Rosuvastatin calcium tablet and preparation process thereof
A technology of rosuvastatin calcium and its preparation process, which is applied in the field of rosuvastatin calcium tablets and its preparation process, can solve the problems of difficult control of product impurities, impact on product quality, high production cost, etc., so as to facilitate popularization and reduce production cost , The effect of improving productivity
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Embodiment 1
[0017] Embodiment one: a kind of rosuvastatin calcium tablet, comprise following raw material: [4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methyl Sulfonyl)amino]]-5-pyrimidinyl]methyltriphenylphosphine bromide, (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4 - cyclopentyl acetate, potassium carbonate, dimethyl sulfoxide, toluene, acetonitrile, ethyl acetate, methanol, isopropanol, sodium hydroxide, sodium chloride and calcium chloride.
[0018] Another technical problem to be solved by the present invention is to provide a preparation process of rosuvastatin calcium tablets, comprising the following steps:
[0019] 1) Add 67.8g (0.1mol) [4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methylsulfonyl) to the first reaction flask )amino]]-5-pyrimidinyl]methyltriphenylphosphine bromide, 27.0g (0.1mol)(4R-cis)-6-formyl-2,2-dimethyl-1,3-diox Hexyl-4-cyclopentyl acetate, 300mL dimethyl sulfoxide, stirred and dissolved at room temperature; and heated to 25-45 degrees Celsiu...
Embodiment 2
[0023] Embodiment two: a kind of rosuvastatin calcium tablet, comprise following raw material: [4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methyl Sulfonyl)amino]]-5-pyrimidinyl]methyltriphenylphosphine bromide, (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4 - cyclopentyl acetate, potassium carbonate, dimethyl sulfoxide, toluene, acetonitrile, ethyl acetate, methanol, isopropanol, sodium hydroxide, sodium chloride and calcium chloride.
[0024] Another technical problem to be solved by the present invention is to provide a preparation process of rosuvastatin calcium tablets, comprising the following steps:
[0025]1) Add 67.8g (0.1mol) [4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methylsulfonyl) to the first reaction flask )amino]]-5-pyrimidinyl]methyltriphenylphosphine bromide, 27.0g (0.1mol)(4R-cis)-6-formyl-2,2-dimethyl-1,3-diox Hexyl-4-cyclopentyl acetate, 300mL dimethyl sulfoxide, stirred and dissolved at room temperature; and heated to 45-75 degrees Celsius...
Embodiment 3
[0029] Embodiment three: a kind of rosuvastatin calcium tablet, comprise following raw material: [4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methyl Sulfonyl)amino]]-5-pyrimidinyl]methyltriphenylphosphine bromide, (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4 - cyclopentyl acetate, potassium carbonate, dimethyl sulfoxide, toluene, acetonitrile, ethyl acetate, methanol, isopropanol, sodium hydroxide, sodium chloride and calcium chloride.
[0030] Another technical problem to be solved by the present invention is to provide a preparation process of rosuvastatin calcium tablets, comprising the following steps:
[0031] 1) Add 67.8g (0.1mol) [4-[4-fluorophenyl-6-(1-methylethyl)-2-[N-methyl-(N-methylsulfonyl) to the first reaction flask )amino]]-5-pyrimidinyl]methyltriphenylphosphine bromide, 27.0g (0.1mol)(4R-cis)-6-formyl-2,2-dimethyl-1,3-diox Hexyl-4-cyclopentyl acetate, 300mL dimethyl sulfoxide, stirred and dissolved at room temperature; and heated to 75-120 degrees Cel...
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