Graphene transistor label-free glucose sensor and preparation method thereof

A graphene and transistor technology, applied in the field of biosensors, can solve the problems of time-consuming, expensive instruments, etc., and achieve the effects of high sensitivity, low cost, and lower operating voltage

Active Publication Date: 2020-06-02
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the methods for detecting glucose concentration are mainly spectrophotometer, high performance liquid chromatography, titration and enzy

Method used

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  • Graphene transistor label-free glucose sensor and preparation method thereof
  • Graphene transistor label-free glucose sensor and preparation method thereof
  • Graphene transistor label-free glucose sensor and preparation method thereof

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preparation example Construction

[0037] The present invention also provides a preparation method for the graphene transistor sensor described in the above technical solution, comprising the following steps:

[0038] (1) Prepare gate, source and drain on the surface of the substrate, so that there is a channel between the source and drain;

[0039] (2) Graphene is tiled on the channel between the source and the drain to obtain a graphene transistor;

[0040](3) carbon dots are fixed on the grid surface of the graphene transistor obtained in the step (2), to obtain a graphene transistor sensor.

[0041] In the present invention, gate, source and drain are prepared on the substrate surface, so that a channel exists between the source and drain. In the present invention, the preparation of the gate electrode, the source electrode and the drain electrode preferably includes: sequentially vapor-depositing a chromium layer and a gold layer on the surface of the substrate by a thermal evaporation coating method.

...

Embodiment 1

[0067] Thermal evaporation coating:

[0068] Cut the electronic grade glass into 12×12mm size, ultrasonically clean it with acetone, isopropanol, and ethanol for ten minutes, dry it in an oven, paste the glass piece on a mask plate of a specific shape with high-temperature glue, and weigh an appropriate amount The chromium and gold are put into the tungsten boat to prepare the vacuum thermal evaporation coating.

[0069] When evaporating, first evaporate chromium: the thickness is 8nm.

[0070] Evaporation gold layer again: the thickness is 50nm.

[0071] The obtained electrode shape, structure and size are as follows image 3 shown. image 3 Among them, G is the gate, that is, the gate, S is the source, that is, the source, D is the drain, that is, the drain, and the 0.25mm wide channel between the source and the drain is the graphene channel after graphene is transferred.

[0072] Wet transfer of monolayer graphene:

[0073] 250 mg of methyl methacrylate (PMMA) with a mol...

Embodiment 2

[0082] Thermal evaporation coating:

[0083] Cut the electronic grade glass into 12×12mm size, ultrasonically clean it with acetone, isopropanol, and ethanol for ten minutes, dry it in an oven, paste the glass piece on a mask plate of a specific shape with high-temperature glue, and weigh an appropriate amount The chromium and gold are put into the tungsten boat to prepare the vacuum thermal evaporation coating.

[0084] When evaporating, chrome is evaporated first: the thickness is 6nm.

[0085] Evaporate a gold layer again: the thickness is 35nm.

[0086] The shape, structure and size of the obtained electrode are the same as in Example 1.

[0087] Wet transfer of monolayer graphene:

[0088] 250 mg of methyl methacrylate (PMMA) with a molecular weight of 99600 g / mol was dissolved in 5 mL of anisole, and stirred on a magnetic stirrer to obtain a clear and transparent PMMA / anisole solution with a concentration of 50 mg / mL.

[0089] Cut the single-layer copper-based graphe...

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Abstract

The invention provides a graphene transistor glucose sensor which can perform unmarked detection on glucose in liquid, and comprises a substrate, and a grid electrode, a source electrode and a drain electrode which are arranged on the substrate. A graphene channel is arranged between the source electrode and the drain electrode, and carbon dots are fixed on the surface of the grid electrode. According to the invention, the carbon dots are fixed on the surface of the grid electrode of the graphene transistor, and the carbon dots can be covalently combined with free glucose in the solution, so that the interface characteristics of the double electric layers between the transistor and the sample solution are changed through a steric effect, and the current in the graphene channel is changed;the trace glucose in the solution can be detected by detecting the current change in the channel; the operation voltage of the graphene transistor glucose sensor provided by the invention is lower than 1V, the lowest detection limit of glucose can reach 10 <-14 > M, and after the glucose concentration is changed, the current of the sensor is immediately changed, so that the sensitivity is very high.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a graphene transistor label-free glucose sensor and a preparation method thereof. Background technique [0002] With the development of nanotechnology, many chemical and biological sensors or electronic devices based on nanomaterials are widely studied, and graphene is considered as a promising material in chemical and biological sensors due to its unique physical properties. [0003] Graphene sensors are sensors that use changes in the surface potential of electrodes or channels to convert the perceived potential changes into usable output signals. Graphene sensors have many important applications, such as healthcare, environmental monitoring, and food safety inspections. [0004] Glucose plays an important role in the field of biology. It is the energy source and metabolic intermediate product of living cells, that is, the main energy supply material for organisms. The cent...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/48
CPCG01N27/3271G01N27/48
Inventor 李金华范钦王贤保
Owner HUBEI UNIV
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