Application of lactobacillus plantarum powder in regulating fat metabolism and intestinal flora of obese rats

A technology of Lactobacillus plantarum and intestinal flora, applied in the direction of Lactobacillus, application, metabolic diseases, etc., can solve problems such as hidden safety hazards, and achieve the effect of reducing body fat

Pending Publication Date: 2020-07-31
HEBEI NORMAL UNIV +1
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  • Abstract
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Problems solved by technology

[0003] Most of the rapid treatment of obesity now takes a certain dose of drugs, but most of the traditional western medicines or traditional Chinese medicines have certain side effects, and there are certain p

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  • Application of lactobacillus plantarum powder in regulating fat metabolism and intestinal flora of obese rats
  • Application of lactobacillus plantarum powder in regulating fat metabolism and intestinal flora of obese rats
  • Application of lactobacillus plantarum powder in regulating fat metabolism and intestinal flora of obese rats

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Embodiment Construction

[0027] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described examples are only a part of the embodiments of the present invention, rather than all of them.

[0028] 1 The effect of Lactobacillus plantarum powder on lipid metabolism in obese rats

[0029] 1.1 Experimental materials

[0030] Fifty clean-grade healthy male SD rats, weighing 130±10g, were purchased from the Experimental Animal Center of Hebei Medical University, certificate number: 1806113, animal license number: SCXK (冀)2013-1-003. All rats were reared in the same room in separate cages, with 5 in each cage, free to eat and drink, and the light cycle of day and night was 12h light and 12h dark. The ambient temperature is controlled at 23±2℃, and the humidity is 55%-65%. After the experimental animals were purchased, they were adaptively fed in ...

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Abstract

The invention provides an application of lactobacillus plantarum powder in regulating fat metabolism and intestinal flora of fat rats. The lactobacillus plantarum powder can reduce the in-vivo fat content, increased under induction of high-fat diet, of rats and reduce the body fat rate; the FFA content, increased under induction of high-fat diet, in serum of rats can be remarkably reduced; meanwhile, the TG content in the serum of obese rats can be reduced, and the HDL-C content is increased; the lipid metabolism function of the livers of the obese rats can be improved, and activation of a fatty acid synthesis pathway of the obese rats is inhibited; the condition of intestinal flora disorder of the obese rats can be improved, and the flora richness, flora diversity, flora structure and composition of the obese rats can be maintained; increase of relative abundance of firmicutes is inhibited; the relative abundance of bacteroides is improved; the relative abundance ratio of the firmicutes to the bacteroides in intestinal tracts of rats under the condition of high fat diet is reduced; and the similarity of intestinal flora of the obese rats and healthy rats is increased.

Description

Technical field [0001] The invention belongs to the field of biological food, and specifically designs the application of plant lactobacillus powder to regulate fat metabolism and intestinal flora in obese rats. Background technique [0002] Obesity is a chronic metabolic disease, which not only directly affects human health, but may also cause secondary diseases such as hypertension and diabetes. In severe cases, it will accelerate aging and death. Genetics, environment, eating habits and other factors can cause body obesity, and high-fat eating habits are the main cause of acquired obesity. Compared with the ordinary diet, the outstanding feature of the high-fat diet is the high fat content. A large intake of high-fat diet can cause the body's lipid metabolism disorder, a large accumulation of fat, and cause intestinal flora disorders. [0003] Nowadays, most of the fast treatment of obesity diseases takes a certain dose of drugs, but most traditional western medicines or tradit...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K35/747A61K9/14A61P3/04A61P1/00A61P1/16A23K10/18A23K50/50
CPCA61K49/0008A61K35/747A61K9/14A61P3/04A61P1/00A61P1/16A23K10/18A23K50/50A23V2400/169
Inventor 赵宝华刘尧尧荀一萍李璐朱宏王世杰
Owner HEBEI NORMAL UNIV
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