Method for preparing high-bioavailability high-stability carotenoid preparation

A technology of carotene and high stability, which is applied in the direction of non-active ingredients of polymer compounds, medical preparations of non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problem that the effect is not obvious, the spray drying process is unfavorable, Increased energy consumption etc.

Inactive Publication Date: 2020-09-29
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to reduce the particle size, one method is to grind multiple times for a long time, which will not only greatly increase the energy consumption during production, but also have a bad effect on the stability of carotenoids; another method is to add a large amount of carotenoids to the formula Water or water-soluble solvents such as isopropanol, propylene glycol to reduce the viscosity during grinding, this method is not very effective, and it is not good for the subsequent spray drying process

Method used

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  • Method for preparing high-bioavailability high-stability carotenoid preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Take 475g of modified starch (PG 2000, purchased from Ingredion) and 25g of sucrose, and dissolve them completely in 580ml of hot water at 50°C to form a water-soluble colloid solution. Get beta-carotene crystal 15g, synthetic tocopherol 65g, join in above-mentioned colloidal solution (solid content 50%), carry out first grinding in sand mill (Sunller Machine), grinding medium yttrium stabilized zirconia bead diameter Between 0.6-0.8mm, after grinding for 0.3hr, take a sample and test, the beta-carotene particle size is 1.5μm, stop the grinding, and obtain the first-grade grinding liquid.

[0047] Weigh 25g of modified starch (PG 2000, Ingredion) and 475g of sucrose in the above-mentioned primary grinding liquid. After stirring and dispersing, enter the second sand mill (Sunller Machine) for the second grinding, and the grinding medium is yttrium-stabilized zirconia. The bead diameter is between 0.3-0.4mm. After grinding for 0.2hr, take a sample and test. The beta-carot...

Embodiment 2

[0049] Take 40g of gum arabic and 545g of maltodextrin, dissolve them completely in 3080ml of hot water at 75°C to form a water-soluble colloid solution, and cool down to 45°C. Get 125g of lutein crystals (wherein 115g of lutein crystals, content 80.7%, 10g of zeaxanthin, content 83.4%), natural vitamin E 40g, join in the above-mentioned colloid solution (solid content 19.6%), in sand mill (Sunller Machine) grinds for the first time, and the grinding medium yttrium-stabilized zirconia bead particle size is between 0.6-0.8mm, after grinding 1.0hr, sampling is detected, and the lutein particle size is 0.9 μm, stops grinding, obtains a grade grinding fluid.

[0050] Take by weighing 760g of gum arabic, 30g of syrup in the above-mentioned primary grinding liquid, after stirring and dispersing, enter the second sand mill (Sunller Machine) to grind for the second time, the particle size of the grinding medium yttrium stabilized zirconia beads is between 0.3- 0.4mm, after grinding f...

Embodiment 3

[0053]Take 200g of gelatin and 250g of sucrose, dissolve them completely in 2575ml of hot water at 70°C to form a water-soluble colloid solution, and cool down to 40°C. Get cantharidin crystal 185g (content 97.3%), ascorbyl palmitate 45g, join in the above-mentioned colloidal solution (solid content 20.9%), grind for the first time in sand mill (Sunller Machine), the grinding medium yttrium is stable The particle size of the zirconia beads is between 0.6-0.8 mm. After grinding for 0.5 hr, the particle size of the canthaxanthin particles is 1.5 μm, and the grinding is stopped to obtain a first-grade grinding liquid.

[0054] Weigh 250g of gelatin, 275g of maltodextrin, and 30g of ascorbic acid in the above-mentioned primary grinding liquid. After stirring and dispersing, enter the second sand mill (Sunller Machine) for the second grinding, and the grinding medium is yttrium-stabilized zirconia beads. The diameter is between 0.3-0.4mm. After grinding for 0.5hr, the particle size...

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Abstract

The invention provides a method for preparing a high-bioavailability high-stability carotenoid preparation. The method comprises the steps of dissolving part of water-soluble colloids and filling substances in water to form an aqueous phase, dispersing carotenoid crystals in the aqueous phase, carrying out primary grinding, then, supplementing the rest water-soluble colloids and filling substances, and carrying out secondary grinding, thereby obtaining a nano-disperse water-soluble suspension of carotenoid, wherein microcapsule dry powder or microparticles of the carotenoid can be prepared from the water-soluble suspension through a spray drying or spray congealing process as required. The method has the advantages that the carotenoid preparation is obtained through the twice-grinding twice-embedding process; the production process is short in grinding time and low in energy consumption; and liquid droplets in the end product reach nano-scale dispersion and are uniform in dispersion, small in particle size span, good in stability and easy in tabletting forming.

Description

technical field [0001] The invention relates to a method for producing carotenoid preparations by direct grinding. The obtained preparations have good stability and high bioavailability. The preparations can be water-soluble suspensions, and the water-soluble suspensions can also be granulated to obtain water-soluble suspensions as required. The invention relates to dry powder or granule, which belongs to the field of pharmaceutical preparations. [0002] technical background [0003] Carotenoids exist widely in nature. In 1831, Wachenroder first crystallized and isolated carbohydrate pigments from carrot roots, and named them "carotene"; afterward, Berzelius isolated and extracted yellow polar pigments from autumn leaves. Pigment, and named as "lutein"; with the development of biophysical technology, a series of natural pigments were separated by chromatographic methods, and named as "carotenoids". They have common chemical structure characteristics, the molecular center is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/015A61K31/047A61K31/01A61K31/122A61K47/36A61K47/42A61P9/10A61P13/08A61P35/00
CPCA61K9/5036A61K9/5052A61K9/5089A61K31/015A61K31/047A61K31/01A61K31/122A61P9/10A61P13/08A61P35/00A23L5/44A23L2/58A23P10/30A23L2/52A61K31/07A23L29/035A23L27/72A23P10/40A61K9/1658A61K9/1652A61K9/1694A61K9/1623B02C23/36
Inventor 许新德周迪谢恬叶双明王胜南
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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