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A kind of biological cellulose composite gel material and its application as wound dressing

A technology of biocellulose and wound dressings, which is applied in the preparation of wound dressing products, and in the field of biocellulose composite gel new materials, which can solve problems such as limiting cell adhesion and proliferation, and application limitations of biocellulose

Active Publication Date: 2022-06-21
HAINAN GUANGYU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the relatively dense spatial structure of biocellulose hydrogel, it is not easily absorbed by the human body, and its dense grid often limits cell adhesion and proliferation during use.
This limits the application of biocellulose in wound dressings

Method used

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  • A kind of biological cellulose composite gel material and its application as wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation Example 1 of Composite Gel Material

[0025] 1) Preparation of biocellulose hydrogel film by static fermentation method: use coconut water medium, Acetobacter xylinum, ferment and culture in shallow tray at 28°C for 7 days, and collect the biocellulose hydrogel film on the liquid surface . After cleaning and purification, it can be used for later use;

[0026] 2) Dehydrate the biocellulose hydrogel membrane to a water content of 60% by mechanical pressure, then soak it in a 0.7wt% globulin solution, ultrasonically shake it for 6 hours, take it out and wash it with water;

[0027] 3) Take 0.05M sodium chloride solution, adjust the pH value to 4 with dilute hydrochloric acid, heat it to 80°C, then immerse the biocellulose hydrogel film obtained in step 2) in it, and heat and keep it for 5 hours;

[0028] 4) Take out clean water and wash.

[0029] That is, the composite gel material of the present invention is obtained.

Embodiment 2 ： preparation example 2

[0031] 1) Preparation of biocellulose hydrogel membranes by static fermentation method: using artificially prepared medium, Acetobacter xylinum, fermented and cultured in shallow trays at 29 °C for 9 days, and collected the biocellulose hydrogel membranes on the liquid surface . After cleaning and purification, it can be used for later use;

[0032] 2) Dehydrate the biocellulose hydrogel membrane to a water content of 40% by mechanical pressure, then soak it in a 1wt% ovalbumin solution, ultrasonically shake it for 8 hours, take it out and wash it with water;

[0033] 3) Take 0.2M calcium chloride solution, adjust the pH value to 5 with dilute hydrochloric acid, heat to 70°C, and then immerse the biocellulose hydrogel film obtained in step 2) into it, and heat and maintain for 4 hours;

[0034] 4) Take out clean water and wash.

Embodiment 3

[0035] Example 3: Preparation Example 3 of Composite Gel Material

[0036] 1) Preparation of biocellulose hydrogels by shaker dynamic fermentation method: use artificially prepared medium, Acetobacter xylinum, and shaken dynamic fermentation culture at 27°C for 5 days, collect biocellulose hydrogels, wash and purify them for later use use;

[0037] 2) The collected biocellulose hydrogel was pressed into a film by mechanical pressure, and dehydrated to a water content of 70%, then immersed in a 3wt% soybean protein solution, ultrasonically vibrated for 16 hours, taken out, and washed with water;

[0038] 3) Take 0.1M sodium chloride solution, adjust the pH value to 3 with dilute hydrochloric acid, heat to 65°C, and then immerse the biocellulose hydrogel film obtained in step 2) into it, and heat and maintain for 6 hours;

[0039] 4) Take out clean water and wash.

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Abstract

The invention relates to a new biological cellulose composite gel material and its new application in preparing wound dressing products. The composite gel provided by the invention is composed of biological cellulose hydrogel and protein thixotropic gel. Biocellulose hydrogel has high water content, good water retention and sufficient mechanical strength. The protein gel is formed in the biological cellulose spatial structure, which can maintain the spatial structure of the biological cellulose hydrogel and promote cell adhesion and proliferation. It can also form a protein thixotropic gel, which can be converted from a protein gel to a protein sol by mechanical pressing before or during use to further promote cell adhesion and proliferation, and slowly release globulin that has not been converted into a gel , to further improve the antibacterial and anti-inflammatory properties of the dressing, and promote wound healing.

Description

technical field [0001] The present application relates to a new material, in particular to a new biocellulose composite gel material, and its new use in the preparation of wound dressing products. Background technique [0002] Wound dressings usually refer to wound dressings, which are used to cover wounds or other wounds to protect the wound from external mechanical, pollution and chemical stimuli, prevent secondary infection, prevent drying and loss of body fluids and heat. Traditional wound dressings are mainly dry gauze and oil gauze. However, dry gauze cannot be used in infected wounds, it does not promote wound healing, has limited ability to manage exudate, and also adheres to the wound, causing re-injury to the neo-epithelial tissue and leading to bleeding. Oil gauze contains petrolatum or triglyceride, which can play a role in non-adhesion to the wound, but it also does not promote wound healing and has limited ability to manage exudate. Modern medicine has develo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0052A61L26/0061A61L26/0066A61L2300/252A61L2300/404A61L2300/41A61L2300/412C08L89/00C08L1/02
Inventor 钟春燕钟宇光
Owner HAINAN GUANGYU BIOTECH
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