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Preparation formula of and preparation process for liposome freeze-dried powder

A preparation process and liposome technology are applied in the field of preparation formula and preparation technology of liposome freeze-dried powder, and can solve the problems of inability to form liposomes, decrease in coating rate of encapsulated substances, destruction of phospholipid bilayers, and the like, To achieve the effect of increasing toughness and improving flexibility

Active Publication Date: 2020-12-29
晟薇药业(上海)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also many difficulties in the lyophilized preparation of liposomes. For example, due to the change in the volume of ice water, the phospholipid bilayer is destroyed, resulting in the inability to form pro-liposomes after lyophilization, and the inability to form liposomes after rehydration. Body, or liposomes with larger particle size, accompanied by a sharp drop in the coating rate of the wrapped object, and serious damage to the transdermal effect

Method used

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  • Preparation formula of and preparation process for liposome freeze-dried powder
  • Preparation formula of and preparation process for liposome freeze-dried powder
  • Preparation formula of and preparation process for liposome freeze-dried powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The formula of a kind of liposome lyophilized preparation comprises: liposome, excipient, water, and described excipient selects mannitol for use; Concrete formula is made of the raw material of following percentage: mannitol 5%, liposome 50% %, the rest is water; the composition of liposomes is: 20% phospholipids, 10% cholesterol, 2% Tween 20, 5% trehalose, 7.8% retinol, 0.2% glabridin, 10% ascorbic acid, 2% tranexamic acid, 30% absolute ethanol and add water to 100%.

[0026] A preparation process of liposome freeze-dried powder, specifically comprising the following steps:

[0027] Step 1: According to the raw material percentage of the liposome formula in the liposome freeze-dried preparation, take retinol, glabridin, phospholipids, and cholesterol and dissolve them in absolute ethanol to form the ethanol phase; take trehalose, tranexamic acid, and ascorbic acid , Tween 20 is dissolved in water to form an aqueous phase;

[0028] Step 2: At 80°C, inject the ethanol...

Embodiment 2

[0033] A liposome freeze-dried formulation comprises: liposomes, excipients, water, and the excipients are trehalose; the specific formulation is made of the following percentages of raw materials: trehalose 10%, liposomes 50% %, the rest is water; wherein the liposome composition: 1% phospholipid, 0.5% cholesterol, 0.2% Tween 60, 10% trehalose, 0.2% glabridin, 2% absolute ethanol and add water to 100%.

[0034] A kind of technology of liposome freeze-dried preparation, specifically comprises the following steps:

[0035] Step 1: According to the raw material percentage of the liposome formula in the liposome freeze-dried preparation, take glabridin, phospholipids, and cholesterol and dissolve them in absolute ethanol to form the ethanol phase; take trehalose and Tween 60 and dissolve them in water to form the water phase ;

[0036] Step 2: At 80°C, inject the ethanol phase into the water phase at a rate of 0.5 liter / min, and stir while injecting, at a stirring speed of 30 rp...

Embodiment 3

[0041]A formula of liposome freeze-dried preparation comprises: liposome, excipient, water, and described excipient selects erythritol for use; Concrete formula is made of the raw material of following percentage: erythritol 15%, Liposome 50%, the rest is water; liposome composition: phospholipid 10%, cholesterol 5%, Tween 80 1%, trehalose 7.5%, oligopeptide 0.2%, resveratrol 1%, licorice Set 0.2%, vitamin E 0.5%, absolute ethanol 20% and add water to 100%.

[0042] A kind of technology of liposome freeze-dried preparation, specifically comprises the following steps:

[0043] Step 1: According to the raw material percentage of the liposome formulation in the liposome freeze-dried preparation, take resveratrol, ceramide, glabridin, phospholipid, and cholesterol and dissolve them in absolute ethanol to form the ethanol phase; take oligopeptide, seaweed Sugar and Tween 80 are dissolved in water to form the water phase;

[0044] Step 2: At 80°C, inject the ethanol phase into the...

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Abstract

The invention provides a preparation formula of liposome freeze-dried powder. The preparation formula comprises liposome, an excipient and water; the liposome freeze-dried powder is specifically prepared from the following raw materials by percentage: 50% of liposome, 5%-15% of excipient and the balance water; the liposome consists of 1%-20% of phospholipid, 0.1%-10% of cholesterol, 0.2%-2% of Tween, 5%-10% of trehalose, 0.2%-20% of active matter, 2%-30% of absolute ethyl alcohol and the balance water. The preparation formula of the liposome freeze-dried powder has the following advantages: the flexibility of the liposome is greatly improved due to the presence of the Tween, and the liposome can deform freely under the action of an external force, and the toughness is improved.

Description

technical field [0001] The invention relates to the technical field of liposomes, in particular to a preparation formula and a preparation process of liposome freeze-dried powder. Background technique [0002] Since the rapid development of natural science in the 21st century, people have discovered that more and more drugs are of great help to human health, and the field of pharmacy has also encountered various problems. Among them, the solubility, stability, and transdermal properties of drugs, It is one of the key and difficult points of current preparation technology. The carrier technology that came into being like this has become an important topic, wherein liposome technology is a typical representative of carrier technology, the advantages of liposome technology: 1, the insoluble drug is wrapped and carried, and becomes easily soluble in water Encapsulation; 2. After the unstable components are wrapped, it is well protected and the stability of the wrapped object is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K9/127A61K47/26
CPCA61K9/19A61K9/127A61K47/26
Inventor 翟春涛卢相艳李成亮
Owner 晟薇药业(上海)有限公司