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Coating premix containing cyclodextrin and preparation method thereof

A technology for coating a premix and cyclodextrin, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, and pill delivery, etc., can solve the problems of cumbersome preparation methods, unfavorable administration for diabetics, and the like, Achieve the effects of good emulsion stability, low mold and Escherichia coli content, and controllable process

Inactive Publication Date: 2020-11-06
嘉兴市爵拓科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a large amount of lactose is used in this method, and the coated drug prepared by it is obviously not conducive to the administration of diabetics, and the inventive method contains a barrier layer and an enteric layer coating, and the preparation method is relatively cumbersome

Method used

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  • Coating premix containing cyclodextrin and preparation method thereof
  • Coating premix containing cyclodextrin and preparation method thereof
  • Coating premix containing cyclodextrin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1: A kind of coating premix containing cyclodextrin:

[0070] This embodiment provides a coating premix containing cyclodextrin, which includes the following components and their weights:

[0071]

[0072]

[0073] Specifically, the coating premix containing cyclodextrin described in this example was prepared through the following steps:

[0074] 1) Preparation of methyl methacrylate / butyl methacrylate copolymer emulsion:

[0075] 1.1) Mix 2.5g nonylphenol polyoxyethylene ether and 10.0g cetyltrimethylammonium bromide evenly, add 1000g deionized water and stir evenly to prepare a composite emulsifier system;

[0076] 1.2) 1mol methyl methacrylate and 1.5mol butyl methacrylate are mixed evenly and then slowly added to the compound emulsifier system in step 1) for pre-emulsification for 75min;

[0077] 1.3) To prepare a 2.0% potassium persulfate aqueous solution, first add 14 g of potassium persulfate aqueous solution to the system of step 1.2) at one...

Embodiment 2

[0088] Example 2: Another coating premix containing cyclodextrin:

[0089] This example provides another coating premix containing cyclodextrin, its components, proportions, and preparation methods are basically the same as in Example 1, the only difference is that the following composition and The polyacrylic resin obtained by the preparation method replaces the methyl methacrylate / butyl methacrylate copolymer emulsion and supplements the amount of water in the emulsion with deionized water:

[0090]100g of methacrylic acid, 20g of ethyl acrylate, 80g of butyl acrylate, 0.5g of potassium persulfate, 0.03g of nonoxynyl alcohol, 1.0g of sodium lauryl sulfate, 4.0g of polysorbate 80, 482g of purified water; its preparation The method steps are as follows: Weigh purified water, potassium persulfate, nonoxynyl polyol 10, sodium lauryl sulfate and polysorbate 80 into the reaction kettle, stir the reaction kettle at 120r / min, heat the reaction kettle within 20min to 90°C; weigh m...

Embodiment 3

[0091] Example 3: Another coating premix:

[0092] This example provides another coating premix, its components, proportions, and preparation methods are basically the same as in Example 2, the only difference is that neither tyrosine-modified cyclodextrin is added in this example No threonine-modified cyclodextrin was added.

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Abstract

The invention relates to the technical field of novel coating materials and particularly relates to a coating premix containing cyclodextrin and a preparation method thereof. The coating premix containing cyclodextrin is prepared from the following components: methyl methacrylate / butyl methacrylate copolymer emulsion, amino acid modified cyclodextrin, plasticizer, an anti-sticking agent, a coloring agent, surfactant and other additives, wherein the amino acid modified cyclodextrin is prepared from tyrosine modified cyclodextrin and threonine modified cyclodextrin in a weight ratio of (5.2-6.0):1. The coating solution prepared from the coating premix has a good film forming performance, high film toughness and high strength, does not contain sugar ingredient, is favorable to application ofpatients suffering from diabetes mellitus and other glycometabolisms; and a coating agent prepared from the coating premix has flexible and smooth outside, is favorable to application of patients withrelatively small oral cavity and esophagus, is stable in property, is insoluble in gastric juice and can quickly release in intestinal juice.

Description

technical field [0001] The invention relates to the technical field of novel coating materials, in particular to a coating premix containing cyclodextrin and a preparation method thereof. Background technique [0002] Coating is to apply sugar or other film-forming materials on the outer surface of the solid pharmaceutical preparation in specific equipment according to a specific process, and make it dry to form one or several layers of different thicknesses closely adhered to the surface. , Multi-functional protective layer with different elasticity. With the improvement of the level of pharmaceutical preparations, the continuous application of new pharmaceutical excipients and new technologies, the coating of pharmaceuticals has also undergone the evolution from sugar coating to film coating. Film coating is a coating technology developed in the early 1950s. Due to its advantages of good stability, short coating time, less weight gain, and good moisture resistance, it has...

Claims

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Application Information

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IPC IPC(8): A61K47/40A61K47/32A61K47/18A61K9/36A61K9/32A61K9/30A61K31/616C08F220/18C08F220/14C08F2/26C08F2/30C08B37/16
CPCA61K9/282A61K9/2846A61K9/286A61K31/616C08B37/0012C08F2/26C08F2/30C08F220/1804C08F220/14
Inventor 不公告发明人
Owner 嘉兴市爵拓科技有限公司
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