A kind of high-strength self-healing hydrogel based on modified hyaluronic acid and preparation method thereof

Abstract

The invention discloses a high-strength self-healing hydrogel based on modified hyaluronic acid and a preparation method thereof. prepared from raw materials. The invention has good biocompatibility by using all-natural polymer hyaluronic acid as the matrix; through the multiple dynamics of hydrazone bond and disulfide bond between maleic hydrazide hyaluronic acid and aldehyde hyaluronic acid Covalent bonding endows the hydrogel with good self-healing properties; then further photocrosslinking is used to perform secondary crosslinking on the hydrogel, so that the hydrogel has superior mechanical properties. Moreover, the present invention utilizes the characteristics of disulfide bonds, and does not need to add a photoinitiator during the photocrosslinking process, thereby avoiding the toxic damage caused by the photoinitiator to the organism. The hydrogel can be rapidly formed, thus avoiding the spreading of the gel solution in the living body.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a high-strength self-healing hydrogel based on modified hyaluronic acid and a preparation method thereof. Background technique [0002] In the treatment of cancer patients, the prevention of postoperative recurrence is very important. The current conventional treatment methods include adjuvant chemotherapy, endocrine therapy and radiotherapy, etc., but some accompanying toxic reactions and systemic side effects cannot be ignored. Since the recurrence of various types of tumors usually starts locally, such as breast tumors, it has been proposed in recent years to introduce bioscaffold materials (such as hydrogels, biofilms, etc.) loaded with functional molecules into tumor sites to achieve in situ killing of tumor cells, Therapeutic strategies to inhibit tumor recurrence. [0003] Hydrogel is an ideal tissue engineering repair material and has received extensive attent...

AI Technical Summary

Problems solved by technology

However, there are still some shortcomings in its application: first, in the complex in vivo environment, the hydrogel is easily affected by external stimuli, so it cannot function stably; second, the structural integrity of the hydrogel is easily damaged, and Partial fracture, which will affect the therapeutic effect and interfere with the repair of tissue space and the growth and differentiation of cells

However, the above-mentioned self-healing hydrogels are usually soft and brittle, and the mechanical strength and self-healing ability cannot meet the application requirements to a large extent, which makes them unable to be used for the replacement and repair of biological tissues under high loads, which limits their application. application

Moreover, the preparation process of the above self-healing hydrogel is complicated and expensive, which further limits its application.

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