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Application of lycium barbarum polysaccharide to preparation of medicaments for preventing and treating eye diseases

A technology for Lycium barbarum polysaccharide and eye diseases, which is applied in the field of medicine and achieves the effects of high safety, clear efficacy, and prevention and treatment of cataracts

Pending Publication Date: 2020-07-17
宁夏天仁枸杞生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lycium barbarum polysaccharides have many reports on regulating the body's immunity, scavenging oxygen free radicals, inhibiting tumors, delaying aging, lowering blood lipids, lowering blood sugar, and anti-fatigue, but there are fewer reports on the effects of wolfberry polysaccharides on relieving visual fatigue and preventing eye diseases

Method used

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  • Application of lycium barbarum polysaccharide to preparation of medicaments for preventing and treating eye diseases
  • Application of lycium barbarum polysaccharide to preparation of medicaments for preventing and treating eye diseases
  • Application of lycium barbarum polysaccharide to preparation of medicaments for preventing and treating eye diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the impact of LBP on human retinal pigment epithelial cells (ARPE-19);

[0023] 1. Experimental materials

[0024] Cell line: human retinal pigment epithelial cells (ARPE-19), purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences, part of which was stored in liquid nitrogen after being cultured and passaged stably for future use.

[0025] The raw material wolfberry is produced in Ningxia, and the wolfberry and wolfberry wine extract are provided by Senmiao Company.

[0026] Reagents and instruments: BPMI1640 and DMEM cell culture medium were purchased from GIBCO; fetal bovine serum and calf serum were purchased from Sijiqing; Annexin V-FITC apoptosis kit, CCK-8 kit, cell lysate, DCFH-DA reagent The kit was purchased from Abcam, and the MDA kit was purchased from Nanjing Jiancheng Institute of Bioengineering. Other chemical reagents, such as Tris-base (PH=0.5), H 2 o 2 etc. are analytically pure. The carbon dioxide incubator was purc...

Embodiment 2

[0075] Example 2: Effect of LBP on NMDA-induced retinal damage in rats

[0076] 1. Experimental materials

[0077] Experimental animals: clean grade Sprague-Dawley rats, 7-8 weeks old, weighing 120-150 g, provided by the Experimental Animal Center of Ningxia Medical University, animal qualification certificate number: SCXK (Ning) 2012-0006

[0078] Drugs and reagents: LBP was purchased from Ningxia Wofu Bairui Biological Food Co., Ltd., content ≥ 30%, batch number: 64WFBR100501; sodium pentobarbital, NMDA, sodium chloride, and paraformaldehyde were purchased from Sigma; KGI protein The extraction kit and KGI BCA protein content detection kit were purchased from Nanjing KGI Biotechnology Development Co., Ltd.; rabbit anti-rat eNOS and iNOS antibodies were purchased from Abcam; rabbit anti-rat NMDAR2A antibody and rabbit anti-β-actin antibody were purchased from From Cell Signaling Company; goat anti-rabbit secondary antibody was purchased from Beijing Zhongshan Jinqiao Biotech...

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Abstract

The invention relates to the field of medicines, and in particular to an application of lycium barbarum polysaccharide to preparation of medicaments for preventing and treating eye diseases, and aimsto provide the application of the lycium barbarum polysaccharide to preparation of medicaments for preventing and treating eye diseases, wherein the medicaments have functions of relieving visual fatigue and preventing and treating the eye diseases. The application comprises the process of mixing the lycium barbarum polysaccharide with pharmaceutically acceptable auxiliary materials or auxiliary components to prepare various forms of tablets, powders, granules, pills, paste, capsules or eye drops. The application has the beneficial effects that the medicaments or health-care products comprising the lycium barbarum polysaccharide have effects of relieving visual fatigue, preventing and treating eye diseases such as cataract, glaucoma, eye degenerative diseases and the like, has a definite medicine effect and high safety, and provides a new medicine selection for clinic.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of Lycium barbarum polysaccharide in the preparation of medicines for preventing and treating eye diseases. Background technique [0002] Lycium barbarum is the dry and mature fruit of Lycium barbarum Ningxia, a plant of the family Solanaceae. It is mainly distributed in Xinjiang, Ningxia, Qinghai and other regions of China. Lycium barbarum is not only a famous and precious Chinese medicinal material, but also one of many nutritional and health foods because of its unique nourishing effect. According to the Pharmacopoeia, wolfberry has the effects of nourishing energy, improving eyesight and nourishing liver and kidney. Lycium barbarum polysaccharide (LBP) is the main chemical component of Lycium barbarum extract, which is a water-soluble polysaccharide compound composed of six monosaccharides: glucose, arabinose, rhamnose, mannose, xylose and galactose. Lycium barbarum ...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P27/02A61P27/06A61P27/12
CPCA61K31/715A61P27/02A61P27/06A61P27/12
Inventor 于哲雄
Owner 宁夏天仁枸杞生物科技股份有限公司
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