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Anti-inflammatory drug for surgical postoperative nursing and preparation method thereof

A technology of anti-inflammatory drugs and compositions, applied in the direction of anti-inflammatory agents, drug combinations, pharmaceutical formulations, etc., can solve problems such as changes in blood images, organ dysfunction, and long-term prognosis

Pending Publication Date: 2020-07-07
诸城市相州中心卫生院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Severe inflammatory reactions can cause fever, blood changes, and even multiple organ dysfunction, and the immunosuppression caused by compensatory anti-inflammatory reactions can cause infection and sepsis in the body, affecting postoperative recovery and long-term prognosis

Method used

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  • Anti-inflammatory drug for surgical postoperative nursing and preparation method thereof
  • Anti-inflammatory drug for surgical postoperative nursing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] An anti-inflammatory pharmaceutical composition for postoperative care, comprising the following raw material components in percentage by weight: 4% celecoxib, 1% tetrandrine, 15% sucrose, 10% sodium carboxymethyl starch, Talc 16%, Corn Starch 54%.

[0029] The anti-inflammatory pharmaceutical composition is a capsule, and its preparation method comprises the following steps:

[0030] 1) take each raw material component by weight percentage, for subsequent use;

[0031] 2) Mix celecoxib, tetrandrine, sodium carboxymethyl starch and corn starch evenly, pass through a 100-mesh sieve, add sucrose aqueous solution to make a soft material, and set aside;

[0032] 3) Pass the soft material through a 30-mesh sieve, granulate, and dry with blast at 50°C;

[0033] 4) Pass through a 20-mesh sieve for granulation, add talcum powder, and mix evenly;

[0034] 5) Fill the obtained granules into the capsule shell and pack.

Embodiment 2

[0036] An anti-inflammatory pharmaceutical composition for surgical postoperative care, comprising the following raw material components in percentage by weight: celecoxib 3%, tetrandrine 2%, polyvinylpyrrolidone 20%, glycyl starch sodium 6 %, micronized silica gel 8%, microcrystalline cellulose 61%.

[0037] The anti-inflammatory pharmaceutical composition is a capsule, and its preparation method comprises the following steps:

[0038] 1) take each raw material component by weight percentage, for subsequent use;

[0039] 2) Mix celecoxib, tetrandrine, sodium glycyl starch and microcrystalline cellulose evenly, pass through a 50-mesh sieve, add an aqueous solution of polyvinylpyrrolidone to make a soft material, and set aside;

[0040] 3) Pass the soft material through a 10-mesh sieve, granulate, and dry with blast at 55°C;

[0041] 4) Pass through a 40-mesh sieve for granulation, add micropowder silica gel, and mix evenly;

[0042] 5) Fill the obtained granules into the ca...

Embodiment 3

[0044] An anti-inflammatory pharmaceutical composition for post-surgical care, comprising the following raw material components in percentage by weight: celecoxib 3%, tetrandrine 2%, starch slurry 15%, cross-linked cellulose 8%, Magnesium Stearate 12%, Mannitol 60%.

[0045] The anti-inflammatory pharmaceutical composition is a capsule, and its preparation method comprises the following steps:

[0046] 1) take each raw material component by weight percentage, for subsequent use;

[0047] 2) Mix celecoxib, tetrandrine, cross-linked cellulose and mannitol evenly, pass through an 80-mesh sieve, add an aqueous solution of starch slurry to make a soft material, and set aside;

[0048] 3) Pass the soft material through a 20-mesh sieve, granulate, and blow dry at 52°C;

[0049] 4) Pass through a 30-mesh sieve for granulation, add magnesium stearate, and mix well;

[0050] 5) Fill the obtained granules into the capsule shell and pack.

[0051] Anti-inflammatory and analgesic effec...

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PUM

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Abstract

The invention relates to an anti-inflammatory drug composition for surgical postoperative nursing and a preparation method thereof. The anti-inflammatory drug composition comprises the following raw material components in percentages by weight: 1-5% of celecoxib, 0.5-4% of tetrandrine, 5-25% of a binder, 4-12% of a disintegrant, 8-16% of a lubricant and 40-80% of a diluent. The drug combination ofthe celecoxib and the tetrandrine has a significant synergistic effect on reduction of postoperative inflammatory reaction, the application dose of the celecoxib and the tetrandrine can be reduced, the production cost is reduced while gastrointestinal side effects are reduced, inflammatory pain caused by surgical postoperative trauma can be reduced and pain of a patient is alleviated.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to an anti-inflammatory pharmaceutical composition for postoperative care and a preparation method thereof. Background technique [0002] Surgery can cause local inflammatory reactions, and even systemic inflammatory response syndrome (SIRS) can occur in severe cases. Before 2016, most scholars believed that after the inflammatory storm, there was a proportional compensatory anti-inflammatory response (CARS). After the occurrence of CARS, the body showed immunosuppression, and the degree of immunosuppression was related to the peak value of the initial inflammatory factors. Because immunosuppression protects the body from an excessive inflammatory response, until research first suggested that CARS and SIRS occur almost simultaneously, postoperatively there is a "net effect" of both, revealing that postoperative recovery is a two-way A reciprocal, continuous inflammatory respons...

Claims

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Application Information

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IPC IPC(8): A61K31/415A61K31/4748A61P29/00A61K9/48
CPCA61K31/415A61K31/4748A61P29/00A61K9/4866A61K2300/00
Inventor 封长江杜怀明周慧霞
Owner 诸城市相州中心卫生院
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