31results about How to "Meet actual clinical needs" patented technology

The invention provides an X-ray image acquisition method and device. The acquisition method includes the steps that an initial rack parameter and the overlapping region of every two adjacent frames are set according to a pre-exposure region, and an initial exposure frame number for image splicing is calculated; the initial exposure frame number is adjusted so that an actual exposure frame number can be obtained, an actual rack parameter is determined according to the actual exposure frame number so that the actual exposure region cannot be larger than the pre-exposure region, and the absolute value of the difference value between the actual exposure frame number and the initial exposure frame number is smaller than one; on the basis of the actual exposure frame number and the actual rack parameter, the corresponding detector position and a bulb tube rotating angle are calculated when each frame is acquired; exposure is performed according to the actual rack parameter and the corresponding detector position and the bulb tube rotating angle which are calculated when each frame is acquired, and therefore an image to be spliced is obtained. By the adoption of the method and device, it is avoided that a detected object receives too much doses of radiation in the shooting process.

The invention discloses a metal vascular clamp capable of being degraded and absorbed directionally and a manufacturing method thereof. The metal vascular clamp comprises an upper arm, a lower arm and a tail O-shaped structure, all of which are used for closing the blood vessel. A V-shaped structure is formed by the upper arm, the lower arm and the tail O-shaped structure before closing. The end of the upper arm and the end of the lower arm are provided with self-locking structures matched with each other. When the metal vascular clamp is used, a gap between the upper arm and the lower arm of the V-shaped structure is placed on the blood vessel needing to be closed, and the upper arm and the lower arm are extruded to enable the included angle between the upper arm and the lower arm to gradually become smaller until the self-locking structure of the upper arm and the self-locking structure of the lower arm are locked and closed. The outer side and the inner side of the upper arm and the outer side and the inner side of the lower arm are provided with different microstructures and electric potential differences, the grains on the outer sides are larger than the grains on the inner sides, the electric potential differences on the outer sides are lower than the electric potential differences on the inner sides, and directional degrading from the outer side of the blood to the inner side of the blood is achieved after the vascular clamp is closed. According to the metal vascular clamp, the electric potential differences are changed by changing the tissue structure differences of different positions of the vascular clamp in a directional mode, and orientation degrading in different degrading sequences is achieved.

The embodiment of the invention discloses an image iterative reconstruction method, a device, a device and a storage medium. The method comprises the following steps of: acquiring original projectiondata of a target object; Determining a first initial value image and a second initial value image based on the original projection data, the pixel point range of the first initial value image including the pixel point range of the second initial value image; Performing a first step of iterating the original projection data and the first initial value image to determine a first iterative image, anddetermining a second iterative projection data according to the original projection data and the first iterative image; The second iterative projection data and the second initial value image are iterated in a second step to obtain a reconstructed image. The technical proposal of the embodiment of the invention can directly iteratively reconstruct a local FOV image, thereby satisfying reconstruction robustness and accelerating reconstruction speed.

The invention discloses a mammary gland imaging device. The device comprises a compressing plate used for compressing the mammary gland, and a control processing part used for controlling the compressing plate to compress the mammary gland, and further comprises a pain perception part used for perceiving physiologic pain information of an examinee and sending the pain information to the control processing part, wherein the control processing part is further used for controlling the compressing plate to compress the mammary gland according to the physiologic pain information. According to the mammary gland imaging device, the compressing operation of the mammary gland compressing plate is controlled by detecting the pain information of the examinee; the compression is continuously applied when a compressing upper limit value is not exceeded, and the pain information of the examinee is detected; and once the examinee is discovered to feel uncomfortable or painful, the situation can be fed back to the control processing part through the pain perception part, and the compression on the mammary gland is stopped, so that the injury caused by the fact that the examinee feels painful or the mammary gland is excessively oppressed can be avoided and a relatively user-friendly and intelligent control effect is achieved.

