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Near-infrared long afterglow luminescent material and preparation method thereof

A technology of luminescent materials and external length, which is applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve the problems of slow charging speed, poor use effect, and poor effect, and achieve high initial near-infrared afterglow intensity, enhanced afterglow intensity, and imaging The effect of high sensitivity

Active Publication Date: 2022-07-26
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the existing near-infrared long-lasting luminescent materials can only be excited by short-wavelength ultraviolet light, which will damage biological tissues and have a shallow penetration depth in biological tissues. Previously, long-lasting luminescent probes required pre-excitation, which limited their flexibility as probes and were not conducive to their long-term in vivo bioimaging.
Although there are very few reports that some near-infrared luminescent materials can be excited by low-energy red light, the effect is very poor
The literature published by scholars such as Zhengwei Pan and Yafei Chen shows that among the near-infrared long-lasting luminescent materials that have been reported so far, the only one whose activation wavelength is within the biological transparent window is ZnGa 2 o 4 :Cr 3+ , Hanghang Liu and other scholars have published literature showing that ZnGa 2 o 4 :Cr 3+ It can be excited by 650nm deep red light, but the excitation efficiency is very low, and the charging speed is slow. When using it, it needs to be irradiated with strong near-infrared light for a long time, and the effect is very poor.
It is impossible to use high-energy light to repeatedly excite long afterglow probes in organisms, prolonging the continuous luminescence time of afterglow, which seriously limits the application of long afterglow probes

Method used

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  • Near-infrared long afterglow luminescent material and preparation method thereof
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  • Near-infrared long afterglow luminescent material and preparation method thereof

Examples

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Embodiment 1

[0029] In this example, containing Na + The compound is preferably anhydrous sodium carbonate, and the rare earth oxide containing trivalent rare earth elements is preferably gadolinium trioxide, containing Ti 4+ The compound is preferably titanium dioxide, containing Cr 3+ The compound is preferably trivalent chromium solution Cr(NO 3 ) 3 ·9H 2 O(AR). Accurately weigh the raw materials according to the stoichiometric ratio: respectively weigh seven groups of excess 30%-50% anhydrous sodium carbonate (Na 2 CO 3 ) 0.371g, titanium dioxide (TiO 2 ) 0.7986g and rare earth oxides (Gd 2 O 3 ) 0.9063g was mixed in an agate mortar to obtain a mixed powder with the same composition in seven groups. Use a pipette to pipette the trivalent chromium solution Cr(NO 3 ) 3 ·9H 2 O(AR) was added to the above seven groups of mixed powders, the trivalent chromium solution Cr(NO 3 ) 3 ·9H 2 The concentration of O(AR) was 0.01 mol / L. Then add dehydrated ethanol and grind to unifor...

Embodiment 2

[0031] In this example, containing Na + The compound is preferably anhydrous sodium carbonate, and the rare earth oxide containing trivalent rare earth elements is preferably lanthanum trioxide (La 2 O 3 ), with Ti 4+ The compound is preferably titanium dioxide, containing Cr 3+ The compound is preferably trivalent chromium solution Cr(NO 3 ) 3 ·9H 2 O(AR). Accurately weigh the raw materials according to the stoichiometric ratio: respectively weigh 30%-50% excess anhydrous sodium carbonate (Na 2 CO 3 ) 0.371g, titanium dioxide (TiO 2 ) 0.7986g and rare earth oxides (La 2 O 3 ) 0.8145g was mixed in an agate mortar to obtain a mixed powder. Pipette a volume of 10 μL of trivalent chromium solution Cr(NO 3 ) 3 ·9H 2 O (AR) was added to the above mixed powder respectively, the trivalent chromium solution Cr (NO 3 ) 3 ·9H 2 The concentration of O (AR) was 0.01 mol / L. Then add absolute ethanol and grind until uniform, put the above mixture into corundum crucible, pl...

Embodiment 3

[0033] This example contains Na + The compound is preferably anhydrous sodium carbonate, and the rare earth oxide containing trivalent rare earth elements is preferably yttrium trioxide (Y 2 O 3 ), with Ti 4+ The compound is preferably titanium dioxide, containing Cr 3+ The compound is preferably trivalent chromium solution Cr(NO 3 ) 3 ·9H 2 O(AR). Accurately weigh the raw materials according to the stoichiometric ratio: respectively weigh 30%-50% excess anhydrous sodium carbonate (Na 2 CO 3 ) 0.371g, titanium dioxide (TiO 2 ) 0.7986g and rare earth oxides (Y 2 O 3 ) 0.565g was mixed in an agate mortar to obtain a mixed powder. The rest of the reaction conditions are the same as in Example 2 above.

[0034] A near-infrared long afterglow luminescent material with perovskite structure is prepared, and its chemical composition expression is: Na 0.5 Y 0.5 Ti 1-x O 3 :xCr 3+ , where x=0.001%. In the accompanying drawings of the present invention, the chemical com...

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Abstract

The invention relates to a near-infrared long afterglow luminescent material and a preparation method thereof. The chemical composition expression of the material is Na 0.5 Ln 0.5 Ti 1‑x O 3 :xCr 3+ , where 0.001%≤x≤0.03%, and Ln selects Gd, La or Y. The content of Cr in this doping range can significantly enhance the afterglow intensity of the material, the luminescence wavelength of the material is in the range of 650-1050nm, the main peak is around 760nm, which is within the biological transparency window, and has good biological tissue penetration; The material can be effectively activated by deep red light and near-infrared light of 650-850 nm, and the reactivation of in vivo markers by external light source can be conveniently realized at any time. In addition, when the rare earth element Gd is selected, the long afterglow property can be quickly activated under the excitation of low-power low-energy light, and the material provided by the present invention has a high initial near-infrared afterglow intensity, high work efficiency, and high imaging sensitivity. At the same time, the material has good paramagnetic properties and can be used as a marker for magnetic resonance imaging to realize optical / magnetic resonance dual-function biological imaging.

Description

technical field [0001] The invention relates to the field of near-infrared luminescent materials, in particular to a near-infrared long afterglow luminescent material and a preparation method thereof. Background technique [0002] Near-infrared (NIR) long afterglow luminescent material refers to an afterglow luminescent material that can continue to emit near-infrared photons after the excitation of the external light source is stopped. Using near-infrared long afterglow luminescence for biological imaging, that is, using near-infrared light as a monitoring signal, can improve the penetration depth of optical signals in biological tissues. In addition, using the afterglow signal for biological imaging can effectively solve the influence of autofluorescence on imaging and improve the spatial resolution of imaging. However, most of the existing near-infrared long afterglow luminescent materials can only be excited by short-wavelength ultraviolet light, which can damage biolog...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/78
CPCC09K11/7701
Inventor 孟建新黄利娟
Owner JINAN UNIVERSITY
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