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Crystallization and purification method of vitamin E succinate

A technology of succinate ester and purification method, applied in organic chemistry methods, organic chemistry and other directions, can solve the problems of lack of clear data support for synthesis time, uncontrollable reaction cost, and high energy consumption of chemical synthesis, so as to save repeated washing and removal. The effect of the complex process and method is simple and easy to implement and the yield is high.

Inactive Publication Date: 2020-08-25
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problems of chemical synthesis are high energy consumption and low yield
In contrast, enzymatic synthesis is environmentally friendly, green and pollution-free, but due to the generally high market price of selected lipases, the reaction cost cannot be controlled, and the synthesis time is not supported by clear data

Method used

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  • Crystallization and purification method of vitamin E succinate
  • Crystallization and purification method of vitamin E succinate
  • Crystallization and purification method of vitamin E succinate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1) Dissolve 37.65g of vitamin E succinate crystals in 185.07g of n-hexane solution at 35°C to prepare a saturated solution, and put it into a cooling crystallizer.

[0023] 2) Add 1.51 g of vitamin E succinate solid into the cooling crystallizer, and continue stirring at a constant temperature of 35° C. at a speed of 120 rpm for 1 hour.

[0024] 3) Turn on the cooling and crystallization: turn on the program temperature controller, carry out uniform cooling at a cooling rate of 10°C / h, cool down to the final temperature of 0°C, and then stand at constant temperature for 1h.

[0025] 4) Drain the crystal slurry in the cooling crystallizer, filter the crystal slurry at 0° C., and then dry it in an oven at 70° C. to obtain a vitamin E succinate crystal product.

Embodiment 2

[0027] 1) Dissolve 34.12g of vitamin E succinate crystals in 100g of n-hexane solution at 35°C to prepare a saturated solution, and put it into a cooling crystallizer.

[0028] 2) After the saturated solution in the cooling crystallizer was cooled to 30°C, 1.51 g of vitamin E succinate solid was added, and stirring was continued at a constant temperature of 30°C at a speed of 120 rpm for 1 hour.

[0029] 3) Turn on the cooling and crystallization: turn on the program temperature controller, and carry out uniform cooling at a cooling rate of 8°C / h. After cooling down to the final temperature of 0°C, let it stand at constant temperature for 1h.

[0030] 4) Drain the crystal slurry in the cooling crystallizer, filter the crystal slurry at 0° C., and then dry it in an oven at 70° C. to obtain a vitamin E succinate crystal product.

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Abstract

The invention provides a cooling crystallization and purification method of vitamin E succinate. The method comprises the following steps: adding a certain volume of saturated vitamin E succinate solution into a cooling crystallizer, and adding a certain amount of vitamin E succinate solid; performing stirring and reacting at a constant temperature for a period of time, performing cooling and crystallizing at a certain cooling rate, and performing standing for a period of time after crystallization reaction; and discharging crystal mush generated in a crystallizer, and filtering and drying thecrystal mush to obtain a product. The cooling crystallization and purification method of the vitamin E succinate provided by the invention is simple and feasible, high in yield, and good in purification effect; compared with a traditional purification process, the method has the advantages that production of raw material reagents and repeated washing and impurity removal processes are omitted, the process route is shortened, raw material consumption and labor intensity are reduced, the recovery rate of vitamin E succinate and n-hexane is increased, and the production cost is remarkably reduced.

Description

Technical field: [0001] The invention relates to the field of purification and preparation of vitamin E succinate, in particular to a cooling crystallization method of vitamin E succinate. Background technique: [0002] Vitamin E succinate is also known as tocopherol succinate, the English name is: vitamin E succinate, its molecular formula: C 33 h 54 o 5 . Its shape is usually white powder. Vitamin E succinate is insoluble in water but easily soluble in ether, acetone and n-hexane. Vitamin E succinate is odorless, non-toxic, non-irritating, and has good biocompatibility. Vitamin E is one of the essential nutrients for the human body. Vitamin E succinate can be used to synthesize drugs. The vitamin E used in a large number of tablets and capsule nutritional supplements is vitamin E succinate, and vitamin E succinate The inhibitory effect on the growth of human cultured tumor cells is very obvious. Vitamin E succinate can also be used in the food field to make health c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/72
CPCC07D311/72C07B2200/13
Inventor 王彦飞乔占博许史杰朱亮杨立斌赵晓昱赵文立韩梅
Owner TIANJIN UNIV OF SCI & TECH