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Photosensitizer-loaded soluble microneedle, photosensitizer-loaded soluble microneedle array and preparation method

A microneedle array and photosensitizer technology, applied in microneedles, phototherapy, laser welding equipment, etc., can solve problems such as unreasonable drug delivery methods, improve transdermal efficiency, avoid toxic side effects, and achieve high drug utilization. Effect

Active Publication Date: 2020-08-18
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a soluble microneedle loaded with a photosensitizer, a microneedle array and a preparation method, to solve the unreasonable technology of drug delivery in photodynamic therapy problems, and at the same time solve the preparation problem of soluble microneedle array loaded with photosensitizer

Method used

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  • Photosensitizer-loaded soluble microneedle, photosensitizer-loaded soluble microneedle array and preparation method
  • Photosensitizer-loaded soluble microneedle, photosensitizer-loaded soluble microneedle array and preparation method
  • Photosensitizer-loaded soluble microneedle, photosensitizer-loaded soluble microneedle array and preparation method

Examples

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Effect test

preparation example Construction

[0041] A method for preparing a soluble microneedle array loaded with a photosensitizer, comprising the following steps:

[0042] 1) Preparation of polydimethylsiloxane (PDMS) mold plate: polydimethylsiloxane (PDMS) and curing agent are placed in a beaker, stirred evenly, then placed in an ultrasonic cleaner to remove air bubbles, and then Pour the above mixture into a disposable petri dish and lay it flat; put the petri dish into a constant temperature vacuum drying oven, vacuumize to remove the air bubbles in the mixture, and heat to solidify the polydimethylsiloxane (PDMS); After cooling, the solidified polydimethylsiloxane (PDMS) is peeled off from the culture dish to obtain a polydimethylsiloxane (PDMS) mold plate;

[0043] 2) Laser etched polydimethylsiloxane (PDMS) microneedle negative mold: use integrated optical fiber CO 2 The laser marking machine sets the parameters to etch the polydimethylsiloxane (PDMS) mold plate, and removes the excess material to obtain the po...

Embodiment 1

[0061] Example 1: Preparation of soluble hyaluronic acid microneedle array loaded with 5-ALA

[0062] 1. Preparation of polydimethylsiloxane (PDMS) mold plate: polydimethylsiloxane (polydimethylsiloxane (PDMS)) and curing agent are placed in a beaker at a mass ratio of 10:1 , stirred for about 5 minutes, and then placed in an ultrasonic cleaner for about 10 minutes to remove air bubbles, and then pour the above mixture into a disposable petri dish so that the thickness is about 3-4mm. Put the petri dish into a constant temperature vacuum drying oven, and evacuate to a vacuum degree of -0.08MPa to eliminate air bubbles in the mixture. Heat at 80°C for 2 hours to solidify the polydimethylsiloxane (PDMS); after cooling, peel off the solidified polydimethylsiloxane (PDMS) to obtain a polydimethylsiloxane (PDMS) mold plate .

[0063] 2. Laser etching polydimethylsiloxane (PDMS) microneedle negative mold: use an integrated optical fiber CO2 laser marking machine to set parameters ...

Embodiment 2

[0066] Examples 2–6: Dissolvable microneedles loaded with photosensitizers with different parameters

[0067] In addition, according to the method of Example 1, by adjusting the structure of the negative mold of the polydimethylsiloxane (PDMS) microneedle and the concentration of the photosensitizer solution, microneedles with various parameters as shown in Table 1 were obtained.

[0068] Table 1 lists the soluble microneedles loaded with photosensitizers with different lengths, bottom diameters, distances between adjacent needle tips, photosensitizer types, and photosensitizer content prepared by the method of Example 1 of the present invention:

[0069]

[0070]

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Abstract

The invention discloses a soluble microneedle loaded with a photosensitizer. The microneedle comprises an integrally formed base, a soluble polymer needle body positioned on the base and a needle tiploaded with the photosensitizer, the invention discloses a preparation method of a photosensitizer-loaded soluble microneedle array. The preparation method comprises the following steps: 1) preparinga polydimethylsiloxane (PDMS) mold plate; 2) carrying out laser etching on a polydimethylsiloxane (PDMS) micro-needle female die; 3) preparing a mixed solution containing a photosensitizer and a soluble polymer; (4) treating the female die obtained in the step (2) with oxygen plasma, coating the surface of the female die with the mixed solution obtained in the step (3), enabling the medicine to enter the tip end of the die in a vacuum environment, and recycling the redundant medicine; adding a soluble polymer solution to the mold, and filling the mold with the soluble polymer in vacuum; afterstanding, drying is performed, and then the polydimethylsiloxane (PDMS) microneedle array female mold is peeled off. According to the invention, the technical problem of unreasonable administration mode in photodynamic therapy can be solved, and the preparation problem of the photosensitizer-loaded soluble microneedle array is also solved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to a soluble microneedle loaded with a photosensitizer, a microneedle array and a preparation method. Background technique [0002] Photodynamic therapy is a series of photochemical reactions between endogenous or exogenous photosensitizers and oxygen in target cells under the action of light waves of specific wavelengths to generate singlet oxygen, oxygen ions, peroxides, and oxygen-containing free cells. A therapeutic method that selectively destroys target tissues by inducing cell death based on reactive oxygen species. At present, photosensitizers are mostly administered externally (such as 5-ALA) or intravenously (such as hemoporfin) in photodynamic therapy. Photosensitizers are often applied externally in the form of solutions, ointments, gels, etc. However, due to the barrier effect of the skin stratum corneum, regardless of the above-mentioned dosage form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61N5/06B29D7/00B23K26/362B23K26/402
CPCA61M37/0015A61N5/062B29D7/00B23K26/362B23K26/402A61M2037/0023A61M2037/0053
Inventor 陶娟朱今巾朱锦涛李钰策张连斌杜虹瑶
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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