Bone repair material and preparation method thereof

A technology for bone repair and material composition, applied in the field of medical biomaterials, can solve the problems of artificial joint loosening, high brittleness of CSC, inflammatory reaction, etc., and achieve the effect of avoiding excessive elastic modulus and quickly repairing bone defects

Active Publication Date: 2021-12-17
上海禾麦医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the current bone cements in clinical use have their own shortcomings that are difficult to overcome: for example, PMMA has heat accumulation reaction, no bone conduction, and cannot be degraded and absorbed; CPC has a long curing time, low mechanical strength, and slow degradation rate; CSC is brittle. , low strength, too fast degradation, acidic degradation products, leading to inflammatory reactions, etc.
In addition, bone cement is different from human bones after all. Over time, artificial joints may still loosen

Method used

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  • Bone repair material and preparation method thereof
  • Bone repair material and preparation method thereof
  • Bone repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Formula: 6MgO+ Ca(H 2 PO 4 ) 2 + 4NaH 2 PO 4 +Calcium deficiency HA (20%)

[0104] The preparation method of bone cement composite bone repair material comprises the following steps:

[0105] (1) Dissolve calcium-deficient hydroxyapatite particles into 200 μmol / L deferoxamine solution, stir for 2 hours, and then centrifuge and dry to obtain the required drug-loaded calcium-deficient hydroxyapatite particles;

[0106] (2) According to the above formula, uniformly mix magnesium oxide, calcium dihydrogen phosphate, sodium dihydrogen phosphate and calcium-deficient hydroxyapatite to obtain bone cement powder;

[0107] (3) Mix the bone cement powder and EGCG solidification solution (120 μmol / L) at a ratio of 0.55 g / 100 mg, and place them in a mold at 37°C and 100% humidity after solidification (setting time is 6-10 min). It can be cured for 72 h under ambient conditions.

[0108] In bone cement composite bone repair materials, the particle size of calcium-deficient h...

Embodiment 2

[0110] Formula: 5MgO+ Ca(H 2 PO 4 ) 2 + 3NaH 2 PO 4 +Calcium deficiency HA (20%)

[0111] The preparation method of bone cement composite bone repair material comprises the following steps:

[0112] (1) Dissolve calcium-deficient hydroxyapatite particles into 200 μmol / L deferoxamine solution, stir for 2 hours, and then centrifuge and dry to obtain the required drug-loaded calcium-deficient hydroxyapatite particles;

[0113] (2) According to the above formula, uniformly mix magnesium oxide, calcium dihydrogen phosphate, sodium dihydrogen phosphate and calcium-deficient hydroxyapatite to obtain bone cement powder;

[0114] (3) Mix bone cement powder and EGCG solidification solution (120 μmol / L) at a ratio of 0.55 g / 120 mg, and place them in an environment of 37°C and 100% humidity after solidification in the mold (setting time is 6-10 minutes). It can be cured for 72 h.

[0115] In bone cement composite bone repair materials, the particle size of calcium-deficient hydroxya...

Embodiment 3

[0117] Formula: 3MgO+ Ca(H 2 PO4) 2 + NaH 2 PO 4 + Calcium-deficient HA (0%, 10% or 20%)

[0118] The preparation method of bone cement composite bone repair material comprises the following steps:

[0119] (1) According to the above formula, uniformly mix magnesium oxide, calcium dihydrogen phosphate, sodium dihydrogen phosphate and calcium-deficient hydroxyapatite to obtain bone cement powder;

[0120] (2) Evenly mix deferoxamine powder and bone cement powder;

[0121] (3) Mix deferoxamine-containing bone cement powder with EGCG solidification solution (120 μmol / L) at a ratio of 0.55 g / 150 mg, and put it in the mold at 37°C after solidification (setting time is 6-10 min). It can be cured for 72 h under the environment of 100% humidity.

[0122] In bone cement composite bone repair materials, the particle size of calcium-deficient hydroxyapatite is 3-5 µm.

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Abstract

The invention discloses a bone repair material, its preparation method and application. The raw material composition comprises the following components: magnesium oxide, calcium dihydrogen phosphate, sodium dihydrogen phosphate and calcium-deficient hydroxyapatite. The molar ratio of magnesium oxide, calcium dihydrogen phosphate, and sodium dihydrogen phosphate bone cement powder is 6:1:4, 5:1:3 or 3:1:1, of which calcium-deficient hydroxyapatite accounts for 20% of the total mass . The solidification solution of bone cement was EGCG aqueous solution with a concentration of 120 μmol / L. The medicine contained is deferoxamine. The preparation method of the bone repair material of the present invention is simple and easy; the solidification time is suitable, and it has good biocompatibility, osteogenesis and degradability, can promote the adhesion, proliferation and differentiation of osteoblasts, and can stimulate cell growth, Stimulates the differentiation of osteoblasts into bone cells; it can be injected directly into bone defects.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a bone repair material and a preparation method thereof. Background technique [0002] With the aging of the population and the increase of trauma among middle-aged and young people, bone repair materials have become one of the biomedical materials with the greatest clinical demand. Bioactive ceramics have been widely used clinically as bone filling and repair materials, but these materials are in the form of lumps or granules after high-temperature sintering and do not have plasticity. During the operation, doctors cannot arbitrarily shape the bone defect of the patient, and cannot completely fill the cavity of the deformed bone. On the other hand, the fixation of artificial joints and the internal fixation of unstable fractures also require a new biomedical material. Therefore, a new type of biological material - bone cement has become a hot spot of concern. [0003] The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/50A61L27/54A61L27/56A61L27/58A61K31/16A61K31/353A61P19/08A61P19/10A61P31/04
CPCA61L27/12A61L27/025A61L27/50A61L27/54A61L27/56A61L27/58A61K31/16A61K31/353A61K9/0019A61P19/08A61P19/10A61P31/04A61L2300/412A61L2430/02A61L2300/404A61L2400/06A61L2300/204A61L2300/602A61L2300/216A61K2300/00
Inventor 苏佳灿胡衍魏杰黄标通
Owner 上海禾麦医学科技有限公司
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