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3,4-dammarane tetracyclic triterpenoid compound as well as extraction method and application thereof

A tetracyclic triterpene and cyclodammarane technology, applied in the research field of Cyclocarya paliurus, can solve the constraints of science, innovative drug development for a wide range of clinical applications, active ingredient tracking and system research lag, drug effect material basis and molecular action Mechanism research is not deep enough and other issues

Inactive Publication Date: 2020-05-05
CENT SOUTH UNIV +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current hypoglycemic research of Cyclocarya paliurus still focuses on simple crude extracts and extracts, and the research on biological activity is only some simple in vitro experiments. The tracking and systematic research on its active ingredients are far behind. The research on its molecular mechanism of action is not deep enough, which seriously restricts its more scientific and extensive clinical application and innovative drug research and development, and further research and elucidation are urgently needed.

Method used

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  • 3,4-dammarane tetracyclic triterpenoid compound as well as extraction method and application thereof
  • 3,4-dammarane tetracyclic triterpenoid compound as well as extraction method and application thereof
  • 3,4-dammarane tetracyclic triterpenoid compound as well as extraction method and application thereof

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Experimental program
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Embodiment

[0028] 1.1 Treatment of Cyclocarya paliurus medicinal material: Dry leaves of Cyclocarya paliurus (10Kg), grind and extract with 70% ethanol under reflux at 120°C (100L; 2×2h), concentrate at 60°C to obtain extract. The extract was further dispersed with water, extracted with dichloromethane, ethyl acetate, and n-butanol successively, 10 L each time, extracted 3 times, and the extract was concentrated at 60°C to obtain extract concentrates of different polar parts.

[0029] In this experiment, HPLC-DAD, TLC and UPLC-MS / MS methods were used to trace, analyze, separate and purify the dichloromethane extraction concentrate. The dichloromethane fraction was subjected to silica gel column chromatography CH 2 Cl 2 :CH 3 OH (100:1-0:100) gradient elution, 10% EtOH-H 2 SO 4 The TLC spots were developed for color development, observed under different bands of ultraviolet light and analyzed by HPLC-DAD, and concentrated and combined to obtain 9 parts (A-I). TLC thin-layer analysis ...

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Abstract

The invention discloses a 3,4-dammarane tetracyclic triterpenoid compound with the structural formula shown in formulas (1)-(4). The invention further discloses an extraction method and application ofthe 3,4-dammarane tetracyclic triterpenoid compound. The 3,4-dammarane tetracyclic triterpenoid compoundcan significantly increase the consumption of insulin resistance adipocyte glucose, inhibit generation of IR adipocyte FFA, reduce the content of free fatty acid in cells and activate PPAR<gamma> to a certain extent.

Description

technical field [0001] The invention relates to the research field of Cyclocarya paliurus, in particular to a 3,4-split ring dammarane type tetracyclic triterpene compound and an extraction method and application thereof. Background technique [0002] Cyclocarya paliurus (Bata1) Iljinsk belongs to the genus Cyclocarya paliurus (Bata1) Iljinsk, a dicotyledonous plant of the family Juglandaceae. It is very precious and is known as "the giant panda in the plant kingdom" and "the living fossil in the plant kingdom". Qingqian willow, also known as money willow, camellia, money tree, sweet tea tree, a string of money, etc., is only sporadically distributed in the south of the Yangtze River in my country. Authoritative classics such as "Dictionary of Medicinal Plants" and "Hunan Drug Records" have recorded that Cyclocarya paliurus is used for the treatment of diabetes, hyperlipidemia, hypertension, arthralgia, neurasthenia and other diseases; many modern pharmacological studies hav...

Claims

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Application Information

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IPC IPC(8): C07H15/24C07H1/08A61K31/704A61P3/10A61P3/06A61P9/12A61P19/02A61P25/20A61P25/00
CPCA61K31/704A61P3/06A61P3/10A61P9/12A61P19/02A61P25/00A61P25/20C07H1/08C07H15/24
Inventor 徐康平孙惠惠李静谭婕姜德健吴建平刘学武吕玟妍陈祖辉成飞
Owner CENT SOUTH UNIV
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