Hemostatic and antibacterial medical dressing and preparation method thereof

A hemostatic, antibacterial, and hemostatic layer technology, which is used in dressings, pharmaceutical formulations, viscous dressings, etc.

Inactive Publication Date: 2021-01-22
世纪亿康(天津)医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on combining the hemostatic effect of silicon dioxide with the antibacterial effect of silver ions to make hemostatic antibacterial dressings

Method used

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  • Hemostatic and antibacterial medical dressing and preparation method thereof
  • Hemostatic and antibacterial medical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method of a hemostatic and antibacterial medical dressing, comprising the following steps:

[0039] a. Preparation of hemostatic layer 1

[0040] ① Take 1.7g of starch in a round bottom flask, add 170ml of distilled water, dissolve at 100°C for 3 hours, and make a starch solution with a mass concentration of 0.01g / ml;

[0041] ② Take 10ml of the above starch solution and put it in a beaker, add 30ml of absolute ethanol dropwise while stirring, then add 1.53ml of ammonia water dropwise; after reacting for 10min, add 0.357g of ethyl silicate dropwise; then stir at room temperature for 2h, centrifuge , alternately washed 3 times with absolute ethanol and distilled water, and then dried at 80°C to obtain a silica / starch composite material, that is, the hemostatic layer 1; wherein, m(starch):m(silicon dioxide)=1:1 ;

[0042] b, preparation of antibacterial layer 2

[0043] ①Under the condition of 10°C, add the non-woven fabric to the sodium hydroxide solutio...

Embodiment 2

[0050] a. Preparation of hemostatic layer 1

[0051] ① Take 1.7g of sodium carboxymethyl starch in a round bottom flask, add 170ml of distilled water, dissolve at 100°C for 3 hours, and make a sodium carboxymethyl starch solution with a mass concentration of 0.01g / ml;

[0052] ② Take 10ml of the above sodium carboxymethyl starch solution and put it in a beaker, add 30ml of absolute ethanol drop by drop while stirring, then add 1.53ml of ammonia water drop by drop; after reacting for 10min, add 0.357g of ethyl silicate drop by drop; Stir for 2 hours, centrifuge, wash 3 times alternately with absolute ethanol and distilled water, and then dry at 80°C to obtain a silicon dioxide / sodium carboxymethyl starch composite material, which is the hemostatic layer 1; wherein, m (sodium carboxymethyl starch ): m (silicon dioxide) = 1:1;

[0053] b, preparation of antibacterial layer 2

[0054] ①Under the condition of 10°C, add the non-woven fabric to the sodium hydroxide solution with a ...

Embodiment 3

[0061] The preparation method is the same as in Example 1 and Example 2, wherein, in this example, silver nitrate is used as the antibacterial agent, and sorbitol is used as the excipient.

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Abstract

The invention provides a hemostatic and antibacterial medical dressing. The dressing comprises a hemostatic layer, an antibacterial layer and a backing layer which are sequentially bonded into a wholethrough a silicone adhesive, wherein silicon dioxide microspheres are contained in the hemostatic layer to serve as a hemostatic agent; an antibacterial agent is adsorbed in the antibacterial layer;and silver ions are contained in the antibacterial agent. The hemostatic and antibacterial medical dressing is prepared from the hemostatic layer, the antibacterial layer and the backing layer; the hemostatic layer uses the silicon dioxide microspheres as the hemostatic agent; when the dressing acts on the surface of a wound, a large amount of water can be rapidly adsorbed from blood to promote platelet coagulation, so that the thrombin activation time can be remarkably shortened; and meanwhile, the silver ions are used as the antibacterial agent in the antibacterial layer, the antibacterial effect is taken, and the antibacterial effect on the wound surface is achieved, so that the wound surface is repaired as soon as possible.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a hemostatic and antibacterial medical dressing and a preparation method thereof. Background technique [0002] Silver ion antibacterial has been used to prevent and treat burn wound infection for more than half a century. In recent years, new silver-containing dressings are also developing rapidly, but silver-containing dressings can only be used as an auxiliary means of anti-infection. Silicon dioxide is used as a hemostatic agent, and there are many reports on its clinical use. Chinese patent 201010248217 discloses a method for preparing an antibacterial biological dressing containing nano-silver / nanometer silicon dioxide, which mainly describes the co-production of silver-loaded silicon dioxide, polyvinyl alcohol and chitosan in the polyvinyl acetalization reaction. The mixture is cured to become a dressing. Chinese patent 201410061101 discloses a preparation method of nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/46A61F13/00A61F13/02
CPCA61L15/18A61L15/46A61F13/00063A61F13/00987A61F13/02A61L2300/104A61L2300/404A61L2400/04A61F13/01029A61F13/01008A61F13/01034
Inventor 胡姣
Owner 世纪亿康(天津)医疗科技发展有限公司
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