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Colitis hemostasis repairing emulsion containing vitamin K1

A technology for colitis and ulcerative colitis, applied in the field of colitis hemostatic repair emulsion, can solve the problems of not being able to achieve satisfactory results of enteritis repair treatment, treatment stress for livestock and poultry groups, and no anti-inflammatory effect, etc., to improve the eradication of colitis , improve physiological indicators, and promote the effect of intestinal development

Active Publication Date: 2020-06-23
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, VK 1 It is a fat-soluble vitamin, which is insoluble in water when taken orally. It is partially emulsified and absorbed by bile in the intestinal tract, and its utilization rate is very low, especially when the bile duct is obstructed and bile secretion is blocked. cause great stress
In addition, VK 1 It has no anti-inflammatory effect by itself, and single administration cannot achieve satisfactory results in the treatment of enteritis

Method used

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  • Colitis hemostasis repairing emulsion containing vitamin K1
  • Colitis hemostasis repairing emulsion containing vitamin K1
  • Colitis hemostasis repairing emulsion containing vitamin K1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: containing VK 1 Preparation of Diglyceride Emulsions

[0021] VK 1 It is a fat-soluble vitamin with low absorption and utilization rate, and VK is often used clinically 1 Administration in the form of injection solution. The present invention adopts duck oil diglyceride as VK 1 solvent, thereby increasing the VK 1 Improve the absorption and utilization rate, improve the curative effect, reduce the dosage of drugs, and shorten the repair period.

[0022] In the previous experiment, the mice after successful modeling of intestinal inflammation were designed into three groups: normal group, inflammation model group, and inflammation repair group, with 3 repetitions in each group, 5 mice in each repetition, and a total of 45 mice . The normal group and the inflammation model group were administered with normal saline, and the inflammation repair group was administered with VK 1 Distilled water solution 75μL / piece. The results showed that due to VK 1 I...

Embodiment 2

[0026] Embodiment 2: Effect of emulsion on body weight, colon length and MPO activity of mice with colitis Experimental animals and grouping: the test is divided into two stages:

[0027] The first stage: colitis model establishment. Divided into model group and control group, 4 repetitions in the control group, 28 repetitions in the model group, 5 for each repetition, a total of 160 mice; mice in the model group drank 3% dextran sodium sulfate (DSS) solution every day , for 7 consecutive days, the control group drank distilled water freely.

[0028] After modeling, 10 mice were selected from the model group and the control group, fasted for 12 hours, serum and various organs were collected, and growth indicators and blood biochemical indicators were detected to verify whether the model was successfully established.

[0029] Phase II: Duck Oil Diglycerides and VK 1 Synergistic intervention effect test on colitis mice.

[0030] A total of 140 mice successfully modeled in the...

Embodiment 3

[0042] Example 3 Effect of Duck Oil Diglyceride and VK1 on Inflammatory Factors in Colitis Mice

[0043] As shown in Table 2: the content of inflammatory cytokine IL-17 in group Ⅰ was not significantly different from that in groups Ⅳ, Ⅴ, and Ⅵ (P>0.05), but was significantly (P1 The interaction effect on IL-17 content in colitis mice was significant (P<0.05).

[0044] The content of inflammatory cytokine IL-1β in group Ⅰ was significantly (P1 The interaction effect on IL-1β content in colitis mice was significant (P<0.05).

[0045] The content of TNF-α in group Ⅰ was not significantly different from that in groups Ⅲ, Ⅳ, Ⅴ, Ⅵ, Ⅶ, and Ⅷ (P>0.05), but it was significantly (P1 The interaction effect on TNF-α content in colitis mice was significant (P<0.05).

[0046] There was no significant difference (P>0.05) in the IL-6 content of group Ⅰ compared with groups Ⅲ, Ⅳ, Ⅴ, Ⅶ, and the content of IL-6 in group Ⅱ was significantly (P1 The interaction effect on IL-6 content in colitis mi...

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Abstract

The invention provides a diglyceride emulsion containing VK1. The emulsion comprises duck oil diglyceride and VK1. The invention also provides a colitis repairing preparation prepared from the emulsion. A specific preparation method of the emulsion comprises the following steps of: dissolving duck oil diglyceride at a certain temperature, and fully mixing and stirring duck oil diglyceride and VK1according to a certain mass ratio to prepare the emulsion. The composition has the effects of improving the physiological indexes of colitis mice, reducing the MPO activity, reducing the intestinal inflammation factors IL-1[beta], IL-4, IL-6, IL-17, TNF-alpha and IL-10, promoting the colon intestinal tissue repair and the absorption of VK1 in the liver, and has a good bleeding stopping and repairing effect on ulcerative colitis. The repairing agent can generate good synergism and complementation effects when combined with antibiotics or traditional Chinese medicines, so the repairing curativeeffect is improved, and a novel and efficient health product for treating and repairing colitis is hopeful to be developed.

Description

technical field [0001] The invention belongs to the technical field of enteritis treatment preparations, in particular to a vitamin K-containing 1 The colitis hemostatic repair emulsion. Background technique [0002] Inflammatory bowel disease (Inflammation bowel disease, IBD) is a relapse-prone chronic mucosal immune-related disease, including Crohn's disease (Crohn's disease, CD) and ulcerative colitis (UlcerativeColitis, UC). UC is a Chronic inflammatory disease, its clinical symptoms include intestinal mucosal lesions and ulcers, colon narrowing, diarrhea and blood in the stool, etc. In recent years, with the increase in the proportion of raw food for human beings and the risk of food quality and safety, work pressure and Environmental pollution is serious, the incidence of IBD is rising sharply in Asia, and the incidence of IBD in developing countries is increasing rapidly, and the treatment of enteritis will face a major health challenge. [0003] UC is a complex dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/122A61K47/14A61K31/215A61P1/00A61P1/04A61P7/04
CPCA61K31/122A61K9/107A61K47/14A61K31/215A61P1/00A61P1/04A61P7/04A61K2300/00Y02A50/30
Inventor 王宝维丛红霞葛文华张名爱王茜徐慧心孔敏凡文磊
Owner QINGDAO AGRI UNIV
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