Unlock instant, AI-driven research and patent intelligence for your innovation.
Flower-like zinc phosphate nanoparticle antibacterial material and preparation method and application thereof
Active Publication Date: 2020-04-21
河北凯恩利生物技术有限公司
View PDF8 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0005] Chinese patent CN 108823964 A discloses a preparation method of zinc oxide-silver composite antibacterial cotton fabric, but the preparation time is long, silver powder needs to be added, the cost is high, and the requirements are relatively high
Chinese patent CN 109440524 A discloses a preparation method of antibacterial paper loaded with nano-zinc oxide, but the reaction temperature is high and the preparation time is long, which has become a concern that cannot be ignored
Chinese patent CN 105494434 A discloses the preparation method of zinc oxide antibacterial composite material, the preparation temperature is as high as 500°C, the preparation time is longer and the operating conditions are more demanding
Chinese patent CN 107252395 A discloses a composition containing zinc phosphate, and its preparation components are relatively complicated
The above technologies all have various problems such as harsh preparation conditions and high cost.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0060] Example 1 Preparation of antibacterial material of flower-like zinc phosphate nanoparticles controlled by isoorotic acid
[0061] Prepare flower-like zinc phosphate nanoparticles antibacterial material according to the following steps:
[0062] (1) Dissolve 50mg of 2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) in 25mL with a concentration of 0.01mol / LNa 2 HPO 4 ·12H 2 In O solution, make a composite solution;
[0063] (2) Adjust the pH value of the above solution to 8.0 with 2mol / L NaOH, until it is completely dissolved, and set aside;
[0064] (3) Take 8mL of the above solution into a 50mL centrifuge tube, add 0.8mL ultrapure water, and then add 0.3mol / L Zn(NO 3 ) 2 ·6H 2 3.2mL of O solution, let stand for 2h, centrifuge at 10000rpm for 5min, remove the supernatant, and wash with ultrapure water.
[0065] (4) Place the precipitate obtained in step (3) in a freeze-vacuum dryer at -45° C. and a pressure of 5 Pa. The freeze-drying time is 8 hours. The flower-shaped zin...
Embodiment 2
[0067] Example 2 Preparation of flower-like zinc phosphate nanoparticle antibacterial material regulated by isorotic acid
[0068] Prepare flower-like zinc phosphate nanoparticles antibacterial material according to the following steps:
[0069] (1) Dissolve 50mg of 2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) in 25mL with a concentration of 0.01mol / LNaH 2 PO 4 ·2H 2 In O solution, make a composite solution;
[0070] (2) Adjust the pH value of the above solution to 8.0 with 2mol / L NaOH, until it is completely dissolved, and set aside;
[0071] (3) Take 8mL of the above solution into a 50mL centrifuge tube, add 0.8mL ultrapure water, and then add 0.3mol / L Zn(NO 3 ) 2 ·6H 2 3.2mL of O solution, let stand for 2h, centrifuge at 10000rpm for 5min, remove the supernatant, and wash with ultrapure water.
[0072] (4) The precipitate obtained in step (3) is placed in a freeze-vacuum dryer at -45°C and a pressure of 1-10 Pa, and the freeze-drying time is 6-12 hours. The flower-like ...
Embodiment 3
[0074] Example 3 Preparation of antibacterial material of flower-like zinc phosphate nanoparticles controlled by isorotic acid
[0075] Prepare flower-like zinc phosphate nanoparticles antibacterial material according to the following steps:
[0076] (1) Dissolve 50mg of 2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) in 25mL with a concentration of 0.1mol / LNa 2 HPO 4 ·12H 2 In O solution, make a composite solution;
[0077] (2) Adjust the pH value of the above solution to 8.5 with 2mol / L NaOH, until it is completely dissolved, and set aside;
[0078] (3) Take 8mL of the above solution into a 50mL centrifuge tube, add 0.8mL ultrapure water, and then add 0.4mol / L Zn(NO 3 ) 2 ·6H 2 3.2mL of O solution, let stand for 2h, centrifuge at 10000rpm for 5min, remove the supernatant, and wash with ultrapure water.
[0079] (4) The precipitate obtained in step (3) is placed in a freeze-vacuum dryer at -45°C and a pressure of 1-10 Pa, and the freeze-drying time is 6-12 hours. The flower-...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
antibacterial rate
aaaaa
aaaaa
Login to View More
Abstract
The invention discloses a flower-like zincphosphatenanoparticle antibacterial material and a preparation method and application thereof, belonging to the technical field of anticorrosive materials.According to the preparation method, 2,4-dihydroxypyrimidine-5-carboxylic acid (isoorotic acid) is used for regulating and controlling a reaction of sodiumphosphate with zinc salt, a formed nano-particle material is separated out of a solution in a precipitate form, and the flower-like zincphosphate nano-particle antibacterial material is prepared through centrifugation, supernatant removal, washing and freeze drying. According to the antibacterial material prepared by the invention, the specific surface area of zinc phosphate is increased by a flower-shaped structure, so the antibacterial material can contact more microbial thalli, achieves a more obvious antibacterial effect and has good inhibition effects on Bacillus subtilis, Staphylococcus aureus, Salmonella enteritidis and a plurality of antibiotic-resistant strains; meanwhile, the material has the characteristics of low toxicity, small side effect, good biological safety and the like; and the preparation method has the advantages of simple preparation process, high operability and good market application prospects.
Description
Technical field [0001] The invention belongs to the technical field of antiseptic materials, and specifically relates to a flower-shaped zinc phosphate nano-particle antibacterial material and a preparation method and application thereof. Background technique [0002] In the past few decades, environmental pollution caused by pathogenic bacteria has threatened human health, posing unprecedented challenges to the research of sterilization and bacteriostasis. Therefore, it is very urgent to develop efficient and safe sterilization and antibacterial materials. Studies have found that some nanomaterials have antibacterial or bactericidal properties, which are different from other antibacterial agents. Nanomaterials exhibit better antibacterial effects due to their smaller size and larger surface area. [0003] Nano-zinc particle materials (common nano-zinc oxide) have been applied in many fields such as agriculture, chemistry, medicine and food. As a new type of inorganic antibacteri...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More