Unlock instant, AI-driven research and patent intelligence for your innovation.
A kind of preparation method of medical implant material with titanium dioxide metal porphyrin coating
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of metalloporphyrins and implant materials, which is applied in the direction of medical preparations, coatings, and pharmaceutical formulas containing active ingredients, to achieve the effects of improved capture, enhanced sterilization, and good biocompatibility
Inactive Publication Date: 2021-06-08
SOUTHWEST JIAOTONG UNIV
View PDF0 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0032] step 1:
[0033] The surface of the pretreated medical titanium or titanium alloy sample was prepared by micro-arc oxidation technology Ti0 2 Nano coating:
[0034] 101: Cut the Ti slices into Ti slices with a diameter of 1 cm and a thickness of 1.5 mm, then polish them with sandpaper, and then use acetone, ethanol, and deionized water to ultrasonically clean them in an ultrasonic machine. Then acid treatment. The concentration of acid treatment is (4% HF, 44% HNO3), then put into deionized water for ultrasonic cleaning, and finally dry for later use.
[0035] 102: Micro-arc oxidation of Ti0 2 , in a programmable high-precision constant-voltage DC power supply, graphite is used as the cathode, and Ti sheet is used as the anode. The voltage is 150V, the current is 2.5A, the concentration of sulfuric acid is 1mM, and the micro-arc oxidation time is 1min. Ultrasonic cleaning was carried out in deionized water, and dried for later use.
[0036] Step 2:
[0037] In sit...
Embodiment 2
[0046] step 1:
[0047] Preparation of Ti0 on the surface of medical titanium or titanium alloy samples to be treated 2 nanoporous coating;
[0048] 101: will The titanium wire is cut into 1.75cm titanium rod, and then ultrasonically cleaned in an ultrasonic machine with acetone, ethanol, and deionized water. This is followed by acid treatment. The concentration of acid treatment is (4% HF, 44% HNO3), then put into deionized water for ultrasonic cleaning, and finally dry for standby.
[0049] 102: Micro-arc oxidation of Ti0 2 , in a programmable high-precision constant-voltage DC power supply, graphite is used as the cathode, Ti rods are used as the anode, the voltage is 150V, the current is 2.5A, the concentration of sulfuric acid is 1mM, and the micro-arc oxidation time is 1min. Ultrasonic cleaning was carried out in deionized water, and dried for later use.
[0050] Step 2:
[0051] In-situ polymerization of a layer of polydopamine on the surface of Ti02 nano-coatin...
Embodiment 3
[0060] It is basically the same as step example 1, the modified part is that the voltage of step 101 is changed from 150V to 130V, the current from 2.5A is changed to 5A, the concentration of sulfuric acid is changed from 1mM to 2mM, and the temperature of step 3 is changed from 80°C to 100°C.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention discloses a method for preparing a medical implant material with a titanium dioxide metalloporphyrin coating, comprising the following steps: preparing Ti0 on the surface of a pretreated medical titanium or titaniumalloy sample by micro-arc oxidation technology 2 Nano-coating, and then the sample material is polymerized with a layer of polydopamine in the dopamine solution, and then the sample is placed in the precursor solution for metalloporphyrin organic framework synthesis, and the metalloporphyrin is grown in situ on the porous surface by induction of PDA Organic framework coating, and finally the obtained sample material is soaked in the osteoactive factor material solution for loading. The invention has the advantages of firm combination with the base, good biocompatibility, good photodynamic antibacterial effect and bone induction regeneration effect, strong operability, and good clinical application prospects as a medical deviceimplant material.
Description
technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a preparation method of a medical implant material with a titanium dioxidemetalporphyrin coating. Background technique [0002] Among biomedical metal materials, Ti and its alloys have gradually become the first choice for human hard tissue substitutes and restorations such as dental implants, bone planing products, and artificial joints due to their excellent biocompatibility and corrosion resistance. However, bacterial infection of implanted medical devices can lead to many health problems, and severe cases can lead to death. At the same time, good bone regeneration ability is also required after implanted devices. Osteogenic biocompatible implantable devices. The advent of antibiotics has saved many patients with bacterial infections, but long-term use of either natural antibiotics or synthetic antibiotics will lead to bacterial resistance and the e...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More