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Production formula and production method of erythromycin ointment

A technology for producing formula and erythromycin, which is applied in the directions of ointment delivery, pharmaceutical formula, medical preparations with inactive ingredients, etc., can solve the problems of poor transdermal absorption, poor drug action time, loss of active ingredients, etc. , to prevent damage, prolong the action time, and improve the effect of transdermal absorption

Inactive Publication Date: 2020-11-06
ANHUI AIKEER PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing erythromycin ointments have fewer ingredients in the formula, especially among which erythromycin compounds are mostly single erythromycin, the effect of drug release and transdermal absorption is not good, resulting in poor efficacy, and at the same time, the loss of active ingredients is serious , the drug action time is not good, for this reason, we propose a production formula and production method of erythromycin ointment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A production formula of erythromycin ointment, its raw materials are as follows by weight: 30 parts of erythromycin compound, 12 parts of zinc oxide, 8 parts of medicinal powder extract, 20 parts of base material, 5 parts of metronidazole and the remaining Measure water; the medicated powder of described medicated powder extract is the same quality mugwort, angelica, calamus, atractylodes atractylodes, cortex cortex, coix seed, coptis and licorice; the base material is the same quality glyceryl monostearate, stearyl alcohol , a mixture of 1,3-propanediol, glyceryl stearate citrate and water.

[0019] Specifically, the auxiliary material is a mixture of yellow petrolatum and soft liquid paraffin, wherein the ratio of yellow petrolatum and soft liquid paraffin is 4:6.

[0020] Specifically, the erythromycin compound is a mixture of erythromycin, erythromycin ethylsuccinate and erythromycin ethylsuccinate, wherein the ratio of erythromycin, erythromycin ethylsuccinate and ...

Embodiment 2

[0026] A production formula of erythromycin ointment, its raw materials are as follows by weight: 38 parts of erythromycin compound, 13 parts of zinc oxide, 10 parts of medicinal powder extract, 22 parts of base material, 8 parts of metronidazole and the remaining Measure water; the medicated powder of described medicated powder extract is the same quality mugwort, angelica, calamus, atractylodes atractylodes, cortex cortex, coix seed, coptis and licorice; the base material is the same quality glyceryl monostearate, stearyl alcohol , a mixture of 1,3-propanediol, glyceryl stearate citrate and water.

[0027] Specifically, the auxiliary material is a mixture of yellow petrolatum and soft liquid paraffin, wherein the ratio of yellow petrolatum and soft liquid paraffin is 4:6.

[0028] Specifically, the erythromycin compound is a mixture of erythromycin, erythromycin ethylsuccinate and erythromycin ethylsuccinate, wherein the ratio of erythromycin, erythromycin ethylsuccinate and...

Embodiment 3

[0034] A production formula of erythromycin ointment, its raw materials are as follows by weight part by weight: 46 parts of erythromycin compound, 14 parts of zinc oxide, 13 parts of medicinal powder extract, 25 parts of base material, 9 parts of metronidazole and the remaining Measure water; the medicated powder of described medicated powder extract is the same quality mugwort, angelica, calamus, atractylodes atractylodes, cortex cortex, coix seed, coptis and licorice; the base material is the same quality glyceryl monostearate, stearyl alcohol , a mixture of 1,3-propanediol, glyceryl stearate citrate and water.

[0035] Specifically, the auxiliary material is a mixture of yellow petrolatum and soft liquid paraffin, wherein the ratio of yellow petrolatum and soft liquid paraffin is 4:6.

[0036] Specifically, the erythromycin compound is a mixture of erythromycin, erythromycin ethylsuccinate and erythromycin ethylsuccinate, wherein the ratio of erythromycin, erythromycin eth...

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PUM

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Abstract

The invention discloses a production formula of erythromycin ointment. The erythromycin ointment is prepared from the following components in parts by weight raw material: 30 to 46 parts of erythromycin compound, 12 to 14 parts of zinc oxide, 8 to 13 parts of medicine powder extract, 20 to 25 parts of base material, 5 to 9 parts of metronidazole and the balance of water. The medicine powder of themedicine powder extract is prepared from artemisia argyi, radix angelicae dahuricae, acorus calamus, rhizoma atractylodis, cortex phellodendri, semen coicis, rhizoma coptidis and radix glycyrrhizae with the same mass; wherein the base material is a mixture of glyceryl monostearate, octadecanol, 1, 3-propylene glycol, glyceryl citrate stearate and water with the same mass. By adding the medicine powder extract and the erythromycin compound, the erythromycin ointment has the effects of resisting bacteria, killing bacteria, diminishing inflammation, promoting blood circulation, removing blood stasis and diminishing swelling, and the effects of medicine release and transdermal absorption are improved; zinc oxide has convergence and protection effects and can prevent the erythromycin ointmentfrom damaging the skin; by adding the base material, a water retention effect is achieved on the skin, loss of effective components of the medicine is prevented, and the action time of the medicine isprolonged.

Description

technical field [0001] The invention relates to the technical field of erythromycin ointment, in particular to a production formula and a production method of erythromycin ointment. Background technique [0002] Erythromycin ointment is an antibacterial drug, which mainly has antibacterial effect and belongs to the class of macrolide antibacterial drugs. Existing erythromycin ointments have fewer ingredients in the formula, especially among which erythromycin compounds are mostly single erythromycin, the effect of drug release and transdermal absorption is not good, resulting in poor efficacy, and at the same time, the loss of active ingredients is serious , the drug action time is not good, for this reason, we propose a production formula and production method of erythromycin ointment. Contents of the invention [0003] The purpose of the present invention is in order to solve the shortcoming that exists in the prior art, and proposes a kind of production prescription of...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/8994A61K9/06A61K47/14A61K47/10A61P31/04A61P29/00A61K33/30A61K31/4164
CPCA61K9/06A61K31/4164A61K31/7048A61K33/30A61K36/232A61K36/282A61K36/284A61K36/484A61K36/718A61K36/756A61K36/888A61K36/8994A61K47/10A61K47/14A61P29/00A61P31/04A61K2300/00
Inventor 盛暑溧
Owner ANHUI AIKEER PHARMA CO LTD
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