Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal Tamarix chinensis extract and application thereof

An extract, the technology of Tamarix, applied in the field of medicinal Tamarix extract, can solve the problems of large side effects, increased risk of cardiovascular disease and bladder cancer, low efficacy of intervention in prediabetes, etc., and achieve the effect of reducing the rise of blood sugar

Inactive Publication Date: 2020-04-17
SHANDONG UNIV OF TECH
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, relatively speaking, thiazolidinediones have certain liver toxicity and increase the risk of cardiovascular disease and bladder cancer. At the same time, they are not suitable for patients with blood lipid disorders, and their application is greatly restricted.
Because most of the existing drugs have the disadvantages of low efficacy in prediabetes intervention or large side effects, it is more urgent to develop anti-prediabetic drugs with high efficiency and low toxicity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal Tamarix chinensis extract and application thereof
  • Medicinal Tamarix chinensis extract and application thereof
  • Medicinal Tamarix chinensis extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of Medicinal Tamarix Extract:

[0026] S1. Take 100 g of Tamarix leaves, put them in a portable DFT-200 high-speed rotary traditional Chinese medicine grinder, and grind for 20 seconds, 5 times in total. After pulverization, put it in 1.5L ethanol aqueous solution for 2 days, remove the plant residue with 3 layers of filter paper, and obtain the plant ethanol aqueous extract;

[0027] S2. Remove most of the filtrate from the obtained vegetable ethanol water extract with a vacuum rotary evaporator to obtain an oily liquid;

[0028] S3. Add an appropriate amount of petroleum ether to the oily liquid, mix well, let stand, centrifuge at 7500g for 10 minutes, discard the petroleum ether liquid, redissolve the precipitate in absolute ethanol, and evaporate to dryness to obtain the extract powder.

[0029] In the following examples: the standard basal feed was purchased from Changzhou Shuyishuer Biotechnology Co., Ltd., and the butter was purchased from Maggie Lin...

Embodiment 2

[0031] Study on the effect of medicinal Tamarix extract in treating diabetes and prediabetes and their complications

[0032] (1) Establishment of mouse models of diabetes and prediabetes

[0033]Get body weight and be 16-20g Kunming mice, adapt to the environment after 3 days, feed the water of high-fat high-sugar food (36.4% starch, 25.6% butter, 20% albumen, 1% cholesterol and 0.1% bile acid) and 3% sucrose, After 5 weeks of diet-induced insulin resistance, 60 mg / kg STZ was injected into the tail vein. Oral glucose tolerance tests were performed on the 7th and 21st days after injection. The mice whose blood glucose was 11.1 mM or higher 2 hours after the meal were diabetic mice (DM mice).

[0034] Get body weight and be 16-20g Kunming mice, adapt to the environment after 3 days, feed the water of high-fat high-sugar food (36.4% starch, 25.6% butter, 20% albumen, 1% cholesterol and 0.1% bile acid) and 3% sucrose, After 5 weeks of diet-induced insulin resistance, 15 mg / kg ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a medicinal Tamarix chinensis extract. The extract can be used for effectively treating diabetes mellitus, prediabetes mellitus and complications thereof, and treating non-alcoholic fatty liver and atherosclerosis, and the medicinal Tamarix chinensis extract can be compounded with acarbose to synergistically reduce the rise of postprandial blood sugar. The medicinal Tamarixchinensis extract is prepared through the following steps: S1, taking 100 g of Tamarix chinensis leaves, putting the Tamarix chinensis leaves into a portable DFT-200 high-speed rotating traditional Chinese medicine crusher, crushing the leaves for 20 seconds for five times, putting the crushed Tamarix chinensis leaves into 1.5 L of an ethanol-water solution for 2 days, and removing plant residuesby using three layers of filter paper to obtain a plant ethanol-water extract; S2, removing most of the filtrate from the obtained plant ethanol-water extract liquid by using a vacuum rotary evaporator to obtain an oily liquid; and S3, adding a proper amount of petroleum ether into the oily liquid, uniformly mixing, standing, centrifuging at 7500 g for 10 min, discarding the petroleum ether liquid, re-dissolving the obtained precipitate into anhydrous ethanol, and drying by distillation to obtain extract powder.

Description

technical field [0001] The invention relates to the field of medicinal preparations, in particular to a medicinal tamarisk extract and application thereof. Background technique [0002] With the improvement of people's living standards and the accelerating pace of life in modern society, high-fat fried food and sedentary life have become the daily life of a high proportion of people, and a series of diseases induced by high-fat diet have become a serious threat One of the main factors of human health. A long-term high-fat diet can easily cause a series of diseases such as hyperlipidemia, non-alcoholic fatty liver and atherosclerosis. According to the survey, there are 180 million adults with lipid metabolism disorders induced by high-fat diet in my country. [0003] Long-term high-fat diet can easily induce hyperlipidemia. Its main feature is that the serum cholesterol level, triglyceride or both are higher than normal. Hyperlipidemia can easily induce cardiovascular and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/185A61P3/10A61P1/16A61P9/10A61K31/7036
CPCA61K36/185A61K31/7036A61P3/10A61P1/16A61P9/10A61K2236/15A61K2236/333A61K2236/53A61K2300/00
Inventor 纪洪芳申亮孙文龙
Owner SHANDONG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com