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Self-healing hydrogel and preparation method thereof

A hydrogel, self-healing technology, applied in pharmaceutical formulations, drug combinations, photodynamic therapy, etc., can solve the problem that hydrogel particles do not have self-healing properties, and achieve good self-healing and stability. Good, small volume change effect

Active Publication Date: 2020-04-17
武汉华卫科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage of this method is that the prepared hydrogel particles do not have self-healing properties.

Method used

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  • Self-healing hydrogel and preparation method thereof
  • Self-healing hydrogel and preparation method thereof
  • Self-healing hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0033] see figure 1 Shown, the invention provides a kind of preparation method of self-healing hydrogel, comprises the steps:

[0034] S1, preparation of aldylated sodium hyaluronate: add sodium hyaluronate to deionized water according to a preset mass ratio, and stir evenly to obtain an aqueous solution of sodium hyaluronate; then add sodium periodate to the hyaluronic acid Sodium aqueous solution to obtain a first mixed solution; the first mixed solution is sequentially subjected to aldylation reaction, dialysis and freeze-drying to obtain aldylated sodium hyaluronate;

[0035] S2. Preparation of carbazole-modified sodium hyaluronate: add sodium hyaluronate to an aprotic solvent according to a preset volume ratio, and stir evenly to obtain a sodium hyaluronate solution; According to the first preset molar ratio, add carbazole to the said aldylated sodium hyaluronate solution and stir evenly to obtain the second mixed solution; Adding an activator and a co-agent, adjusting ...

Embodiment 1

[0050] Please refer to figure 1 Shown, a kind of preparation method of self-healing hydrogel:

[0051] S1, the preparation of formylated hyaluronic acid:

[0052] Put sodium hyaluronate in deionized water, the mass-volume ratio of sodium hyaluronate to deionized water is 100, stir at room temperature for 6 hours to form a sodium hyaluronate aqueous solution, and add periodiodine to the sodium hyaluronate aqueous solution The first mixed solution of sodium hyaluronate was prepared, wherein the molar ratio of the hydroxyl group on the molecular chain of sodium hyaluronate to sodium periodate was 1:5, stirred evenly at room temperature, and reacted at 40°C for 12 hour, the reacted sodium hyaluronate and sodium periodate mixed solution were dialyzed, and the dialysis time was 2 days to obtain an aldylated sodium hyaluronate solution, which was placed at a temperature of - Under the conditions of 50° C. and a pressure of 10 MPa, freeze-dry for 48 hours to obtain an aldylated sodi...

Embodiment 2-4

[0064] The difference from Example 1 is that in step S1, the molar ratio of the hydroxyl group on the sodium hyaluronate molecular chain to sodium periodate is different, and other steps are the same as in Example 1, and will not be repeated here.

[0065] Table 1 is the mol ratio setting of the hydroxyl group on the sodium hyaluronate molecular chain and sodium periodate in embodiment 1-4

[0066]

[0067]

[0068] Example 1-4 is illustrated in conjunction with Table 1: the effect of the change in the molar ratio of the hydroxyl group on the sodium hyaluronate molecular chain to sodium periodate on the molar substitution degree of the aldehyde group is: within a certain range, the oxidizing agent periodate The larger the sodium ratio, the higher the degree of oxidation of sodium hyaluronate, and the greater the degree of formylation modification of sodium hyaluronate.

[0069] The synthetic process of aldylated sodium hyaluronate is as follows:

[0070]

[0071] The...

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Abstract

The invention provides a self-healing hydrogel and a preparation method thereof. The self-healing hydrogel is composed of carbazole modified aldehyde sodium hyaluronate, hydrazide sodium hyaluronate and deionized water, and the strength of the self-healing hydrogel ranges from 1000 cps to 100000 cps. The preparation method of the self-healing hydrogel provided by the invention comprises the following steps: preparing a first mixed solution of sodium hyaluronate, deionized water and sodium periodate, and carrying out aldehyde reaction to obtain aldehyde sodium hyaluronate; then, preparing a second mixed solution of aldehyde sodium hyaluronate, an aprotic solvent and carbazole, adding an activating agent and a sharing agent, adjusting the pH value, and carrying out carbazole grafting reaction to obtain carbazole modified grafted aldehyde sodium hyaluronate; and finally, uniformly mixing the prepared carbazole modified grafted aldehyde sodium hyaluronate, hydrazide sodium hyaluronate anddeionized water according to a preset proportion to obtain the self-healing hydrogel. The self-healing hydrogel prepared by the invention has excellent self-healing performance and biocompatibility, and also has special photoelectric characteristics.

Description

technical field [0001] The invention relates to the technical field of preparation of hydrogel materials, in particular to a self-healing hydrogel and a preparation method thereof. Background technique [0002] With the continuous development of science and technology, the medical field pays more and more attention to and is optimistic about non-drug treatment methods. Among many non-drug treatment methods, the use of light therapy to prevent and treat various human diseases has been widely used in clinical practice. [0003] The process of tissue repair is often accompanied by complications such as mucositis and periarthritis, which hinder tissue repair and bring great pain to patients. In order to solve this problem, light sources such as ultraviolet light, infrared light and visible light are used in medicine to treat various diseases including inflammation, tumor, cancer, depression and so on. Phototherapy is a physical therapy that uses the radiant energy of light (in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08J3/24C08J3/075C08B37/08A61K47/69A61K47/54A61K41/00A61P17/02A61K49/00A61L26/00
CPCC08J3/24C08J3/075C08B37/0072A61K47/6903A61K47/545A61K41/0057A61K41/0052A61P17/02A61K49/0021A61K49/0054A61K49/0073A61L26/008A61L26/0023A61L26/009C08J2305/08C08J2405/08A61L2300/41A61L2300/412A61L2300/204A61L2300/604C08L5/08
Inventor 周应山李尚志张梦帆刘欣杨红军顾绍金叶德展陶咏真徐卫林
Owner 武汉华卫科技有限公司
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