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Composition and preparation method thereof

A technology of composition and medicine, which is applied in the field of immunity-enhancing composition and its preparation, can solve problems such as low human immunity, and achieve the effect of safe and effective consumption, good health care effect, and no incompatibility

Inactive Publication Date: 2020-12-11
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above-mentioned problem of low human immunity, the present invention provides a composition and a preparation method thereof

Method used

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  • Composition and preparation method thereof
  • Composition and preparation method thereof
  • Composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1. Selection of extraction process

[0042] Take 80g of Cistanche medicinal material, 80g of Astragalus medicinal material, 80g of medlar medicinal material, and 80g of Ligustrum lucidum medicinal material in each part, take 9 parts in total, extract according to the relevant parameter requirements of factor level table 1, and measure echinacoside and verbascoside, astragalus in the extract glycoside transfer rate and crude polysaccharide content. Taking echinacoside, verbascoside, transfer rate of astragaloside IV and crude polysaccharide content as the investigation index, L 9 (3 4 ) Orthogonal test to investigate the amount of extraction solvent, extraction time, and extraction times.

[0043] Table 1 Factor levels

[0044]

[0045] Table 2L 9 (3 4 ) Orthogonal table (echinacoside, verbascoside)

[0046]

[0047]

[0048] Table 3 variance analysis table (echinacoside, verbascoside)

[0049]

[0050] Table 4 L 9 (3 4 ) Orthogonal Table (Astragalos...

Embodiment 2

[0067] 1. Extraction, concentration and drying process of medicinal materials

[0068] Weigh 3.0 kg of Cistanche deserticola, 3.0 kg of Astragalus membranaceus, 3.0 kg of Ligustrum lucidum and 3.0 kg of Lycium barbarum according to the proportion, add 1200 L of water, and reflux extraction twice, each time for 1.0 h. After filtration, the filtrate was concentrated under reduced pressure at 60°C to obtain a concentrated thick paste with a relative density of 1.25. Continue drying under reduced pressure at 70°C, crush, pass through a 65-mesh sieve, and make dry cream powder, the weight of which is 7.95kg.

[0069] 2. Selection of types and dosage of excipients

[0070] 2.1 Selection of types of excipients

[0071] After experimental research, it is necessary to add appropriate excipients to overcome problems such as caking, poor fluidity, large difference in grain weight, and difficulty in disintegration during the preparation process. In the selection process of the diluent,...

Embodiment 3

[0097] Weigh 54kg of Cistanche deserticola, 54kg of Astragalus membranaceus, 54kg of Ligustrum lucidum and 54kg of Lycium barbarum according to the proportion, add 2160L of water, and reflux extraction twice, each time for 1.0h. After filtering, the filtrate was concentrated under reduced pressure at 70°C to obtain a concentrated thick paste with a relative density of 1.20. Continue to dry under reduced pressure at 70°C for 5 hours, pulverize, pass through a 65-mesh sieve, and make a dry cream powder. The weight of the dry cream powder is 47.73kg, and then add auxiliary materials in proportion to the dry cream powder, and add microcrystalline cellulose 9.82kg, add 5.04kg of cornstarch, mix well, moisten with 90% ethanol, pass through a 20 mesh sieve, granulate, dry at 60°C for 5 hours, pass through a 20 mesh sieve, granulate, add disintegrant cross-linked carboxymethyl to the granules Sodium cellulose 1.92kg and lubricant 1.30kg are mixed to obtain about 63.24kg of particle we...

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Abstract

The invention provides a composition. The composition is prepared from the following components in parts by weight of 1 to 8 parts of herba cistanche, 1 to 8 parts of radix astragali seu hedysari, 1 to 8 parts of fructus ligustri lucidi and 1 to 8 parts of fructus lycii. The medicinal materials of the composition supplement each other and can be taken as a health-care product for a long time. Pharmacodynamic experiments prove that the composition can significantly enhance the delayed allergic reaction and carbon clearance phagocytic index of mice and enhance the phagocytic function of peritoneal macrophages, and has the effect of significantly enhancing immunity.

Description

technical field [0001] The invention relates to the technical fields of medicines, health products and food, in particular to a composition for enhancing immunity and a preparation method thereof. Background technique [0002] Low immunity is divided into primary and secondary categories. Primary is caused by congenital hypoplasia, most of which are related to genetics and mostly occurs in children; secondary is caused by infections such as viruses, bacteria, fungi, or drugs, tumors, fatigue, insomnia, malnutrition, excessive pressure, etc. Caused by people of all ages. Most people who are weak after illness and prone to infectious diseases are secondary immunocompromised. [0003] Modern people live and work under great pressure, many people are in a sub-health state, and some people have secondary symptoms of low immunity such as dizziness, insomnia, and fatigue. It is easy to get sick, and because of frequent illnesses, the consumption of the body is aggravated, so the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P37/04A23L33/105
CPCA61K36/64A61K36/481A61K36/638A61K36/815A23L33/105A61K2236/331A61K2236/39A61K2236/51A23V2002/00A61K2300/00A23V2200/324A23V2200/30A23V2250/21A23V2300/14A23V2250/5118A23V2250/51084A23V2250/51088A23V2250/082
Inventor 肖伟丁艳王婧邓辰辰柏伟荣
Owner JIANGSU KANION PHARMA CO LTD
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