A preparation method and application of oral microspheres loaded with mscs-derived exosomes
A technology of exosomes and sources, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, microcapsules, etc., can solve the problem of unstable therapeutic effect, large infusion dose, and the efficiency of autoimmune diseases. Low-level problems, to achieve the effect of ensuring long-term survival, convenient operation, and stable release
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Embodiment 1
[0037] An oral microsphere loaded with MSCs-derived exosomes, the preparation method of which comprises the following steps:
[0038] (1) Preparation of ALG / CST outer core solution:
[0039] Weigh sodium alginate ALG and chitosan CST respectively, add each into double-distilled water to disperse, prepare sodium alginate solution and chitosan solution, and fully dissolve them respectively; after cooling to room temperature, mix the two according to a certain ratio, and stir thoroughly Until uniform; the concentration of ALG / CST outer core solution is 1% ALG / 1% CST.
[0040] (2) Preparation of ALG / CNC core solution:
[0041] Weigh sodium alginate ALG and sodium hydroxymethylcellulose CNC-Na respectively, add each into double-distilled water to disperse, and dissolve fully respectively to prepare sodium alginate solution and sodium hydroxymethylcellulose solution; after cooling to room temperature, the two or mixed according to a certain ratio, fully stirred until uniform; the co...
Embodiment 2
[0048] An oral microsphere loaded with exosomes derived from MSCs, the preparation method of which comprises the following steps:
[0049] (1) Preparation of ALG / CST outer core solution:
[0050] Weigh sodium alginate ALG and chitosan CST respectively, add each into double-distilled water to disperse, prepare sodium alginate solution and chitosan solution, and fully dissolve them respectively; after cooling to room temperature, mix the two according to a certain ratio, and stir thoroughly until uniform; the concentration of the ALG / CST outer core solution is 1% ALG / 1% CST.
[0051] (2) Preparation of ALG / CNC core solution:
[0052] Weigh sodium alginate ALG and sodium hydroxymethylcellulose CNC-Na respectively, add each into double-distilled water to disperse, and dissolve fully respectively to prepare sodium alginate solution and sodium hydroxymethylcellulose solution; after cooling to room temperature, the two or mixed according to a certain ratio, fully stirred until unif...
Embodiment 3
[0059] An oral microsphere loaded with exosomes derived from MSCs, the preparation method of which comprises the following steps:
[0060] (1) Preparation of ALG / CST outer core solution:
[0061] Weigh sodium alginate ALG and chitosan CST respectively, add each into double-distilled water to disperse, prepare sodium alginate solution and chitosan solution, and fully dissolve them respectively; after cooling to room temperature, mix the two according to a certain ratio, and stir thoroughly until uniform; the concentration of the ALG / CST outer core solution is 1% ALG / 1% CST.
[0062] (2) Preparation of ALG / CNC core solution:
[0063] Weigh sodium alginate ALG and sodium hydroxymethylcellulose CNC-Na respectively, add each into double-distilled water to disperse, and dissolve fully respectively to prepare sodium alginate solution and sodium hydroxymethylcellulose solution; after cooling to room temperature, the two or mixed according to a certain ratio, fully stirred until unif...
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