The present invention discloses a bone repair material constructed by 3D printing, a preparation method and an application thereof. The bone repair material is composed of an inner core structure comprising an inner layer portion and a peripheral portion, an outer layer structure, and an anti-micro-organism spraying coating layer. The 3D printed bone repair material realizes combination of a degradable and bone growth-inducing material and engineering plastics with excellent mechanical properties, and ensures strength of the bone repair material by optimizing the structure. An outermost layeris sprayed and coated with self-made mixed powder of hydroxyapatite containing trace elements and silver, which promotes bone healing and also imparts certain anti-micro-organism properties. In addition, shaping of the bone repair material is realized by means of 3D printing with double spraying nozzles, and the preparation method saves complicated processes of traditional processing processes, also improves accuracy, achieves personal molding and enables the bone repair material to be more in line with clinical requirements.

The embodiment of the invention discloses computing equipment for the radiation dose, devices and a storage medium. The equipment comprises one or more processors, and a storage for storing one or more programs; when one or more programs are executed by one or more processors, one or more processors obtain information corresponding to a target object, determine first dose distribution corresponding to the target object according to the Monte Cario algorithm and the information corresponding to the target object, adopt the first dose distribution and the information corresponding to the targetobject as the input of a preset neural network model, and determine second dose distribution corresponding to the target object according to the output result of the preset neural network model, wherein the precision of the second dose distribution is higher than that of the first dose distribution. According to the technical scheme, the high computing speed and the high computing precision can beensured, and the clinic requirement is met.

The invention discloses a patient-level tumor intelligent diagnosis method based on full-view digital slicing; and the method comprises the following steps: obtaining a plurality of case databases ofa certain disease, and enabling each case database to name a folder after the ID of each patient, storing a plurality of full-view digital sections of biopsy tissue sections of all cases to be diagnosed and corresponding diagnosis results in each case database; extracting a digital slice with the minimum size at the bottom of the picture file stack of each full-view digital slice as a color imageof the full-view digital slice, and zooming the color image to obtain a color thumbnail; merging all the color thumbnails of a certain case into a full-view digital slice multichannel thumbnail according to channels; constructing a deep learning algorithm model; and loading all full-view digital slices of a certain case of the current disease, and outputting an intelligent diagnosis result. According to the invention, effective utilization of the full-view digital slice requiring large storage capacity is realized.

The invention provides an extraction method of a skin area in a medical image. The extraction method comprises the following steps of: importing the medical image of a patient, obtaining a sequence slice image; carrying out binary processing on the sequence slice image; carrying out high gray value point searching on the sequence binary slice image, and when a high gray value point is searched, judging whether the high gray value point is and isolated point, if yes, continuing searching, if not, carrying out contour tracking with the high gray value point serving as a start point, obtaining the number of contour point sets, then judging whether the number of contour point sets is larger than a preset threshold, if yes, indicating that skin area contour extraction is successful, if not, continuing searching for the next high gray value point until the number of obtained contour point sets is larger than the preset threshold, and obtaining a sequence skin contour image; carrying out area filling on the sequence skin contour image; and carrying out face extraction on the sequence skin contour image, obtaining three-dimensional face data of the skin area, and completing the extraction of the skin area. The method is simple to realize, high in speed and capable of meeting a plurality of clinic demands.

The invention relates to a method for performing surface modification on titanium-based implant and a titanium-based implant surface composite coating. The titanium-based implant surface composite coating comprises an inner layer, a middle layer and an outer layer which are sequentially formed on the base body of the titanium-based implant; the inner layer is formed inwards from the surface of the titanium-based implant in the thickness direction, an M metal material exists in the form of an M simple substance and an M oxide, and M is calcium and / or strontium; an M metal material exists in the middle layer in the form of a simple substance of M and an oxide of M, and an N metal material exists in the form of an oxide of N, and N is at least one of magnesium, calcium, zinc, sodium and potassium; the outer layer comprises an oxide of N; the degradation time of the N oxide in the outer layer in the physiological environment is controlled by regulating and controlling the thickness of the outer layer film.

The invention relates to a method for carrying out surface modification on a polyether-ether-ketone material and the modified polyether-ether-ketone material. Based on the electron beam evaporation technology, biological ceramic with silicon is adopted as an evaporation target, silicon is evaporated and deposited on the surface of the polyether-ether-ketone material, and a modified layer with silicon is obtained. Based on the electron beam evaporation technology, silicon is introduced into the surface of the polyether-ether-ketone material, the method is simple and feasible, the modification effect is excellent, the content of silicon is controllable, and the surface biocompatibility and frame integration of the polyether-ether-ketone material can be greatly improved.

