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Gold-platinum bimetallic nanoparticles and preparation method thereof

A bimetallic nano-particle technology, applied in the field of nano-particles, can solve the problems of unfavorable biomedical applications, poor biocompatibility, long reaction time, etc., and achieve the effects of environmental friendliness, short reaction time and simple reaction conditions

Active Publication Date: 2020-04-10
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]The common chemical reduction method of precious metal nanoparticles often uses toxic and harmful chemical reducing agents, and the reaction time is long, easy to agglomerate, and additional stabilizers are required
Poor biocompatibility is not conducive to the application in biomedicine

Method used

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  • Gold-platinum bimetallic nanoparticles and preparation method thereof
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  • Gold-platinum bimetallic nanoparticles and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] An embodiment of the gold-platinum bimetallic nanoparticles described in the present invention, the preparation process of the gold-platinum bimetallic nanoparticles described in this embodiment is as follows:

[0046] Experimental materials: 10mmol / l chlorogenic acid solution, 3mmol / l chloroauric acid solution, 2.718mmol / l chloroplatinic acid solution;

[0047] experiment procedure:

[0048]After the hot plate is preheated for 30 minutes, take 600 μl of chlorogenic acid solution in the sample bottle, heat it on the hot plate without a cover for about 2 minutes, then add dropwise 600 μl of a mixed solution of equal volumes of chloroauric acid and chloroplatinic acid, and heat for about 1 minute , the color changes (light brown just after the dropwise addition, and the color gradually deepens during the heating process), the reaction temperature is 80-95 ° C, after heating, the solution is clear and transparent after cooling to room temperature, and it is brown; the actu...

Embodiment 2

[0051] An embodiment of the gold-platinum bimetallic nanoparticles of the present invention, this embodiment specifically analyzes the reaction concentration of chlorogenic acid in the preparation process of the gold-platinum bimetallic nanoparticles and the reaction sequence in the preparation process.

[0052] Prepare 1mmol / L chlorogenic acid aqueous solution, 1mmol / L chloroauric acid aqueous solution, and 1mmol / L chloroplatinic acid aqueous solution; mix the chlorogenic acid aqueous solution, chloroplatinic acid aqueous solution and water, heat in a constant temperature water bath at 95°C for 150min, then heat Stir on the device and heat to boiling, then heat and react with chloroauric acid solution to boiling. The control actual reaction concentration of chloroauric acid is 0.1mmol / L; chloroplatinic acid is 0.1mmol / L; chlorogenic acid is 0.1mmol / L, 0.2mmol / L, 0.3mmol / L, 0.4mmol / L, the reaction concentration (Chloroauric acid: chloroplatinic acid: chlorogenic acid) is 1:1:1...

Embodiment 3

[0055] An embodiment of the gold-platinum bimetallic nanoparticles described in the present invention. This embodiment specifically describes the reaction concentration of chloroplatinic acid and chloroauric acid in the preparation process of Au@Pt bimetallic nanoparticles and the reaction sequence in the preparation process. analyze.

[0056] Mix chlorogenic acid solution, chloroplatinic acid solution and water in a water bath at 95°C for 80 minutes, stir and heat on a heater until boiling, then add chloroauric acid solution and heat to boiling, and control the actual reaction concentration of chloroauric acid to 0.1mmol / L; chloroplatinic acid 0.2mmol / L, 0.4mmol / L, 0.8mmol / L; chlorogenic acid 2.5mmol / L. Then the reaction concentration ratio (chloroauric acid: chloroplatinic acid: chlorogenic acid) is 1:2:25, 1:4:25, 1:8:25 respectively. Its TEM images are as follows Figure 14 , 15 , 16, it can be seen that the prepared bimetallic nanoparticles have good dispersibility, b...

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Abstract

The invention discloses a preparation method of gold-platinum (Au@Pt) bimetallic nanoparticles. The preparation method comprises the steps of enabling a chlorogenic acid aqueous solution to react witha chloroplatinic acid aqueous solution and a chloroauric acid aqueous solution at 80-100 DEG C, and obtaining the gold-platinum bimetallic nanoparticles. The green preparation method of the Au@Pt bimetallic nanoparticles is efficient and rapid. The preparation method adopts biologically active chlorogenic acid as a reducing agent and avoids the use of reducing agents with higher toxicity such assodium borohydride and the like. The preparation method does not need additional stabilizers or protective agents, and is simple and environmental-friendly in reaction conditions and short in reactiontime. The prepared Au@Pt bimetallic nanoparticles have good dispersibility, good scavenging effect on DPPH free radicals, good oxidation resistance and potential medical applicability.

Description

technical field [0001] The invention relates to a nano particle, in particular to a gold-platinum bimetallic nano particle and a preparation method thereof. Background technique [0002] Compared with single metal nanomaterials, bimetallic nanomaterials are a new class of advanced materials with unique charm, which can integrate two or more different functional nanomaterials into a whole to obtain more excellent performance and even is new performance. [0003] The common forms of bimetallic NPs are core-shell, heterostructure and alloy nanostructure. The most common bimetallic nanoparticles are made of noble metals, such as Au@Ag, Au@Pd, Au@Pt, etc., and their performance and nanoparticle The structure and size are closely related. [0004] Platinum nanostructures with high surface area combined with other metal nanoparticles have been used as antitumor drugs in biomedicine. The development of bimetallic nanomaterials based on platinum is an area of ​​current research in...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/00
CPCB22F9/24B22F2009/245B22F1/07B22F1/054Y02E60/50
Inventor 陈榕
Owner HAINAN MEDICAL COLLEGE
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