Urinary catheter and its preparation method

A technology for urinary catheters and tubes, applied in catheters, pharmaceutical formulations, coatings, etc., can solve problems such as damage and beneficial cell damage, and achieve the effects of convenient and simple operation, reducing the risk of bacterial infection, and inhibiting accumulation

Active Publication Date: 2022-03-15
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method of using ultraviolet light to sterilize bacteria is likely to cause unknown damage to the beneficial cells on the surface of the urethra, resulting in greater damage

Method used

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  • Urinary catheter and its preparation method
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  • Urinary catheter and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0089] Preparation method of urinary catheter

[0090] The present invention also provides a preparation method of a urinary catheter, comprising:

[0091] (i) forming the coating composition on the surface of the catheter body and curing it under light;

[0092] (ii) The heparin and chitosan are alternately self-assembled on the outer surface of the coating to form a heparin and chitosan bilayer, and the alternate self-assembly is repeated n times to form n layers of heparin and chitosan bimolecules layer, where n≥1.

[0093] Wherein, the coating composition is formed on the surface of the urinary catheter body by one or more methods of brushing, dipping, spraying, pouring and scraping.

[0094] Wherein, the light source used during illumination includes any one of UV light source, visible light source, and infrared light source; preferably, the light source is a UV light source and a visible light source; more preferably a UV light source. Preferably, the UV light inten...

Embodiment 1

[0100] Step 1: Synthesis of water-soluble photosensitive monomer

[0101] Weigh 22.4g (100mmol) 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 10.6g (105mmol) triethylamine and dissolve in 100mL dichloromethane and place in a 250mL flask and placed in an ice-water bath to fully dissolve. 9.1 mL of bromoacetyl bromide (21.1 g, 105 mmol) in dichloromethane was slowly added dropwise to the flask, and the dropwise addition was completed within 1 h. After reacting for 0.5 h under ice-bath conditions, the reaction was continued for 10 h at room temperature. After the reaction was completed, cool to room temperature and dissolve the crude product in dichloromethane, wash twice with saturated brine, hydrochloric acid (1M) and saturated sodium bicarbonate successively, dry over anhydrous magnesium sulfate, filter and spin dry the solvent, wash with acetic acid Ethyl ester and n-hexane were used as eluents, and after purification by column chromatography, 28.8g of 2-hydroxyl-...

Embodiment 2

[0126] The number of layers of the self-assembled bilayers of the five kinds of heparin and chitosan in the step of Example 1 was changed, and the other steps were the same as in Example 1. The lubricating properties of the samples were evaluated, and the results are shown in Table 3.

[0127] Table 3 Lubrication performance of urinary catheters with different layers of self-assembled layers

[0128]

[0129] It can be seen that the number of self-assembled bilayers of heparin and chitosan on the surface of the catheter does not have much influence on the lubricating properties of the catheter surface, and the catheter dipped in a lubricating coating can still maintain good performance. lubricating performance.

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Abstract

The invention relates to a urinary catheter and a preparation method thereof. The urinary catheter of the invention comprises: a tube body, a coating formed on the surface of the tube body, and heparin and heparin that are self-assembled layer by layer on the outer surface of the coating Chitosan, the coating is formed from a coating composition comprising at least one photocurable polymer. The urinary catheter of the present invention can prevent the catheter from damaging the inner surface of the urethra. At the same time, it can effectively inhibit the accumulation of crystals and kill the bacteria adhering to the surface of the catheter and the wound of the urethra, reducing the risk of bacterial infection.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to the field of urinary catheters with modified surfaces. Background technique [0002] The indwelling catheter method is a method of retaining the catheter in the bladder to drain urine after catheterization. It is widely used in severe patients after anesthesia or surgery, and is a commonly used invasive nursing operation in clinical practice. Catheters used in indwelling catheterization require higher performance than catheters for short-term use. The main reason is that indwelling catheters are prone to cause various complications in the body, such as catheter-associated urinary tract infection, bladder function damage, and crystal formation on the surface of catheters. [0003] The most typical problem of indwelling catheters is urinary tract infection. The insertion of catheters often causes damage to the urethral mucosa, destroys the natural barrier of the urethral mucosa, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/12A61L29/08A61L29/14A61L29/16
CPCA61L29/085A61L29/14A61L29/16A61L2400/10A61L2420/02A61L2420/08A61L2420/06C08L5/10C08L5/08C08L33/14
Inventor 李业雷杰华
Owner JIANGSU BIOSURF BIOTECH CO LTD
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