Application of chimonanthus salicifolius ethyl acetate parts in preparation of auxiliary anti-tumor drugs

An anti-tumor drug, the technology of ethyl acetate, applied in the field of medicine, can solve problems such as organ side effects and toxic tissues, and achieve the effects of alleviating weight loss, protecting integrity, and reducing liver toxicity

Inactive Publication Date: 2020-08-04
LISHUI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of chemotherapeutic drugs may lead to...

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  • Application of chimonanthus salicifolius ethyl acetate parts in preparation of auxiliary anti-tumor drugs
  • Application of chimonanthus salicifolius ethyl acetate parts in preparation of auxiliary anti-tumor drugs
  • Application of chimonanthus salicifolius ethyl acetate parts in preparation of auxiliary anti-tumor drugs

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Embodiment 1

[0031] Preparation of the ethyl acetate part of Chimerus osmanthus: Weigh 2000 g of the stems and leaves of Wintersweet willow that has been crushed and sieved, add 30 L of 90% ethanol aqueous solution to soak overnight, then heat and reflux with 90% ethanol aqueous solution to extract 2 times, each time 2h, suction filtration, combined filtrates to obtain the first filtrate, then reflux extraction with 16L volume fraction of 60% ethanol aqueous solution 3 times, each time 2h, suction filtration, combined filtrates to obtain the second filtrate, combined first filtrate and the second filtrate were concentrated under reduced pressure to obtain an extract; the obtained extract was dispersed in water, and then extracted with petroleum ether, chloroform, and ethyl acetate in sequence to finally obtain the ethyl acetate fraction of Waxwort. The ethyl acetate part of the willow-leaf wintersweet is dissolved in an aqueous solution with a mass fraction of 2% Tween 80, configured to a c...

Embodiment 2

[0033] Embodiment 2 pharmacological experiment

[0034] 50 ICR mice were randomly divided into 5 groups: normal control group, model group, and model + willow-leaved wintersweet group, in which the concentrations of ethyl acetate in willow-leaved wintersweet were 0.30 g / ml, 0.60 g / ml, 0.90 g / ml. After one week of adaptation to a normal diet, all the mice were administered intragastrically for 7 days, once a day, each time at 0.1ml / 10g; among them, the model+Waterweed group were given 3 concentrations of ethyl acetate parts of Willowsweet, The concentrations of the ethyl acetate parts of Waxwort willow were 0.30g / ml (low dose), 0.60g / ml (medium dose), and 0.90g / ml (high dose); the normal control group and the model group were given equal volumes of physiological brine. Modeling was established while intragastric administration, and intestinal mucositis model mice were induced by intraperitoneal injection of 25 mg / kg of 5-Fu injection on days 1 to 7.

[0035] During the exper...

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Abstract

The invention discloses application of chimonanthus salicifolius ethyl acetate parts in preparation of auxiliary anti-tumor drugs. The invention also discloses a preparation method of the chimonanthussalicifolius ethyl acetate part, which comprises the following steps: (1) preparing chimonanthus salicifolius powder, carrying out reflux extraction with an alcohol aqueous solution, filtering the extract, and carrying out vacuum concentration to obtain an extract paste; and (2) dispersing the obtained extract paste with water, sequentially extracting with petroleum ether, chloroform and ethyl acetate, and carrying out rotary concentration and drying under reduced pressure to obtain the chimonanthus salicifolius ethyl acetate part. The chimonanthus salicifolius ethyl acetate part can relievea mucositis model induced by a chemotherapeutic drug 5-Fu. The invention discloses that the chimonanthus salicifolius ethyl acetate part can be applied to auxiliary anti-cancer treatment, and meanwhile, it is prompted that a mixture of rutin, scopoletin, isofraxidin, scoparone, quercetin and kaempferol can be used for preparing auxiliary anti-tumor drugs, so that the hepatotoxicity of cancer treatment drugs is reduced, and the integrity of liver structures and functions is protected.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of the ethyl acetate part of Chimerus osmanthus in the preparation of auxiliary antitumor drugs. Background technique [0002] Chemotherapy is widely used to treat various types of cancer. However, the use of chemotherapy drugs may lead to unwanted side effects and tissue toxicity in various organs. 5-Fluorouracil (i.e. 5-FU) prevents DNA synthesis by converting intracellularly into fluorouracil deoxynucleotide, which inhibits deoxythymidylate synthase and prevents methylation of deoxyuridine into deoxythymidylate It leads to cell growth and death. In addition, 5-FU is metabolized into 5-fluorouridine monophosphate (ie, 5-FUMP), which is incorporated into RNA in the form of pseudo-metabolites to interfere with protein synthesis, so it also has effects on cells in other stages. 5-FU is mainly metabolized by the liver, with a plasma half-life of 10-20 minutes, on...

Claims

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Application Information

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IPC IPC(8): A61K36/12A61K36/185A61P35/00A61P1/16
CPCA61K36/12A61K36/185A61K2236/333A61K2236/35A61K2236/39A61P1/16A61P35/00
Inventor 温慧萍雷伟敏候景柯乐芹
Owner LISHUI UNIV
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