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Medical hydrophilic coating composition as well as preparation method and application thereof

A technology of hydrophilic coatings and hydrophilic polymers, applied in polyurea/polyurethane coatings, coatings, devices for coating liquids on surfaces, etc., can solve the health hazards of operators and increase the production cost of coating liquids , Strict requirements for the use environment, etc., to achieve excellent adhesion, meet the requirements of biological modification and hydrophilicity, and the effect of simple and convenient application process

Inactive Publication Date: 2020-06-09
重庆创芯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many kinds of existing medical hydrophilic coatings. For example, Chinese patent application CN106421934A discloses a hydrophilic coating solution comprising polyvinylpyrrolidone, polypolyol, isocyanate, etc., and the solvent of the coating solution is methylene chloride Such as volatile and toxic organic solvents, short storage time, strict requirements on the use environment, inconvenient use, and serious harm to the health of operators; for another example, a Chinese patent application CN10341833A discloses a hydrophilic Hydrophilic polymers, polysaccharide polymers, hydroxypropyl-β-cyclodextrin, beet red, hydroxypropylmethylcellulose, silk fibroin, poloxamer, ε-polylysine, etc. The hydrophilic coating liquid is safe and healthy, but its composition is too complicated, which increases the production cost of the coating liquid
Therefore, when providing medical hydrophilic coatings, it is necessary to overcome technical problems such as complicated use process, harm to human health, and high cost.

Method used

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  • Medical hydrophilic coating composition as well as preparation method and application thereof
  • Medical hydrophilic coating composition as well as preparation method and application thereof
  • Medical hydrophilic coating composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of medical hydrophilic coating composition of the present invention comprises the following steps:

[0028] Raw materials are prepared according to the following percentages by weight (wt%): 0.1-2 parts (wt%) of hydrophilic polyurethane, 0.1-1 part (wt%) of hydrophilic polymer, 47-90 parts (wt%) of ethanol, the remainder The amount is water.

[0029] Take hydrophilic polyurethane and ethanol and mix according to the weight volume ratio of 0.2-4:100, heat and stir to dissolve, and obtain hydrophilic polyurethane ethanol solution for later use.

[0030] The hydrophilic polymer and water are mixed according to the weight volume ratio of 0.2-2:100, heated and stirred to dissolve, and the hydrophilic polymer aqueous solution is obtained for use.

[0031] The above-mentioned hydrophilic polyurethane ethanol solution and the above-mentioned hydrophilic polymer aqueous solution are mixed according to the ratio of 1-9:1, stirred and mixed evenly, and the medical...

Embodiment 2

[0037] The preparation of a microfluidic chip with a hydrophilic coating comprises the following steps:

[0038] Take 4 microfluidic chips, soak the 4 microfluidic chips in the medical hydrophilic coating composition solution described in the above experimental example 1-4 for 30-60s, take out after soaking and dry naturally for 5-10min, and then Bake the microfluidic chip in a constant temperature drying oven at 50-60°C for 1-2 hours to obtain a microfluidic chip with a hydrophilic coating, which is recorded as the microfluidic chip coated with a hydrophilic coating experiment. Groups 1-4.

[0039] In the present invention, a control group of microfluidic chips is additionally set, and the chip of the control group is a chip not coated with a hydrophilic coating.

Embodiment 3

[0041] Hydrophilicity testing of microfluidic chips with hydrophilic coatings. The contact angles of the surfaces of the microfluidic chip experimental groups 1-4 and the control group were tested respectively. figure 1 Shown is the microfluidic chip surface contact angle test chart of the control group. Figure 2 to Figure 5 The test diagrams of the surface contact angles of the microfluidic chip of the experimental examples 1-4 of the present invention are respectively shown.

[0042] Depend on Figure 1 to Figure 5 The shown microfluidic chip is coated with a hydrophilic coating before and after the comparison of the contact angle of the substrate surface. It can be clearly seen that the contact angle of the substrate surface can be changed from about 86 ° is reduced to about 46°, indicating that the hydrophilicity of the microfluidic chip is significantly enhanced after being coated with the hydrophilic coating composition of the present invention. Figure 6 Shown is a ...

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Abstract

The invention discloses a medical hydrophilic coating composition as well as a preparation method and application thereof. The coating composition comprises the following components: 0.1-2 wt% of hydrophilic polyurethane, 0.1-1 wt% of a hydrophilic polymer and 47-90 wt% of ethanol. The medical hydrophilic coating composition provided by the invention is simple in formula, is non-toxic, harmless, safe, healthy and easy to obtain, the cost of the coating is effectively reduced, the hydrophilicity of the surface of a base material can be effectively improved when the coating is applied to the surface of the base material, the obtained coating layer has excellent adhesion, a large number of functional groups such as amino groups can be introduced to the surface of the base material, and subsequent biological modification is facilitated.

Description

technical field [0001] The invention relates to the technical field of medical hydrophilic coatings, in particular to a medical hydrophilic coating composition for microfluidic chips, its preparation method and application. Background technique [0002] Microfluidics refers to the technology that integrates the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis processes into a micron-scale chip to automatically complete the entire analysis process. Microfluidic chip is the main platform for the realization of microfluidic technology. [0003] Microfluidic chips are divided according to their materials, including single crystal silicon wafer microfluidic chips, glass microfluidic chips, quartz microfluidic chips, and polymer microfluidic chips. Among them, the microfluidic chip made of high molecular polymer is widely used because of its simple manufacturing method, low production cost, can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D175/08C09D129/04C09D139/06C09D5/00B05D1/18B05D3/02B05D5/00B05D7/24
CPCB05D1/18B05D3/0254B05D5/00B05D7/24C09D5/00C09D129/04C09D139/06C09D175/08C08L39/06C08L75/08
Inventor 王茹霞于梦露钟越兰诗玉赵朝辉
Owner 重庆创芯生物科技有限公司
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