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Kidney-protecting bee mixture formula and application thereof

A bee mixture and formula technology, applied in the field of kidney protection, can solve problems such as no innovative application of bee mixture, no in-depth technological innovation of bee pupae medicinal or protective effect, etc., and achieve good protective effect, increase vitality, and strong antioxidant activity. Effect

Pending Publication Date: 2020-04-07
普洱学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the existing technology is aimed at the preparation of bee pupa dry powder, the processing method of eating, the production of wine and health wine, there is no technology that has carried out in-depth technological innovation on the medicinal or protective effect of bee pupa, let alone the innovation of this kind of bee mixture application

Method used

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  • Kidney-protecting bee mixture formula and application thereof
  • Kidney-protecting bee mixture formula and application thereof
  • Kidney-protecting bee mixture formula and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of bee pupae extract

[0022] Use a syringe to absorb the tissue liquid of bee pupae, homogenize it with a glass homogenizer, and ultrasonically disrupt the cells at a voltage of 150V for 25 minutes, and then centrifuge at a speed of 13000rpm / min for 13 minutes; take the supernatant, press petroleum Ether: bee pupa = 1:2 ratio Mix petroleum ether and bee pupa, mix on a vortex shaker for 4 minutes, centrifuge at a speed of 13000rpm / min for 8 minutes, take the supernatant repeatedly--oscillate-- Centrifuge step until completely skimmed. All the above operations need to be carried out on ice; after the degreasing is complete, freeze-dried powder is made in a vacuum freeze dryer, packed in centrifuge tubes, sealed tightly with parafilm, and stored in a -80°C refrigerator for future use.

[0023] (2) Preparation of animal models

[0024] Forty-two eight-week-old mice of similar body weight were randomly divided into five groups, 6 in each group. Blank cont...

Embodiment 2

[0041] A kidney-protecting bee mixture formula, the raw materials and weight parts of the bee mixture formula are 20 parts by weight of bee pupa extract, 8 parts by weight of honey, and 12 parts by weight of royal jelly; The auxiliary material is prepared as oral liquid, capsule, tablet or freeze-dried powder.

[0042] The bee pupa extract is prepared by the following method: absorb the bee pupa tissue liquid, homogenize it with a glass homogenizer, and ultrasonically break the cells for 20 minutes under the condition of a voltage of 150V, and then under the condition of a speed of 12000rpm / min Centrifuge for 10 min; take the supernatant, mix petroleum ether and bee pupa according to the ratio of petroleum ether: bee pupa = 1:2, mix on a vortex shaker for 3 min, and centrifuge for 5 min at a speed of 12000 rpm / min. Repeat the steps of taking the supernatant-oscillation-centrifugation until it is completely degreased; the above operations must be performed on ice; after the deg...

Embodiment 3

[0045] A kidney-protecting bee mixture formula, the raw materials and parts by weight of the bee mixture formula are 23 parts by weight of bee pupa extract, 9 parts by weight of honey, and 13 parts by weight of royal jelly; The auxiliary material is prepared as oral liquid, capsule, tablet or freeze-dried powder.

[0046] The honeybee pupae extract is prepared by the following method: absorb the honeybee pupae tissue liquid, homogenize it with a glass homogenizer, and ultrasonically break the cells for 30 minutes under the condition of a voltage of 150V, and then under the condition of a speed of 14000rpm / min Centrifuge for 15 min; take the supernatant, mix petroleum ether and bee pupa according to the ratio of petroleum ether: bee pupa = 1:2, mix on a vortex shaker for 5 min, and centrifuge for 10 min at a speed of 14000 rpm / min. Repeat the steps of taking the supernatant-oscillation-centrifugation until it is completely degreased; the above operations must be performed on ic...

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Abstract

The invention, which belongs to the technical field of kidney protection, discloses a kidney-protecting bee mixture formula and application thereof. The bee mixture formula comprises the following rawmaterials, by weight: 20 to 25 parts of bee pupa extract, 8 to 10 parts of honey and 12 to 15 parts of royal jelly. According to the bee product mixture formula, glutathione consumption can be reduced, antioxidant enzyme activity can be improved, creatinine and urea nitrogen levels in blood and urine can be reduced, so that the kidney is well protected. The bee mixture enables the effect to be obviously improved by being compared with single use of bee products.

Description

technical field [0001] The invention relates to a kidney-protecting bee mixture formula and application thereof, belonging to the technical field of kidney protection. Background technique [0002] The kidney is the main organ for the body to eliminate metabolic waste, so the rapid deterioration of kidney function in a short period of time will have a serious impact on the human body. The causes of kidney injury are: mechanical factors (firearm injury, stab wound, etc.), blood factors (blood flow reduction, ischemia-reperfusion, etc.) and drug factors (anti-infection, immunosuppressant, and anti-tumor drugs, etc.). Cisplatin is one of the anticancer drugs that can cause acute kidney injury. Cisplatin, namely cis-dichlorodiammine platinum II (Cisplatin), was discovered in 1965. It is widely used for its broad-spectrum anti-cancer, strong effect, synergy with various anti-tumor drugs and no cross-resistance. In the treatment of solid tumors, its efficacy and nephrotoxicity a...

Claims

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Application Information

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IPC IPC(8): A61K35/644A61K35/64A61P13/12
CPCA61K35/644A61K35/64A61P13/12A61K2300/00
Inventor 赵锋熊潇然赵芳
Owner 普洱学院
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