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Process for improving quality and yield of collagen peptide coproduced from sodium chondroitin sulfate

A technology of chondroitin sulfate sodium and collagen peptides, which is applied in the direction of animal/human protein, peptide preparation methods, peptides, etc., and can solve the problems of affecting product yield and low yield

Pending Publication Date: 2020-10-20
HUNAN WUXING BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Limited to the use of fresh raw materials, raw material pretreatment, degreasing and de-meat and compound enzymatic hydrolysis affect product yield
Wherein the yield of chondroitin sulfate in the embodiment is 2.8%, and the yield of collagen peptide is 12%, and whole yield is still lower

Method used

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  • Process for improving quality and yield of collagen peptide coproduced from sodium chondroitin sulfate
  • Process for improving quality and yield of collagen peptide coproduced from sodium chondroitin sulfate
  • Process for improving quality and yield of collagen peptide coproduced from sodium chondroitin sulfate

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Embodiment 1

[0041] This embodiment includes the following steps:

[0042] A process for improving the quality of sodium chondroitin sulfate co-produced collagen peptides, comprising the following steps:

[0043] (1) Carbon dioxide supercritical extraction cartilage degreasing: crush 1000kg of dried bovine nasal bone to obtain cartilage coarse powder, use carbon dioxide supercritical extraction to crush the cartilage coarse powder, extract the lipophilic substances such as oil, choose continuous downstream extraction method, 200kg / Batch, flow rate 500 liters / hour, temperature 40 degrees, pressure 12mpa, 4 hours / batch, obtain defatted cartilage, receive 30 kilograms of grease.

[0044] (2) Hydrolysis: put the degreased cartilage obtained in step (2) into an extraction tank, add 8 tons of water, keep warm at 105°C for 2 hours; start stirring at a speed of 120 rpm, cool to 50°C; adjust the speed to 60 rpm , add 2709 alkaline protease with 0.9% cartilage mass (90 kg), and enzymatically hydro...

Embodiment 2

[0049] Example 2 is the same except that butane subcritical extraction is used to replace carbon dioxide supercritical extraction.

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Abstract

A process for improving quality and yield of collagen peptide coproduced from sodium chondroitin sulfate comprises the following steps: (1) degreasing bovine cartilage by supercritical / subcritical extraction; (2) hydrolyzing, flocculating and separating endonuclease; (3) carrying out ultrafiltration to separate chondroitin sulfate sodium and collagen peptide; (4) refining the sodium chondroitin sulfate; and (5) refining the collagen peptide. The process is used for extracting the dried bovine cartilage chondroitin sulfate sodium and collagen peptide, meanwhile, the product yield and quality are improved, and the obtained product is white in color and luster and free of beef tallow smell. According to the process, the dried bovine bones are adopted, so that the problems that domestic bovinefeeding and slaughtering are scattered, and fresh bovine cartilage is high in storage, collection and transportation cost and high in difficulty are solved; and the process is simple in technologicalprocess, easy to filter, short in production time, capable of saving energy and reducing emission, low in production cost and remarkable in economic benefit and social benefit, and processes such asresin decoloration and ion exchange are not needed.

Description

technical field [0001] The invention belongs to the fields of health food and biochemical pharmacy, and specifically relates to a process for improving the quality and yield of collagen peptide co-produced by sodium chondroitin sulfate. Background technique [0002] Sodium chondroitin sulfate (CS for short) is an acidic mucopolysaccharide widely found in bovine bone, pork bone, chicken bone, shark bone, and squid bone. macromolecule. Sodium chondroitin sulfate is composed of 50-70 disaccharide units, the disaccharide units are formed by glucuronic acid and galactosamine through β-1,3 glycosidic bonds, and the disaccharides are connected by β-1,4 glycosidic bonds polymerize into macromolecules. [0003] Sodium chondroitin sulfate has physiological functions such as lowering blood fat, anticoagulation, anti-inflammation and anti-tumor. Clinically, it is mainly used as a treatment for osteoarthritis, hyperlipidemia, angina pectoris, atherosclerosis and other diseases. Its ey...

Claims

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Application Information

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IPC IPC(8): C08B37/08C12P21/06C07K14/78C07K1/36C07K1/34C07K1/30C07K1/14
CPCC07K14/78C08B37/0069C12P21/06Y02P20/54
Inventor 谭岸邹高远李爱斌谭金茂朱小丰曾国强邹敏宋永志朱仁丰
Owner HUNAN WUXING BIOLOGICAL TECH CO LTD
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