High-purity tripolyglycerol monolaurate and preparation method and application thereof

A technology of tripolyglycerol and laurate, which is applied in the preparation, application and ether preparation of carboxylate, can solve the problems of difficulty in obtaining high-purity products, unsuitable food additives for purified products, and limited bacteriostatic activity, etc. The effect of rapid high-purity large-scale preparation

Active Publication Date: 2020-06-05
SOUTH CHINA INST OF COLLABORATIVE INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although column chromatography can recover high-purity products, it usually uses highly toxic reagents such as chloroform, methanol, resulting in purified products that are not suitable as food additives; in addition, its purification speed is slow and limited to laboratory preparation
However, distillation is generally difficult to obtain high-purity products, which seriously limits its antibacterial activity.

Method used

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  • High-purity tripolyglycerol monolaurate and preparation method and application thereof
  • High-purity tripolyglycerol monolaurate and preparation method and application thereof
  • High-purity tripolyglycerol monolaurate and preparation method and application thereof

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Effect test

Embodiment 1

[0050]Embodiment 1: the preparation of tripolyglycerol monolaurate

[0051] A preparation method of high-purity triglycerol monolaurate, comprising the following steps:

[0052] (1) Synthesis of polyglycerol: Add 1 kg of glycerol into a 2L three-necked flask, and add 2% solid NaOH as a catalyst in proportion to mass; protect with nitrogen, react at 250°C for 8 hours; (磷酸) :n (NaOH) =1:1.5 Add phosphoric acid to neutralize the alkaline catalyst, then add 5 times the mass of absolute ethanol for desalination, remove phosphate by vacuum filtration, and then distill under reduced pressure to remove ethanol and water to obtain polyglycerol;

[0053] (2) Purification of triglycerol: the polyglycerol product synthesized in step (1) is subjected to secondary molecular distillation and purification; wherein, the parameters of primary molecular distillation are: distillation temperature 150°C, condensation temperature 60°C, pressure 20Pa, speed of scraping film 150rpm, collect the hea...

Embodiment 2

[0056] Embodiment 2: the preparation of tripolyglycerol monolaurate

[0057] A preparation method of high-purity triglycerol monolaurate, comprising the following steps:

[0058] (1) Synthesis of polyglycerol: Add 1 kg of glycerol into a 2L three-necked flask, and add 2% solid NaOH as a catalyst in proportion to mass; protect with nitrogen, react at 260°C for 4 hours; (磷酸) :n (NaOH) =1:1.5 Add phosphoric acid to neutralize the alkaline catalyst, then add 5 times the mass of absolute ethanol for desalination, remove phosphate by vacuum filtration, and then distill under reduced pressure to remove ethanol and water to obtain polyglycerol;

[0059] (2) Purification of triglycerol: The polyglycerol product synthesized in step (1) is subjected to secondary molecular distillation and purification; wherein, the parameters of primary molecular distillation are: distillation temperature 170°C, condensation temperature 50°C, pressure 50Pa, speed of scraping film 200rpm, collect the he...

Embodiment 3

[0062] Embodiment 3: the preparation of tripolyglycerol monolaurate

[0063] A preparation method of high-purity triglycerol monolaurate, comprising the following steps:

[0064] (1) Synthesis of polyglycerol: Add 1 kg of glycerol into a 2L three-necked flask, and add 2% solid NaOH as a catalyst in proportion to the mass; protect with nitrogen, react at 280°C for 2 hours; according to n (phosphoric acid): n (NaOH) = 1: 1.5 Add phosphoric acid to neutralize the alkaline catalyst, then add 5 times the mass of absolute ethanol for desalination, remove phosphate by vacuum filtration, and then remove ethanol and water by vacuum distillation to obtain polyglycerol;

[0065] (2) Purification of triglycerol: The polyglycerol product synthesized in step (1) is subjected to secondary molecular distillation and purification; wherein, the parameters of primary molecular distillation are: distillation temperature 150°C, condensation temperature 60°C, pressure 60Pa, speed of scraping film ...

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Abstract

The invention provides high-purity tripolyglycerol monolaurate and a preparation method and application thereof, and relates to the technical field of food biology. The preparation method comprises four steps of polyglycerol synthesis, tripolyglycerol purification, tripolyglycerol laurate synthesis and tripolyglycerol monolaurate purification. According to the method provided by the invention, lipase 435 is used as a catalyst, tripolyglycerol and lauric acid are used as raw materials to synthesize tripolyglycerol monolaurate, molecular distillation and ethyl acetate / water extraction methods are combined, tripolyglycerol polyesters are firstly removed, and then tripolyglycerol is separated, so that large-scale rapid preparation of high-purity tripolyglycerol monolaurate is realized. The method provided by the invention realizes efficient, low-toxicity, rapid and high-purity large-scale preparation of the multifunctional food additive tripolyglycerol monolaurate.

Description

technical field [0001] The invention belongs to the field of food biotechnology, in particular to a high-purity triglycerol monolaurate and its preparation method and application. Background technique [0002] In order to maintain the safety of food and agricultural products and extend the shelf life, medium-chain fatty acids and their monoglycerides have been widely used to control the growth of foodborne pathogens. However, these fatty acid preservatives are usually insoluble in water, which severely limits their application in food preservation. Tripolyglycerol monofatty acid ester is a kind of polyglycerol fatty acid ester. It has excellent emulsifying properties and can be dissolved in water. It is recognized as a safe substance that can be added to food by the United States and the European Union. It has been reported that polyglycerol monoester has clear inhibitory effect on bacteria and yeast, and triglycerol monolaurate (TGML) has antibacterial activity and inhibit...

Claims

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Application Information

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IPC IPC(8): C07C41/09C07C41/42C07C43/13C07C67/08C07C67/54C07C69/33C12P7/64A61K31/23A61P31/04A61P31/10A23L33/12
CPCC12P7/6454C07C41/09C07C41/42C07C67/08C07C67/54C07C69/33A61K31/23A61P31/04A61P31/10A23L33/12A23V2002/00C07C43/135A23V2200/30A23V2250/18
Inventor 夏晚霞张嵩杨继国徐晓飞刘玮王云
Owner SOUTH CHINA INST OF COLLABORATIVE INNOVATION
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