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Whitening and freckle-removing composition, whitening and freckle-removing soluble microneedle patch and preparation method thereof

A whitening and freckle-removing and soluble technology, applied in the field of microneedle, can solve the problems of insignificant whitening and freckle-removing effect, poor stability, poor permeability, etc., and achieve the effects of fast and lasting whitening and freckle removal, balanced hardness and good mechanical strength

Active Publication Date: 2020-11-13
广州新济薇娜生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the skin is a complex tissue structure, and the stratum corneum is the main barrier for active ingredients to penetrate, so that most ingredients, especially water-soluble ingredients, cannot penetrate into the subcutaneous tissue to play a role
Common and effective skin whitening agents all have the problems of poor skin permeability and poor stability in water or air. Adding them to traditional cosmetic formulations such as ointment, cream, water, milk, etc. cannot exert their maximum effect, and the effect of whitening and lightening spots is not good. not obvious

Method used

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  • Whitening and freckle-removing composition, whitening and freckle-removing soluble microneedle patch and preparation method thereof
  • Whitening and freckle-removing composition, whitening and freckle-removing soluble microneedle patch and preparation method thereof
  • Whitening and freckle-removing composition, whitening and freckle-removing soluble microneedle patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Investigate the stability of the clathrate solution of oxidized resveratrol and resveratrol. The specific operation method is: weigh oxidized resveratrol and resveratrol according to the mass ratio of 2:1, and use ethanol with a mass fraction of 60%. The aqueous solution is prepared into a series of mixed solutions of oxidized resveratrol and resveratrol with mass fractions of 1%, 2%, 3%, 4%, and 5%, respectively, and is recorded as solutions A1, A2, A3, A4, and A5 ; Take a certain amount of hydroxypropyl-β-cyclodextrin, and prepare it with water to make an aqueous solution with a mass fraction of 5%, which is designated as solution B. Take 5 cups of solution B on the magnetic stirrer, slowly drop into solutions A1, A2, A3, A4, A5 according to 1 / 3 of the amount of solution B while stirring, so that the mass fraction of the clathrate is 0.25%, 0.25%, 0.5%, 0.75%, 1%, 1.25% oxidized resveratrol and clathrate solution of resveratrol, the clathrate refers to oxidized resver...

Embodiment 2

[0080] This embodiment provides whitening and anti-freckle dissolvable microneedle patches loaded with 1% oxidized resveratrol (such as image 3 shown), the microneedle patch will form a viscous liquid with oxidized resveratrol and resveratrol inclusion liquid, small molecular substances, microneedle framework materials and solvents. Under negative pressure environment, The viscous liquid is coated on the microneedle mold and dried.

[0081] The preparation method of the whitening and freckle-removing soluble microneedle patch loaded with oxidized resveratrol provided in this example comprises the following steps:

[0082] (1) Preparation of clathrate solution of oxidized resveratrol and resveratrol: take oxidized resveratrol and resveratrol in a mass ratio of 2:1, and prepare a mass fraction of 1.5% solution A; take a certain amount of hydroxypropyl-beta cyclodextrin, and water is configured into solution B with a mass fraction of 5%; under magnetic stirrer stirring, 46.62g ...

Embodiment 3

[0087] This example provides a method for preparing a whitening and freckle-removing soluble microneedle patch loaded with 2% oxidized resveratrol. The microneedle patch combines oxidized resveratrol and resveratrol inclusion solution with small molecular substances, The microneedle framework material and solvent form a viscous liquid, which is obtained by coating the viscous liquid on the top of the microneedle mold under negative pressure and drying.

[0088] The preparation method of the whitening and freckle-removing soluble microneedle patch loaded with oxidized resveratrol provided in this example comprises the following steps:

[0089] (1) Preparation of clathrate solution of oxidized resveratrol and resveratrol: take oxidized resveratrol and resveratrol in a mass ratio of 2:1, and prepare a mass fraction of 1.5% solution A; take a certain amount of hydroxypropyl-beta cyclodextrin, and water is configured into solution B with a mass fraction of 5%; under magnetic stirre...

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Abstract

The invention relates to a whitening and freckle-removing composition, a whitening and freckle-removing soluble microneedle patch and a preparation method of the whitening and freckle-removing solublemicroneedle patch. The whitening and freckle-removing composition is prepared from oxyresveratrol, resveratrol and small molecular substances, wherein the micromolecular substance is prepared from the following components in parts by weight: 40 to 50 parts of alpha-arbutin, 40 to 50 parts of glutathione and 1 to 3 parts of soy isoflavone, and the ratio of the total mass of the oxyresveratrol andthe resveratrol to the mass of the micromolecular substance is 1 to (1 to 10). The whitening and freckle-removing soluble microneedle patch is prepared from viscous liquid composed of oxidized resveratrol and inclusion liquid of resveratrol, small molecular substances, a microneedle framework material and a first solvent, wherein the inclusion liquid of the oxidized resveratrol and the resveratrolis prepared from the oxidized resveratrol, the resveratrol, hydroxypropyl-beta cyclodextrin and a second solvent. The whitening and freckle-removing soluble microneedle patch has excellent mechanicalproperties and good whitening and freckle-removing effects.

Description

[0001] field of invention [0002] The invention belongs to the field of microneedles, and in particular relates to a whitening and freckle-removing composition, a whitening and freckle-removing soluble microneedle patch and a preparation method thereof. Background technique [0003] Pigmentation is a general term for all dark spots on the skin due to the stimulation of various internal and external factors. Most of them belong to brown or black pigmentation plaques formed by the increase or slow elimination of melanin synthesis on the surface of the skin. Pigmentation occurs mostly on the cheeks and forehead, seriously affecting the beauty of the face. With the improvement of living standards, people's pursuit of beauty has become more intense. In my country, there is a saying called "one white covers three ugliness", which reflects the admiration of Chinese consumers for white, and also gave birth to the growth of whitening and freckle products. Whitening and anti-freckle p...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61K8/64A61K8/34A61K8/49A61K8/73A61K8/81A61Q19/02A61M37/00
CPCA61K8/602A61K8/64A61K8/347A61K8/498A61K8/735A61K8/731A61K8/817A61K8/345A61Q19/02A61M37/0015A61K2800/805A61K2800/592A61M2037/0023A61M2037/0053A61M2037/0061
Inventor 温新国张敏敏冯家颖陈航平陈叶盛杨思超
Owner 广州新济薇娜生物科技有限公司
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