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Anticoagulant intravascular stent coating and preparation method thereof

A vascular stent and coating technology, applied in the field of anticoagulant tube stent coating and its preparation, can solve the problem of low hirudin content, and achieve the effects of long-lasting anticoagulation activity and excellent biomechanical properties

Active Publication Date: 2020-12-08
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has been found that the improvement of anticoagulant performance has been realized, the content of stably combined hirudin is still very low. Development of an anticoagulant stent graft

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0023] The invention provides a method for preparing an anticoagulant stent coating, comprising:

[0024] Step 1, preparing degummed silkworm silk fibers and cooked silk threads:

[0025] Select 40-160D (preferably 120D) silk thread and silk monofilament, the silk thread is obtained by twisting and merging silkworm raw silk, put the silk monofilament and silk thread into the deionized boiled in water for 7 hours at a temperature of 98-100°C, and the deionized water was replaced several times during the boiling period until the deionized water fully cleaned the silk monofilaments and silk threads, and then the Said silk monofilaments and silk threads are dried in an oven at a temperature of 60° C. to obtain degummed silkworm fibroin fibers and cooked silk threads.

[0026] Step 2, preparing silkworm silk fibroin aqueous solution:

[0027]The degummed silkworm silk fibers were dissolved in 9.3M lithium bromide aqueous solution at a bath ratio of 1:10 (g / mL), and treated at a t...

Embodiment 1

[0042] This implementation case shows a method for preparing an anticoagulant stent coating, including:

[0043] 1. Twisting and merging silkworm raw silk to obtain a 120D silk group, and the other group is a silk monofilament group. Put the silk monofilament and silk thread into deionized water at a bath ratio of 1:50 (g / mL), and dissolve them at 98-100 Boiling for 7 hours at ℃, changing the deionized water several times during the period, then fully cleaning the silk with deionized water, and drying it in an oven at 60 ℃ to obtain degummed silkworm silk fiber and cooked silk thread.

[0044] 2. Weigh the degummed silkworm silk fiber and dissolve it in 9.3M lithium bromide aqueous solution at a bath ratio of 1:10 (g / mL), and treat at 65°C until the silkworm silk fiber is completely dissolved to obtain silkworm silk fibroin solution. The silkworm fibroin solution is poured into the dialysis bag. The wall of the dialysis bag is a semipermeable membrane with a molecular weight c...

Embodiment 2

[0052] This implementation case shows a method for preparing an anticoagulant stent coating, including:

[0053] 1. Twisting and merging silkworm raw silk to obtain a 120D silk group, and the other group is a silk monofilament group. Put the silk monofilament and silk thread into deionized water at a bath ratio of 1:50 (g / mL), and dissolve them at 98-100 Boiling for 7 hours at ℃, changing the deionized water several times during the period, then fully cleaning the silk with deionized water, and drying it in an oven at 60 ℃ to obtain degummed silkworm silk fiber and cooked silk thread.

[0054] 2. Weigh the degummed silkworm silk fiber and dissolve it in 9.3M lithium bromide aqueous solution at a bath ratio of 1:10 (g / mL), and treat at 65°C until the silkworm silk fiber is completely dissolved to obtain silkworm silk fibroin solution. The silkworm fibroin solution is poured into the dialysis bag. The wall of the dialysis bag is a semipermeable membrane with a molecular weight c...

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Abstract

The invention discloses an anticoagulant intravascular stent coating and a preparation method thereof. The preparation method comprises the following steps: dividing silkworm silk into two groups, twisting and combining one group of silkworm silk to obtain a silk thread group, taking the other group of silkworm silk as a monofilament group, boiling the silk thread group and the monofilament groupby using deionized water for degumming, and weaving the silk thread group into a tubular structure by using a braiding machine, dissolving silk of the monofilament group in a lithium bromide neutral salt solution to prepare a silk fibroin dissolving solution, pouring the silk fibroin dissolving solution into a dialysis bag and placing in a container containing deionized water for continuous dialysis, obtaining a purified silkworm silk fibroin aqueous solution, then concentrating the silk fibroin aqueous solution through a rotary evaporator, and obtaining the silk fibroin aqueous solution; adding a proper amount of cross-linking agent into the silk fibroin aqueous solution for reaction, coating or spinning the tubular structure with the coating or spinning coating, spinning the coating withhirudin again after hot air spinning and air drying, and spinning and air drying at room temperature to obtain the anticoagulant intravascular stent coating. The coating has excellent biomechanical properties and lasting anticoagulant activity.

Description

technical field [0001] The invention relates to the technical field of preparation of vascular stent coatings, in particular to an anticoagulant vascular stent coating and a preparation method thereof. Background technique [0002] With the improvement of living standards and the acceleration of the aging process, the incidence of cardiovascular and cerebrovascular diseases is increasing significantly year by year. Cardiovascular and cerebrovascular diseases such as embolism, vascular stenosis, and vascular aneurysm seriously threaten human health and have become human mortality. highest etiology. With the development of medicine, minimally invasive endovascular isolation has gradually become the main treatment method for various arterial lesions due to the small surgical trauma. Vascular covered stent is the main body of endoluminal isolation, and its performance directly affects the clinical treatment effect. However, complications such as slippage of vascular covered ste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16A61L27/34A61L27/54A61L27/58A61L33/12C07K14/435
CPCA61L31/10A61L31/16A61L31/14A61L31/148A61L33/128A61L27/34A61L27/54A61L27/58C07K14/43586A61L2300/252A61L2300/42A61L2300/606A61L2300/412A61L2420/06A61L2420/08C08L89/00
Inventor 王建南戴梦男宋广州裔洪根
Owner SUZHOU UNIV
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