Preparation and Application of Humic Acid with Photothermal Effect

Abstract

The invention relates to the field of photothermal agents for photothermal treatment of tumors, in particular to the preparation and application of humic acid with photothermal effects. Grind the coal into powder and add it to sodium pyrophosphate solution or alkali solution, heat and reflux at 90°C to dissolve the coal to form a reaction solution and bump it; after the reaction solution bumps, continue to heat and reflux for 2 hours; then cool the reaction solution to room temperature naturally , collect the supernatant by centrifugation, purify the supernatant through a gel chromatographic column, and dry to obtain humic acid. The humic acid prepared by the preparation method of the invention has the characteristics of low price, high photothermal conversion efficiency, stable photothermal efficiency and good biocompatibility. It can be used for the treatment of surface tumors such as skin and oral cavity, and it can also be used for the treatment of tumors in various cavity with the aid of the endoscopic system.

Description

technical field [0001] The invention relates to the field of photothermal agents for photothermal treatment of tumors, in particular to the preparation and application of humic acid with photothermal effects. Background technique [0002] As a new tumor treatment strategy, photothermal therapy uses the localization effect of laser and uses photothermal agent to convert the light energy of laser into heat energy to kill tumor cells, so as to realize the targeted elimination of tumor. Thanks to the development of laparoscopic technology, laser light sources and photothermal agents can be delivered clinically to the oral cavity, nasopharynx, esophagus, gastrointestinal tract, chest and abdomen, uterus, bladder and other human cavity under visible conditions. The system plays a role in the photothermal therapy of tumors. Compared with traditional surgical resection, chemotherapy, and radiotherapy, photothermal therapy has significant targeted minimally invasiveness, good therap...

AI Technical Summary

Problems solved by technology

Inorganic nanomaterials with high absorbance values ​​in the near-infrared region (such as gold nanomaterials, carbon nanomaterials, graphene, palladium nanosheets, etc.) have been widely studied in tumor photothermal therapy, but most of these inorganic materials have not been studied Clinical trials, facing problems such as high price and unknown potential long-term toxicity

However, organic materials such as Prussian blue and indocyanine green may not be able to meet the time required for photothermal treatment due to their small molecular weight and rapid degradation in the body.

[0004] Noble metal materials with plasmon resonance effect will also break the gold nanorods under relatively low-intensity laser irradiation, causing the plasmon resonance peak to disappear, resulting in a greatly reduced subsequent photothermal treatment effect

[0005] Organic nanomaterials, such as polyaniline, polypyrrole, and porphyrin liposome, etc., the synthesis process of nanomaterials synthesized by chemical methods is relatively complicated, and uncontrollable side reactions may be involved in the reaction process; and before clinical application, Chemically synthesized products often require detailed metabolic mechanism research and lengthy toxicity evaluation to ensure their safety

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