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Pyrazinamide compound, preparation method and application thereof, and bactericide

A technology of pyrazinamide and fungicide, applied in the field of pesticide preparation, can solve the problems of unsatisfactory killing effect of soil-borne pathogenic fungi

Pending Publication Date: 2020-12-08
QINGDAO HAOLITE BIOLOGICAL PESTICIDE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although pyrazinamide compounds are broad-spectrum fungicides, their killing effect on soil-borne pathogenic fungi is not ideal, and there is an urgent need to develop a compound pyrazinamide fungicide composition that can be synergistic

Method used

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  • Pyrazinamide compound, preparation method and application thereof, and bactericide
  • Pyrazinamide compound, preparation method and application thereof, and bactericide
  • Pyrazinamide compound, preparation method and application thereof, and bactericide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Drugs for testing:

[0022] 6-Chloro-N-(3-chlorophenyl)pyrazine-2-carboxamide (Jiangsu Aikang Biomedical Research and Development Co., Ltd.); the compound represented by formula I was prepared according to the preparation method of patent 201710953310.9.

[0023] Soil samples for testing:

[0024] Soil samples were collected in Cangzhou, Hebei, where nematodes and diseases are serious all the year round. Soil from the plow layer was taken through a 2mm sieve and mixed for later use. After analysis, the soil water content is 28.76%, pH6.77, soil organic matter content is 5.8%, NH 4+ -N 17.2mg / kg, NO 3- -N 121.1mg / kg, available phosphorus 533.8mg / kg, available potassium 622.1mg / kg.

[0025] Evaluation indicators and methods:

[0026] Alternaria, isolated by PDA medium;

[0027] Fusarium chlamysporum, isolated using Komada medium;

[0028] Rhizopus microsporin, isolated by PDA medium;

[0029] Ralstonia solanacearum was isolated using LB medium.

[0030] Weigh 500g...

Embodiment 2

[0051] A preparation method of pyrazinamide fungicides, carried out according to the following steps:

[0052] (1) According to parts by weight, get 6 parts of 6-chloro-N-(4-phenoxyphenyl) pyrazine-2-carboxamide, 4 parts of compounds shown in formula I, 25 parts of Nongru 400#, 25 parts of propylene glycol, 250 parts of water, mix well;

[0053] (2) finely emulsify the mixed solution mixed in step (1) by high-pressure homogenization to obtain a fine emulsion; the pressure of the high-pressure homogenization is 800 Pa, and the time for high-pressure homogenization is 30 min;

[0054] (3) Add 50 parts of calcium carbonate and 30 parts of carboxymethyl cellulose, mix well, and prepare.

Embodiment 3

[0056] A preparation method of pyrazinamide fungicides, carried out according to the following steps:

[0057] (1) According to parts by weight, get 4 parts of 6-chloro-N-(4-phenoxyphenyl) pyrazine-2-carboxamide, 6 parts of compounds shown in formula I, castor oil polyoxyethylene ether- 40 22 parts, 22 parts of rosin polyol ester, 220 parts of water, mix well;

[0058] (2) finely emulsify the mixed solution mixed in step (1) by high-pressure homogenization to obtain a fine emulsion; the pressure of the high-pressure homogenization is 1000 Pa, and the time for high-pressure homogenization is 25 min;

[0059] (3) Add 35 parts of calcined kaolin and 30 parts of polylactic acid, mix well, and prepare.

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Abstract

The invention discloses a pyrazinamide compound, a preparation method and application thereof and a bactericide. The pyrazinamide bactericide comprises the following active components: 6-chloro-N-(3-chlorphenyl)pyrazine-2-formamide and a compound shown as a formula I. The pyrazinamide bactericide disclosed by the invention can effectively kill harmful bacteria in soil; and the 6-chloro-N-(3-chlorphenyl)pyrazin-2-formamide and the compound shown as the formula I are mixed for use, so that a synergistic effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of pesticide preparation, and in particular relates to a pyrazinamide compound, a preparation method and application thereof, and a fungicide. Background technique [0002] Pyrazinamide is a white or off-white crystalline powder, which has good antibacterial effect on Mycobacterium tuberculosis, and has the strongest bactericidal effect at pH 5-5.5. The inhibitory concentration in the human body is 12.5μg / ml, up to 50μg / ml can kill Mycobacterium tuberculosis. [0003] With continuous research, pyrazinamide compounds have more and more bactericidal effects, which are broad-spectrum bactericidal, and can prevent powdery mildew, scab, gray mold on rice, fruits and vegetables in agriculture , Sclerotinia, ring spot, fruit spot and money spot etc. Although pyrazinamide compounds have broad-spectrum fungicides, their killing effect on soil-borne pathogenic fungi is not satisfactory, and it is urgent to develop a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D241/24A01N43/60A01N25/04A01P3/00A01P1/00
CPCC07D241/24A01N43/60A01N25/04
Inventor 贾学杰徐兴军丁竹叶李敬义
Owner QINGDAO HAOLITE BIOLOGICAL PESTICIDE
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