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Method for extracting neohesperidin from young fruits of citrus aurantium

A technology of neohesperidin and young fruit, which is applied in the field of extracting neohesperidin, which can solve the problems of solvent residue, difficulty in product purity and color, and low product quality

Pending Publication Date: 2020-12-29
JIANGXI HAIFU BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This application mainly obtains neohesperidin through n-butanol extraction and ethanol treatment, but neohesperidin is insoluble in n-butanol, and the product yield is extremely low; n-butanol has a high boiling point, and there is serious solvent residue. Low; the purity and color of the final product are difficult to meet

Method used

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  • Method for extracting neohesperidin from young fruits of citrus aurantium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] This embodiment includes the following steps:

[0082] (1) Broken. Get 500kg dry lime young fruit, be broken into the coarse powder of particle diameter 8mm with the pulverizer of installed sieve diameter 8mm.

[0083] (2) Antioxidant extraction. Put the coarse powder into the extraction tank, add anti-oxidant protection agent, and extract 3 times with tap water. The extraction temperature is 70°C; the mixing method is stirring; the amount of antioxidant protection agent (vitamin C and ferrous sulfate, the mass ratio is 2:1): add 12.5kg (2.5% of coarse powder) for the first extraction, and add 12.5kg (2.5% of the coarse powder) for the second extraction. Add 4.0kg (0.8% of the coarse powder) for the first time, add 1.0kg (0.2% of the coarse powder) for the third time; extraction time: 2.0, 1.5, 1.0h; tap water addition: 4500L, 4000L, 3500L, the third set carry. Filter after each extraction, and the filter residue enters the next extraction. After the third extractio...

Embodiment 2

[0093] (1) Broken. Get 2000kg dried lime young fruit, be broken into the coarse powder of 6mm with the pulverizer of installed sieve diameter 8mm.

[0094] (2) Antioxidant extraction. Throw the coarse powder into a countercurrent extraction tank, add an antioxidant protection agent, and extract with tap water. Extraction temperature: 82°C; mixing method is stirring; antioxidant protection agent (vitamin C and ferrous sulfate, mass ratio: 1.5:1) addition amount: 54kg (2.7% of coarse powder); extraction time: 2.5h; tap water addition Volume: 14000L. Squeeze and filter after the extraction, and combine the continuously flowing extracts to obtain countercurrent extracts.

[0095] (3) Concentration and low temperature salting out. Pump the countercurrent extract into a vacuum decompression concentrator, control the vacuum degree of -0.085MPa, and the temperature of 63°C to concentrate under vacuum and reduce pressure to 1300L; add 170kg of Glauber's salt, stir to dissolve, and ...

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Abstract

The invention discloses a method for extracting neohesperidin from young fruits of citrus aurantium. The method comprises the following steps of (1) crushing; (2) antioxidant extraction; (3) concentration and low-temperature salting-out; (4) filtration, hot melting and clarification: filtering and collecting precipitates; (5) heat preservation desalination and molecular separation, decolorizationand concentration; (6) thermal decolorization; (7) salt-assisted fractional crystallization; (8) desalting and filtering; and (9) drying. The purity of the obtained neohesperidin can reach 99.21%, theneohesperidin is pure white, the absorbance of a 1% aqueous solution at 425 nm is smaller than or equal to 0.2%, and the ash content is smaller than or equal to 0.3%; Only water is used as a solventin the whole technological process, so that the production cost is reduced, and the production safety and the product use safety are also improved; The dried young fruits of citrus aurantium are usedas the raw material, so that the raw material is not easy to deteriorate and the content is relatively stable; expensive extraction separation equipment is not used, so that the production operation is simplified, the capital investment is reduced, and the production period is shortened; and the preparation method is simple, practical, short in period and suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting neohesperidin, in particular to a method for extracting neohesperidin from sour oranges. Background technique [0002] Neohesperidin mainly exists in some Rutaceae plants, such as sour orange, sweet orange, Citrus aurantium, Citrus aurantium, and Achilles chinensis, etc., and it still exists in Rubiaceae plant Uncaria torso, and the content in natural plants is generally low. [0003] Limes (scientific name: Citrus aurantium L.) is a small tree of the Rutaceae citrus genus, with dense branches and leaves and many thorns. It is native to the south of the southern slope of the Qinling Mountains in China, and is mainly distributed in the Yangtze River Basin and other provinces in the south of China. The young sour orange fruit is a variety of the traditional Chinese medicine Citrus aurantium, which is different from other Citrus aurantium from Rutaceae which mainly contain a large amount of hesperidin and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H17/07C07H1/08
Inventor 刘庚贵黄华学何安乐黄俊
Owner JIANGXI HAIFU BIOENG