a 60 Mesh sieve to remove fine particles and fine powder;

[0096] (3) Tablet

[0097] Add 1 part of magnesium stearate to the above-mentioned granules, mix again uniformly to obtain a mixture, and perform tablet compression with an extrusion tablet machine, controlling the weight of a single tablet to 500 mg, and the resulting compressed tablet is named S1.

Embodiment 2

[0099] Take 1 part of 1600kDa sodium hyaluronate, 5 parts of 2kDa sodium hyaluronate, 2.5 parts of 3kDa zinc hyaluronate, 12 parts of erythritol, 2 parts of inositol, 30 parts of maltodextrin, 27 parts of mannitol, hydroxymethyl 1.8 parts of cellulose sodium were mixed evenly.

[0100] (2) Granulation

[0101] Add 10g of purified water to the homogeneously mixed raw materials in step (1), use an extrusion granulator to granulate, dry in an oven at 40-50°C for 2 hours, pass through a 12-14 mesh sieve to crush large particles, and then pass through a 60 Mesh sieve to remove fine particles and fine powder;

[0102] (3) Tablet

[0103] Add 1.4 parts of magnesium stearate to the above-mentioned granules, mix again uniformly to obtain a mixture, and compress the tablet with an extrusion tablet machine, and control the mass of a single tablet to 500 mg, and the resulting compressed tablet is named S2.

technical field

[0001] The invention belongs to the field of health food and relates to a preparation method of hyaluronic acid buccal tablets. Background technique

[0002] With climate change, some throat diseases have begun to plague people's lives, such as dry mouth, dry throat, sore throat, etc. These chronic diseases seem to have little impact, but they have brought great impact to people's life and work. Inconvenience, and keeping the mouth and throat moist can effectively alleviate the discomfort caused by such chronic diseases, so hyaluronic acid, known as the "natural moisturizing factor", has become the first choice.

[0003] Hyaluronic acid (HA) is an acidic mucopolysaccharide. It is colorless and tasteless. It is non-irritating when taken. It usually exists in the form of sodium salt. Different molecular weight HA can show different effects. Among them, high molecular weight HA or its salt can be A layer of barrier is formed on the surface of oral mucosa and re...

Examples

preparation example Construction

[0086] This paper also relates to a preparation method of the above-mentioned hyaluronic acid buccal tablet, which is characterized in that: comprising the following steps: adding high molecular weight hyaluronic acid or its salt, low molecular weight hyaluronic acid or its salt, erythritol, inositol , maltodextrin, mannitol, and sodium hydroxymethylcellulose are mixed uniformly; the above-mentioned mixture is uniformly mixed and dissolved by adding water to granulate with an extrusion granulator, then magnesium stearate is added, and the mixture is uniformly mixed again. drying and sieving; compressing the dried and sieved mixed granules to obtain buccal tablets; sterilizing the buccal tablets; sealing and packaging the sterilized buccal tablets. In the method herein, any device can be used as long as it can realize the above steps.

[0087] In addition, in the first step, high molecular weight hyaluronic acid or its salt, low molecular weight hyaluronic acid or its salt, ery...

Embodiment 1

[0092] (1) Raw material pretreatment

[0093] Take 0.2 parts of 2000kDa sodium hyaluronate, 7 parts of 1kDa sodium hyaluronate, 2.5 parts of 5kDa zinc hyaluronate, 15 parts of erythritol, 1.5 parts of inositol, 25 parts of maltodextrin, 20 parts of mannitol, hydroxymethyl Mix 2 parts of sodium cellulose base evenly.

[0094] (2) Granulation

[0095]Add 10g of purified water to the homogeneously mixed raw materials in step (1), use an extrusion granulator to granulate, dry in an oven at 40-50°C for 2 hours, pass through a 12-14 mesh sieve to crush large particles, and then pass through a 60 Mesh sieve to remove fine particles and fine powder;

[0096] (3) Tablet

[0097] Add 1 part of magnesium stearate to the above-mentioned granules, mix again uniformly to obtain a mixture, and perform tablet compression with an extrusion tablet machine, controlling the weight of a single tablet to 500 mg, and the resulting compressed tablet is named S1.

Embodiment 2

[0099] Take 1 part of 1600kDa sodium hyaluronate, 5 parts of 2kDa sodium hyaluronate, 2.5 parts of 3kDa zinc hyaluronate, 12 parts of erythritol, 2 parts of inositol, 30 parts of maltodextrin, 27 parts of mannitol, hydroxymethyl 1.8 parts of cellulose sodium were mixed evenly.

[0100] (2) Granulation

[0101] Add 10g of purified water to the homogeneously mixed raw materials in step (1), use an extrusion granulator to granulate, dry in an oven at 40-50°C for 2 hours, pass through a 12-14 mesh sieve to crush large particles, and then pass through a 60 Mesh sieve to remove fine particles and fine powder;

[0102] (3) Tablet

[0103] Add 1.4 parts of magnesium stearate to the above-mentioned granules, mix again uniformly to obtain a mixture, and compress the tablet with an extrusion tablet machine, and control the mass of a single tablet to 500 mg, and the resulting compressed tablet is named S2.

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