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Two-dimensional nanocomposite, preparation method therefor and application of two-dimensional nanocomposite

A nano-composite material and nano-material technology are applied in the field of two-dimensional black bismuth oxyhalide nano-materials, which can solve the problems of many restrictions and shallow penetration depth, and achieve the effects of simple process, low cost and high yield.

Pending Publication Date: 2020-05-01
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Based on this, the inventors have studied the application of BiOCl nanosheets in photodynamic therapy of breast cancer, but because of their absorption in the ultraviolet region, the penetration depth of ultraviolet rays in organisms is shallow and they have certain phototoxicity, so they are not used in clinical applications. more restricted

Method used

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  • Two-dimensional nanocomposite, preparation method therefor and application of two-dimensional nanocomposite
  • Two-dimensional nanocomposite, preparation method therefor and application of two-dimensional nanocomposite
  • Two-dimensional nanocomposite, preparation method therefor and application of two-dimensional nanocomposite

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Experimental program
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Effect test

Embodiment 1

[0131] (1) Weigh 486mg Bi(NO 3 ) 3 ·5H 2 0. After mixing 400mgPVP and 455mg mannitol, dissolve it into 25mL of ultrapure water. After stirring the mixed solution for 10min, carry out ultrasonic treatment to make it evenly mixed, and then put it into an ultrasonic machine for ultrasonication for 10min to obtain solution a;

[0132] (2) Subsequently, in the process of continuous stirring, 5 mL of saturated NaCl solution was slowly added dropwise into the mixed solution through a syringe, and stirred while dropping. After the dropwise addition, a uniform white suspension b was obtained;

[0133] (3) The white suspension b was ultrasonically diffused again for 10 minutes, and then the mixed solution was transferred to a 50ml polytetrafluoroethylene hydrothermal reaction kettle, and then hydrothermally reacted at 160°C for 3 hours, and naturally cooled to leave a precipitate Use water and ethanol to clean 8 times in turn and dry to obtain white bismuth oxyhalide material c for l...

Embodiment 2

[0165] (1) Weigh 486mg Bi(NO 3 ) 3 ·5H 2 0. After mixing 400mgPVP and 455mg mannitol, dissolve it into 25mL of ultrapure water. After stirring the mixed solution for 10min, carry out ultrasonic treatment to make it evenly mixed, and then put it into an ultrasonic machine for ultrasonication for 10min to obtain solution a;

[0166] (2) Subsequently, in the process of continuous stirring, 5 mL of saturated NaCl solution was slowly added dropwise into the mixed solution through a syringe, and stirred while dropping, and a uniform white suspension b was obtained after the dropwise addition;

[0167] (3) The white suspension b was ultrasonically diffused again for 10 minutes, and then the mixed solution was transferred to a 50ml polytetrafluoroethylene hydrothermal reaction kettle, and then hydrothermally reacted at 180°C for 6 hours, and naturally cooled to leave a precipitate Use water and ethanol to clean 8 times in turn and dry to obtain white bismuth oxyhalide material c for...

Embodiment 3

[0174] (1) Weigh 972mg Bi(NO 3 ) 3 ·5H 2 O, 800mgPVP and 910mg mannitol are mixed and dissolved in 50mL of ultrapure water, and the mixed solution is stirred for 10min, then subjected to ultrasonic treatment to make it evenly mixed, and then placed in an ultrasonic machine for 10min to obtain solution a;

[0175] (2) Subsequently, in the process of continuous stirring, 10 mL of saturated NaCl solution was slowly added dropwise into the mixed solution through a syringe, and stirred while dropping. After the dropwise addition, it can be found that a uniform white suspension b has been formed;

[0176] (3) The white suspension b was ultrasonically diffused again for 10 minutes, and then the mixed solution was transferred to a 50ml polytetrafluoroethylene hydrothermal reaction kettle, and then hydrothermally reacted at 160°C for 9 hours, and naturally cooled to leave a precipitate Use water and ethanol to clean 8 times in turn and dry to obtain white bismuth oxyhalide material ...

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Abstract

The invention discloses a nanocomposite. The nanocomposite comprises black BiOX particles and an envelopment, wherein the envelopment is a biological compatible material; a photothermal conversion efficiency of the nanocomposite is not lower than 10%; and BiOX is at least one selected from BiOF, BiOCl, BiOBr, BiOI and BiOAt. The invention further discloses a preparation method for the nanocomposite and application of the nanocomposite. The nanocomposite is a two-dimensional black bismuth oxyhalide nano-material with an oxygen vacancy defect and is applied to photothermal therapy of tumors, andthus, a photothermal conversion material with wide absorption spectrum, high photothermal conversion efficiency and high molar extinction coefficient can be obtained; and by applying the nanocomposite to integration of diagnosis and treatment of the tumors, a diagnosis and treatment integrated reagent with good treatment effect and remarkable and excellent CT imaging performance can be obtained,identification and checkout on the tumors and serious diseases of heart and cerebral vessels, nervous systems, skeleton muscles and the like can be improved, and functions such as follow-up treatment,treatment effect following and prognosis evaluation during tumor treatment can also be achieved.

Description

technical field [0001] The invention relates to the field of materials, in particular to a two-dimensional black bismuth oxyhalide nanomaterial, its preparation method and its application. Background technique [0002] Malignant tumors have always been known as the number one killer of human health. According to incomplete statistics, 9.6 million patients die of cancer and 18.1 million new cases are diagnosed every year in the world. In view of the high risk and high mortality of cancer, researchers around the world have been working on developing more accurate and rapid diagnostic methods and treatments to fight cancer. Traditional cancer treatment includes chemotherapy, radiotherapy and surgery. In these traditional treatments, patients may suffer from severe side effects: chemotherapy and radiotherapy are less targeted and can cause serious damage to normal tissues and organs; Malignant tumors are helpless. The failure of these treatments has also given researchers an ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K9/50A61K47/10A61K47/32A61K47/36A61K47/42A61K49/04A61K51/02A61K51/12A61P35/00G01N23/046G01T1/161
CPCA61K9/5026A61K9/5031A61K9/5036A61K9/5052A61K9/5138A61K9/5146A61K9/5161A61K9/5169A61K41/0052A61K49/04A61K51/02A61K51/1265A61P35/00G01N23/046G01T1/161
Inventor 陈天翔房倩兰吴爱国徐裕
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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