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Artificial cornea and preparation method thereof

An artificial cornea and a combined technology, applied in prostheses, eye implants, tissue regeneration, etc., can solve the problems of increasing oxygen and nutrient exchange, low oxygen permeability of artificial cornea, high melting rate of corneal stroma, etc., to increase oxygen Exchange, improve mechanical strength, reduce the effect of melting

Pending Publication Date: 2020-09-29
GUANGZHOU SUN SHING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention solves the problems of low oxygen permeability, high melting rate of corneal stroma and easy shedding of the existing artificial cornea, and invents the secondary polymerization integrated molding technology to prepare the artificial cornea with a porous sponge skirt bracket with macroscopic openings. Oxygen and nutrient exchange of the recipient tissue at the corneal skirt stent binding site, enhance the combination of the artificial corneal skirt stent and the recipient tissue, and improve its mechanical strength

Method used

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  • Artificial cornea and preparation method thereof
  • Artificial cornea and preparation method thereof
  • Artificial cornea and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] The mold used is attached figure 1 , configure a HEMA aqueous solution with a mass fraction of 15%, add 5% ethylene glycol dimethacrylate (EDMA) crosslinking agent, add 1% initiator ammonium persulfate (APS), mix well and add to mold A , cover the B mold, and react at room temperature for 24 hours. After the reaction finishes, the B mold is removed, and the mixed solution of HEMA / MMA is added, wherein the mass fraction of HEMA is 50%, the crosslinking agent is 5% EDMA, and the initiator is 2% azobisisobutyronitrile (AIBN), Cover mold C and heat to 60°C for 24 hours. Wherein mold B has 12 circular columns at the position corresponding to the skirt, with a diameter of 1mm, and the skirt of the obtained artificial cornea has 12 macroscopic holes with a diameter of 1mm. The schematic diagram of the obtained artificial cornea is as follows figure 2 shown.

Embodiment 2

[0026] The implementation method is attached figure 1 As shown, configure a HEMA aqueous solution with a mass fraction of 35%, add 10% ethylene glycol dimethacrylate (EDMA) crosslinking agent, add 0.5% azobisisobutyronitrile (AIBN), mix well and add In mold A, cover mold B and heat to 70°C for 24 hours. After the reaction, remove the mold B, add a mixed solution of HEMA / MMA, wherein the mass fraction of HEMA is 65%, the crosslinking agent is 1% EDMA, the initiator is 1% tert-butyl alcohol peroxide, and cover the mold C , and reacted at room temperature for 24 hours. Wherein mold B has 3 annular pillars at the position corresponding to the skirt, the width is 1mm, and the skirt of the obtained artificial cornea promptly has 3 macro grooves with a width of 1mm, and its structure is as attached image 3 shown.

Embodiment 3

[0028] The number of grooves and / or holes in the skirt bracket has been screened by experiments. The larger the number and the larger the size, the more oxygen and nutrients will be exchanged, but too large holes / slots will affect the mechanical strength of the skirt. Therefore, The design of the groove / hole should be based on the normal mechanical support that does not affect the artificial cornea. Therefore, skirts of different sizes were prepared by the method of Example 1 or Example 2, and the experimental results of mechanical strength testing are shown in Table 1. .

[0029] Table 1 Comparison table of tensile strength of skirt with different pore size, hole diameter and number of holes

[0030]

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Abstract

The invention solves the problems that an existing artificial cornea is low in oxygen permeation rate, high in cornea stroma melting rate and prone to falling off; a secondary polymerization integrated forming technology is invented; an artificial cornea with a porous sponge skirt support with macroscopic holes is prepared; oxygen and nutrient exchange of receptor tissue at the position of combination with the skirt support of the artificial cornea is increased; the combination between the skirt support of the artificial cornea and the receptor tissue is enhanced; and the mechanical strength of the artificial cornea is improved. The artificial cornea comprises an optical lens column and the skirt support, wherein the skirt support and the optical lens column are connected together throughan interpenetrating network, the skirt support is a PHEMA porous support, and a plurality of grooves and / or holes are formed in the skirt support. A preparation method of the artificial cornea is characterized by comprising the following steps of preparing the skirt support; and preparing an optical region to obtain the artificial cornea.

Description

technical field [0001] The invention relates to the field of medical consumables, in particular to an artificial cornea and a preparation method thereof. Background technique [0002] At present, in clinical treatment, usually after repeated allogeneic corneal transplantation failures, or in the case of alkali burns, lack of tears, severe corneal vascularization, etc., the only way to finally save and restore vision is artificial corneal transplantation. [0003] The currently commonly used artificial cornea is made of optically transparent materials such as polymethyl methacrylate or quartz glass, or it is used as the central mirror column material, and then equipped with a certain skirt fixing bracket to form an artificial cornea device, which participates in the vision of the patient. repair. Under normal circumstances, the preparation method of the above-mentioned artificial cornea is complicated, and the implantation operation needs to be performed several times. More ...

Claims

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Application Information

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IPC IPC(8): A61F2/14A61L27/16
CPCA61F2/142A61F2240/002A61L27/16A61L2430/16A61F2/15C08L33/12
Inventor 王涛曾晨光杨习锋丁雪玲
Owner GUANGZHOU SUN SHING BIOTECH CO LTD