The invention discloses a primer set for detecting mutation of an ESR1 gene, a reagent, a kit and a method thereof, which relate to the field of biological medical science. The primer set for detecting the mutation of the ESR1 gene disclosed in the present invention includes any one or more of the following primer combinations: a primer combination 1, a primer combination 2, and a primer combination 3. The primer set can accurately detect 11 mutations of the ESR1 gene, and has the advantages of high sensitivity and good specificity, and can accurately detect the mutation of 0.1% in a total of20 ng DNA samples. The primer set can be applied to the detection of tissue samples and plasma samples, and can flexibly adapt to the needs of clinical testing. The detection method is simple in operation and the detection results are clear and easy to analyze.

The invention discloses a mechanical arm force feedback system and method, a control method and a control terminal. The system comprises a force detection fixing module which is used for collecting the force application data of an operator, a control module, a force feedback state adjusting module and a mechanical arm, wherein the control module is used for judging the force application state of the operator according to the received force application data, and the force application state comprises an active force application state and a non-active force application state; the force feedback state adjusting module is used for adjusting the working state of the force feedback state adjusting module according to the force application state; and the mechanical arm is used for converting into a mechanical arm state adapting to the working state according to the working state of the force feedback state adjusting module. Real-time movement and hovering of the mechanical arm can be achieved through algorithm control and according to the force application condition of an operator, and the actual clinical requirement that a surgeon needs to relax and rest upper limbs under the long-time operation condition is met. The mechanical arm can be used in cooperation with a surgical robot and can also be used as an independent surgical instrument, and the application range is enlarged.

The invention relates to a method of surface-modifying a polyether ether ketone material, which includes a step of performing zinc ion implantation or zinc / oxygen binary ion implantation through the surface of the polyether ether ketone material through a plasma immersed ion implantation technology to obtain the modified polyether ether ketone material.

The invention discloses a test strip for combined detection of CRP and SAA, a kit and a preparation method, and relates to the technical field of in-vitro diagnostic reagents. The test strip can broaden the upper and lower limits of CRP and SAA combined detection, can detect low-concentration and high-concentration samples at the same time, and can meet the actual clinical requirements. In addition, the test strip has relatively high CRP and SAA detection sensitivity, and is high in precision and short in detection time. When the antigen concentration is low, fluorescent microspheres with the particle size of 330 + / -25 nm play a main role, and the low-concentration antigen can be stably detected. When the concentration of the antigen is high, fluorescent microspheres with the particle size of 150nm + / -25nm play a main role, so that the antigen in a to-be-detected sample can be detected on the premise of not dilution again, the discrimination of a high-concentration region is expanded, and the linearity is widened.

Provided is an X-ray image acquisition method and device. The X-ray image acquisition method comprises the steps that according to initial rack parameters set in a pre-exposure zone and overlapped zones of two adjacent frames of images, initial exposure frame number for image splicing is calculated; the initial exposure frame number is adjusted to obtain actual exposure frame number, actual rack parameters are determined according to the actual exposure frame number so that an actual exposure zone is not greater than the pre-exposure zone, and an absolute value of the difference of the actual exposure frame number and the initial exposure frame number is smaller than 1; based on the actual exposure frame number and the actual rack parameters, corresponding detector positions and bulb tube rotation angles during acquisition of the frames of images are calculated; exposure is performed according to the actual rack parameters and the corresponding detector positions and the bulb tube rotation angles during acquisition of the frames of images, and images to be spliced are obtained. By adopting the method and device, an examined object can be effectively prevented from receiving excessive radiation dosage in the photography process.

