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A folic acid-modified molybdovanadic acid/c 3 n 4 Composite material, preparation method and application thereof

A technology of C3N4 and composite materials, which is applied in the direction of analyzing materials through chemical reactions, material analysis through observing the influence of chemical indicators, color/spectral characteristic measurement, etc., to achieve mild conditions, fast and stable color reaction sex high effect

Active Publication Date: 2022-07-15
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Subsequently, molybdenum-containing 12-silicon molybdenum acid, 12-germanium molybdenum acid, and 12-arsenomolybdenum acid were all used in the spectrophotometric detection of inorganic non-metallic elements, metal ions, drug molecules and proteins, etc. Catalytic properties are rarely reported for the detection of substances

Method used

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  • A folic acid-modified molybdovanadic acid/c <sub>3</sub> n <sub>4</sub> Composite material, preparation method and application thereof
  • A folic acid-modified molybdovanadic acid/c <sub>3</sub> n <sub>4</sub> Composite material, preparation method and application thereof
  • A folic acid-modified molybdovanadic acid/c <sub>3</sub> n <sub>4</sub> Composite material, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] According to the mass ratio of 1:6:20 (NH 4 ) 5 H 6 PMo 4 V 8 O 40 , folic acid and C 3 N 4 , will (NH 4 ) 5 H 6 PMo 4 V 8 O 40 and folic acid were dissolved in distilled water with a mass ratio of 1:30, and the C 3 N 4 Add the polyacid solution, and then add the folic acid solution dropwise at a rate of 10 drops / min. The obtained mixed solution was ultrasonically treated at a frequency of 30 kHz for 24 h, and the solid was separated by high-speed centrifugation, and washed with distilled water 3 times to ensure that there was no free polyacid and folic acid to obtain a solid (FA) 6 (NH 4 ) 5 PMo 4 V 8 O 40 / C 3 N 4 (10 wt%), the yield of the composite material is 80%.

[0061] (FA) prepared in Example 1 6 (NH 4 ) 5 PMo 4 V 8 O 40 / C 3 N 4 (10wt%) composite material is used to detect the concentration of sarcosine in the urine of patients, the method is as follows:

[0062] Take the urine of hospital patients with prostate cancer, filter a...

Embodiment 2

[0065] According to the mass ratio of 1:6:25 (NH 4 ) 5 H 6 PMo 4 V 8 O 40 , folic acid and C 3 N 4 , will (NH 4 ) 5 H 6 PMo 4 V 8 O 40 and folic acid were dissolved in distilled water with a mass ratio of 1:30, and the C 3 N 4 Add the polyacid solution, and then add the folic acid solution dropwise at a rate of 10 drops / min. The obtained mixed solution was ultrasonically treated at a frequency of 20 kHz for 6 h, and the solid was separated by high-speed centrifugation, and washed 3 times with distilled water to ensure that there was no free polyacid and folic acid to obtain a solid (FA) 6 (NH 4 ) 5 PMo 4 V 8 O 40 / C 3 N 4 (5 wt%), the yield of the composite material was 84%.

[0066] (FA) prepared in Example 2 6 (NH 4 ) 5 PMo 4 V 8 O 40 / C 3 N 4 (5wt%) composite material was used to detect the concentration of sarcosine in patient's urine as follows:

[0067] Take the urine of patients with prostate cancer in the hospital, filter and add 100μL TM...

Embodiment 3

[0069] According to the mass ratio of 1:6:17 (NH 4 ) 5 H 6 PMo 4 V 8 O 40 , folic acid and C 3 N 4 , will (NH 4 ) 5 H 6 PMo 4 V 8 O 40 and folic acid were dissolved in distilled water with a mass ratio of 1:30, and the C 3 N 4 Add the polyacid solution, and then add the folic acid solution dropwise at a rate of 10 drops / min. The obtained mixed solution was ultrasonicated for 10h under the condition of a frequency of 25kHz, and the solid was separated by high-speed centrifugation, and washed with distilled water 3 times to ensure that there was no free polyacid and folic acid to obtain a solid (FA) 6 (NH 4 ) 5 PMo 4 V8 O 40 / C 3 N 4 (15 wt%), the yield of the composite material is 80%.

[0070] (FA) prepared in Example 3 6 (NH 4 ) 5 PMo 4 V 8 O 40 / C 3 N 4 (15wt%) composite material was used to detect the concentration of sarcosine in patient's urine as follows:

[0071] Take the urine of patients with prostate cancer in the hospital, filter and ad...

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Abstract

The invention discloses a folic acid-modified molybdenum vanadium polyacid / C 3 N 4 Composite material, the general formula is (FA) 6 (NH 4 ) 5 PMo 4 V 8 O 40 / C 3 N 4 (nwt%), wherein FA is folic acid molecule, n is the loading amount of polyacid, and the values ​​are 5, 10, 15, 20, 25, 30; and the preparation method of composite material and its rapid detection of prostate cancer markers Methods. (FA) prepared by the present invention 6 (NH 4 ) 5 PMo 4 V 8 O 40 / C 3 N 4 (nwt%) The composite material has mild conditions, high sensitivity, and fast color reaction. In the presence of the color developer 3, 3-, 5, 5-tetramethylbenzidine, it can simultaneously react to H 2 O 2 and sarcosine for color detection, this method can replace the currently used horseradish peroxidase and sarcosine oxidase to complete the targeted detection of tumor cells.

Description

technical field [0001] The invention relates to the technical field of biomedicine and clinical diagnosis, and more particularly to a kind of folic acid compound based on vanadium molybdenum heteropolyacid loaded on C 3 N 4 formed on (FA) 6 (NH 4 ) 5 PMo 4 V 8 O 40 / C 3 N 4 Synthesis of (nwt%) complex substituted sarcosine oxidase / hydrogen peroxide dual mimetic and simultaneous chromogenic detection of H 2 O 2 and sarcosine technology. Background technique [0002] Prostate cancer (PCa) is a serious problem for male patients. In the initial detection, methods are often used including digital rectal examination, rectal ultrasound, prostate biopsy, computed tomography (CT) and multiple internal reflection (MIR). It is expensive, complicated to operate, and at the same time causes great psychological burden and physical damage to patients, and also leads to misjudgment or excessive treatment of the disease. It is urgent to develop an efficient, convenient and fast m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/78G01N21/33
CPCG01N21/78G01N21/33
Inventor 王晓红佀海培唐志杰王启文
Owner NORTHEAST NORMAL UNIVERSITY
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