Tablet containing lipoic acid and preparation method thereof

A technology of lipoic acid and tablets, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, and pill delivery, etc. Smooth, rapid dissolution, rapid disintegration effect

Inactive Publication Date: 2020-08-21
NANJING HEALTHNICE MEDICAL TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is based on the prior art, to provide a kind of active component lipoic acid content is high, dissolution is rapid, the surface of tablet core is smooth, no stain, no sticking sign, high bioavailability, disintegration speed Fast tablets containing lipoic acid solve the problem of low melting point of lipoic acid and easy sticking of tablets

Method used

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  • Tablet containing lipoic acid and preparation method thereof
  • Tablet containing lipoic acid and preparation method thereof
  • Tablet containing lipoic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Formula and its weight percentage (1000 tablets dosage)

[0055]

[0056] (2) Preparation method

[0057] (1) Pretreatment: After passing the active components lipoic acid, microcrystalline cellulose, lactose and hypromellose E15 through a 60-mesh sieve, mix them in a high-speed wet mixer for 20 minutes;

[0058] (2) Ethanol solution for preparing a release agent: dissolving simethicone in ethanol to make an ethanol solution with a mass concentration of 1% simethicone;

[0059] (3) Granulation and tablet coating: After mixing the pretreated active components lipoic acid, microcrystalline cellulose, lactose and hypromellose E15 evenly, add an ethanol solution with a mass concentration of 1% simethicone 200g of soft material, granulated after passing through a 20-mesh sieve, put the obtained wet granules into a fluidized bed for drying, set the inlet air temperature at 40°C, dry until the drying weight loss of the granules is less than 4%, pass the dried granules ...

Embodiment 2

[0061] (1) Formula and its weight percentage (1000 tablets dosage)

[0062]

[0063]

[0064] (2) Preparation method

[0065] (1) Pretreatment: After passing the active components lipoic acid, microcrystalline cellulose, lactose and hypromellose E15 through a 60-mesh sieve, mix them in a high-speed wet mixer for 20 minutes;

[0066] (2) Ethanol solution for preparing a release agent: dissolving simethicone in ethanol to make an ethanol solution with a mass concentration of 2% simethicone;

[0067] (3) Granulation and tablet coating: After mixing the pretreated active components lipoic acid, microcrystalline cellulose, lactose and hypromellose E15 evenly, add an ethanol solution with a mass concentration of 2% simethicone 200g of soft material, granulated after passing through a 20-mesh sieve, put the obtained wet granules into a fluidized bed for drying, set the inlet air temperature at 40°C, dry until the drying weight loss of the granules is less than 4%, pass the dri...

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Abstract

The invention discloses a tablet containing lipoic acid and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The tablet or a tablet core thereof comprises the following components: active component lipoic acid, a filler, an adhesive, a release agent, a disintegrating agent, a flow aid and a lubricant. The preparation method comprises steps: uniformlymixing the active component, the filler, and the adhesive, adding an ethanol solution of the release agent to prepare a soft material, granulating, drying the obtained wet granules, mixing the driedgranules with the disintegrating agent, the flow aid and the lubricant, and tabletting. The tablet containing lipoic acid prepared by the method provided by the invention has the advantages of high content (not lower than 70%) of active component lipoic acid, rapid dissolution, smooth tablet core surface, no color spot, no sticking sign, high bioavailability and rapid disintegration speed, and solves the problems of low melting point of lipoic acid and easy sticking in tabletting.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a tablet containing lipoic acid and a preparation method thereof. Background technique [0002] Thioctic Acid, chemical name (±)-5-[3-(1,2-dithiolane)]-pentanoic acid, is a light yellow crystal with a strong pungent pungent odor. Lipoic acid is a coenzyme that exists in mitochondria, similar to vitamins, and can eliminate free radicals that accelerate aging and cause disease. Lipoic acid enters the cells after being absorbed by the intestinal tract in the body. It has both fat-soluble and water-soluble properties, so it can pass through the whole body unimpeded, reach any cell site, and provide comprehensive efficacy for the human body. It is a fat-soluble and water-soluble universal antibiotic. Oxidant, absorbed quickly in the body, has certain application value in stabilizing blood sugar level, strengthening liver function, improving fatigue, de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K47/34A61K31/385A61P3/10A61P25/02
CPCA61K9/2036A61K9/2095A61K9/2806A61K31/385A61P3/10A61P25/02
Inventor 陈长德邹巧根辛妮王华娟
Owner NANJING HEALTHNICE MEDICAL TECH
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