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Antibacterial medical hemostatic sponge and preparation method thereof

A hemostatic sponge and sponge technology, applied in the fields of medical formulation, application, medical science, etc., can solve the problems of prolonged wound healing time, and achieve the effect of avoiding infection and good antibacterial persistence

Inactive Publication Date: 2020-09-04
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these inventions ignore a key problem, wound infection in the process of hemostasis will lead to many sequelae, such as amputation, prolonged healing time of abscess-shaped wounds, etc.

Method used

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  • Antibacterial medical hemostatic sponge and preparation method thereof
  • Antibacterial medical hemostatic sponge and preparation method thereof

Examples

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Effect test

preparation example Construction

[0024] The application also provides a preparation method of the antibacterial medical hemostatic sponge, comprising the following steps:

[0025] A) the antibacterial agent is dissolved and mixed with halloysite, and the resulting mixed solution is evacuated to obtain halloysite loaded with antibacterial agent;

[0026] B) dissolving the biomacromolecule in water, mixing it with the halloysite loaded with the antibacterial agent, and freeze-drying to obtain an antibacterial medical hemostatic sponge.

[0027] In the process of preparing the antibacterial medical hemostatic sponge, the applicant first dissolves the antibacterial agent to make it saturated, then mixes it with halloysite, and vacuumizes the resulting mixed solution to obtain the antibacterial agent-loaded angstrom Rockstone; the antibacterial agent is in a saturated state and vacuumized with the halloysite to ensure that the hollow tube structure of the halloysite can load the antibacterial agent through capilla...

Embodiment 1

[0033] The preparation method of efficient hemostasis and long-acting antibacterial hemostatic porous sponge is as follows:

[0034] Dissolve ciprofloxacin hydrochloride in ultra-pure water to form a saturated solution; add ground halloysite with a mass ratio of 1:2 to ciprofloxacin hydrochloride, stir for 1 hour, and ultrasonicate for 15 minutes at room temperature. Improve the dispersibility of halloysite in aqueous solution; vacuumize by cyclic vacuum method, each vacuum time is 30 minutes, cycle 3 times; centrifuge at 10,000rpm for 10 minutes, wash with ultrapure water for 3 times, dry at 60°C for 5 hours, and get the load Halloysite with ciprofloxacin hydrochloride;

[0035]Sodium alginate was dissolved in ultrapure water to prepare a sodium alginate solution with a mass percentage of 2%, and drug-loaded halloysite with a mass ratio of 1:2 to sodium alginate was added to the sodium alginate solution and stirred for 4 hours. The drug-loaded halloysite is mixed evenly in t...

Embodiment 2

[0038] The preparation method of efficient hemostasis and long-acting antibacterial hemostatic porous sponge is as follows:

[0039] Dissolve gentamicin in ultrapure water to form a saturated solution; add ground halloysite with a mass ratio of 1:2 to gentamycin, stir for 1 hour, and ultrasonicate for 15 minutes at room temperature to increase the angstrom. Dispersibility of rockite in aqueous solution; Vacuumize by cyclic vacuum method, each vacuum time is 30 minutes, cycle 3 times; centrifuge at 10,000rpm for 10 minutes, wash with ultrapure water for 3 times, dry at 60°C for 5 hours, and get the loaded Qing halloysite of damycin;

[0040] Dissolve sodium alginate and dextran in ultrapure water to prepare a sodium alginate and dextran solution with a mass percentage of 2%. Add the sodium alginate solution to the alginate and stir for 4 hours, so that the drug-loaded halloysite is mixed evenly in the sodium alginate; pour the mixed sodium alginate and drug-loaded halloysite m...

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Abstract

The invention provides an antibacterial medical hemostatic sponge. The antibacterial medical hemostatic sponge is prepared from a biological macromolecule, halloysite and an antibacterial agent, wherein the biological macromolecule is used as a porous sponge skeleton, and the halloysite is loaded with the antibacterial agent. The application also provides a preparation method of the antibacterialmedical hemostatic sponge. The long-acting antibacterial hemostatic material provided by the invention can realize efficient hemostasis, and has effective hemostasis effects for a liver hemorrhage model. The antibacterial hemostatic sponge provided by the invention has good long-term antibacterial properties. In addition, the preparation method is simple and easy to implement, has no pollution tothe environment, and easily realizes mass production.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials and long-acting antibacterial technology, in particular to an antibacterial medical hemostatic sponge and a preparation method thereof. Background technique [0002] Excessive blood loss is a leading cause of casualties in hospital, emergency and battlefield settings. For example, uncontrollable hemorrhage on the battlefield will cause the mortality rate to reach about 50%. At the same time, heavy hemorrhage in surgery and first aid is also a problem often encountered by doctors. Therefore, research on hemostatic materials has attracted much attention. Usually, hemostasis is achieved through a series of coagulation cascades, including thrombus formation by activated platelets, followed by activation of multiple coagulation factors sequentially through intrinsic and / or extrinsic enzymatic pathways, thereby further strengthening the thrombus strength of platelets. At present, common hem...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L24/08A61L24/10A61L24/00C08J9/28C08J9/40C08L5/04C08L89/00C08L5/08
CPCA61L24/0015A61L24/0036A61L24/0089A61L2300/406A61L2400/04C08J9/28C08J9/40C08J2201/0482C08J2201/0484C08J2305/04C08J2305/08C08J2389/00C08J2405/04
Inventor 石恒冲刘琳孙振龙栾世方殷敬华
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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