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Transdermal patch for promoting discharge of mercury from skin and preparation method of transdermal patch

A transdermal patch and absorption enhancer technology, applied in the field of external patches, can solve the problems of mercury accumulation in the skin, achieve long moisturizing period, reduce mercury content, and promote the effect of excretion

Inactive Publication Date: 2020-08-25
河南希百康健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on how to solve the problem of skin mercury accumulation caused by excessive mercury in cosmetics

Method used

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  • Transdermal patch for promoting discharge of mercury from skin and preparation method of transdermal patch
  • Transdermal patch for promoting discharge of mercury from skin and preparation method of transdermal patch
  • Transdermal patch for promoting discharge of mercury from skin and preparation method of transdermal patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A transdermal patch for promoting the excretion of mercury from the skin, comprising a patch substrate and a mercury-expelling composition attached to the patch substrate, the mercury-expelling composition is made of the following raw materials: L-selenium- Methylselenocysteine ​​6.5 mg, hyaluronic acid 91 g, glycerin 195 g, inositol 32.5 g, erythritol 6.5 g, grape seed extract 4 g, ethylbisiminomethylguaiacol Manganese chloride 0.4 g, xanthan gum 25 g, laurocaprazine 5 g, menthol 12.5 g, propylene glycol 32.5 g, water 4595.6 g.

[0038] In the above-mentioned mercury removal composition, the content of L-selenium-methylselenocysteine ​​is 0.00013%; the content of the moisturizing agent (325g in total) is 6.5%, which consists of hyaluronic acid, glycerin, inositol, erythritol It is mixed according to the mass ratio of 14:30:5:1; the content of antioxidant (4.4 g in total) is 0.088%, which is composed of grape seed extract, ethylbisiminomethylguaiacol manganese chloride ...

Embodiment 2

[0047] A transdermal patch for promoting the excretion of mercury from the skin, comprising a patch substrate and a mercury-expelling composition attached to the patch substrate, the mercury-expelling composition is made of the following raw materials: L-selenium- Methylselenocysteine ​​19.5 mg, hyaluronic acid 55 g, glycerin 192.5 g, inositol 22 g, erythritol 5.5 g, grape seed extract 2.5 g, manganese ethylbisiminomethylguaiacol Chloride 0.5 g, xanthan gum 25 g, lauroazepine 10 g, menthol 20 g, propylene glycol 70 g, water 4597.0 g.

[0048] In the above mercury removal composition, the content of L-selenium-methylselenocysteine ​​is 0.00039%; the content of the moisturizing agent (275g in total) is 5.5%, which consists of hyaluronic acid, glycerin, inositol, erythritol It is mixed according to the mass ratio of 10:35:4:1; the content of antioxidant (3 g in total) is 0.06%, which is composed of grape seed extract, ethylbisiminomethylguaiacol manganese chloride according to T...

Embodiment 3

[0050] A transdermal patch for promoting the excretion of mercury from the skin, comprising a patch substrate and a mercury-expelling composition attached to the patch substrate, the mercury-expelling composition is made of the following raw materials: L-selenium- Methylselenocysteine ​​6.5 mg, hyaluronic acid 55 g, glycerin 192.5 g, inositol 22 g, erythritol 5.5 g, grape seed extract 2.5 g, ethylbisiminomethylguaiacol Manganese chloride 0.5 g, xanthan gum 25 g, laurocapzone 10 g, menthol 20 g, propylene glycol 70 g, water 4597.0 g.

[0051] In the above mercury removal composition, the content of L-selenium-methylselenocysteine ​​is 0.00013%; the content of moisturizing agent (275g in total) is 5.5%, which is composed of hyaluronic acid, glycerin, inositol, erythritol It is mixed according to the mass ratio of 10:35:4:1; the content of antioxidant (3 g in total) is 0.06%, which is composed of grape seed extract, ethylbisiminomethylguaiacol manganese chloride according to The...

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Abstract

The invention discloses a transdermal patch for promoting discharge of mercury from skin. The patch comprises a patch base material and a mercury discharging composition attached to the patch base material, wherein the mercury discharging composition is prepared from the following raw materials in percentage by mass: 0.00003 to 0.001 percent of L-selenium-methyl selenocysteine, 0.2 to 10 percent of a humectant, 0.05 to 0.1 percent of an antioxidant, 0.1 to 0.5 percent of a thickening agent, 0.3 to 2.0 percent of a transdermal absorption enhancer and the balance of water. The invention also discloses a preparation method of the transdermal patch. The preparation process is environmentally friendly and safe, and the prepared transdermal patch for promoting discharge of mercury from skin is stable in property, is free of toxic and side effects, is free of obvious irritation to skins, has a good active ingredient transdermal absorption effect, can effectively promote discharge of mercury from skin and has far-reaching practical significance and application values.

Description

technical field [0001] The invention belongs to the technical field of external patches, and in particular relates to a transdermal patch for promoting the discharge of mercury from the skin and a preparation method thereof. Background technique [0002] Mercury can effectively inhibit the formation of melanin and has a certain whitening effect on the skin, so it is often added to cosmetics to remove freckles and whiten the skin. The higher the mercury content in cosmetics, the more pronounced the whitening effect. Because mercury can cause serious damage to the human body, the national hygiene standard for cosmetics stipulates that the mercury content in cosmetics should not exceed 1 mg / kg. Excessive levels of mercury. [0003] There are frequent reports about serious harm to consumers caused by excessive mercury content in cosmetics. Studies have shown that the skin is very easy to absorb mercury in skin care products or cosmetics. Mercury enters the skin mainly through...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/02A61K8/34A61K8/44A61K8/41A61K8/73A61K8/86A61Q19/00A61K31/198A61K9/70A61K47/46A61K47/36A61K47/10A61K47/34A61K47/18A61P39/02
CPCA61K8/9789A61K8/9794A61K8/735A61K8/345A61K8/86A61K8/44A61K8/415A61K8/0208A61Q19/00A61K31/198A61K9/7023A61K47/46A61K47/36A61K47/10A61K47/34A61K47/18A61P39/02
Inventor 张继业李清清司佩茹杨显伟王梦涵王阳李霁宇卢军亮莫菲马佳张沛沛
Owner 河南希百康健康产业有限公司
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