The invention belongs to the field of radiotherapy dose calculation, which relates to a dose calculation method for non-uniform grid distribution simulation linear accelerator treatment plan and a device thereof, and a storage medium. The method comprises the following steps: setting non-uniform grid parameters and initial flux values of corresponding grids; calculating the contribution of each grid to the total dose distribution, and superposing to obtain the dose of the whole radiation field in the selected die body; comparing the difference between the real dose and the dose calculation; ifthe difference is within a preset calculation precision range, receiving a current grid segmentation parameter and a flux value for dose calculation of a patient treatment plan; and if the differenceexceeds the preset calculation precision range, finely adjusting the separation of the grid in the y direction and the flux value corresponding to each grid, and then carrying out dose calculation until the calculation result meets the preset precision. According to the method, the radiation dose is calculated through the non-uniform two-dimensional flux grid, the resolution of the grid does notneed to be adjusted, the dose value of each grid can be directly calculated according to mechanical parameters, and the number of the grids is controllable.

The invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a pyrazole alcohol-pyridazinone coupling compound and a pharmaceutical composition thereof and application of the pyrazole alcohol-pyridazinone coupling compound in medicine. The pyrazole alcohol-pyridazinone coupled compound has dual action mechanisms of resisting platelet aggregation and protecting nerve cells, and is applied to preparation of medicines for preventing or treating cerebral apoplexy, cardiovascular and cerebrovascular diseases, senile dementia and complications thereof caused by thrombus and excessive free radicals.

The invention discloses a bone repair material constructed by 3D printing, a preparation method and application thereof. The bone repair material is composed of an inner core structure including an inner layer part and a peripheral part, an outer layer structure and an antibacterial spray layer. The 3D printed bone repair material of the present invention combines degradable materials with the ability to induce bone growth with engineering plastics with excellent mechanical properties by optimizing the structure, ensuring the strength of the bone repair material. The outermost layer is sprayed with The self-made hydroxyapatite and silver mixed powder of trace elements can promote bone healing and endow the material with certain antibacterial properties; in addition, the molding of the bone repair material of the present invention is realized by double-nozzle 3D printing, which omits the traditional The complicated process of processing technology improves the precision and realizes individual shaping, which is more in line with clinical needs.

The embodiment of the invention discloses a radiation dose calculation device, device and storage medium. The device includes: one or more processors; a memory for storing one or more programs; when the one or more programs are executed by the one or more processors, the one or more processors perform the following operations: obtain the target The information corresponding to the object; according to the Monte Carlo algorithm and the information corresponding to the target object, determine the first dose distribution corresponding to the target object; use the first dose distribution and the information corresponding to the target object as the input of the preset neural network model, according to the preset The output result of the neural network model determines the second dose distribution corresponding to the target object; wherein, the accuracy of the second dose distribution is higher than the accuracy of the first dose distribution. Through the technical solutions of the embodiments of the present invention, faster calculation speed and higher calculation accuracy can be ensured to meet clinical needs.

A method, device and medical imaging system for removing artifacts from an image. The method for removing artifacts from an image includes: obtaining a system matrix of the imaging system. The system matrix gives the i-th ray passing through j voxels. Finally, the blur factor corresponding to the i-th pixel imaged in the imaging unit and the pixels in the predetermined neighborhood centered on the i-th pixel is used; the system matrix is ​​used for the iterative reconstruction method to reconstruct to remove the blur in the image artifacts. The image quality reconstructed by applying the inventive technical solution is better, meets the actual clinical needs, and avoids missed diagnosis or misdiagnosis.

The invention discloses a method, device and CBCT system for removing motion blur in a CBCT system projection image. The method for removing motion blur in a CBCT system projection image includes determining the area N occupied by a voxel in the projection image, The size of the area N is related to the angular velocity W of the gantry movement in the CBCT system, the exposure time T of the CBCT system, the pixel size L of the imaging unit, and the distance D from the rotation center of the gantry to the plane of the imaging unit; in a frame of not less than The first projection image is collected at a rate, and each INT (FR×T) first projection image is synthesized to generate a projection image with motion blur removed. The projection image synthesized by the method of the present invention eliminates motion blur caused by the movement of the detector, and can significantly improve the spatial resolution and signal-to-noise ratio of the projection image.

The invention discloses a method and a device for removing motion blur from a projected image of a CBCT (Cone Beam Computerized Tomography) system and the CBCT system. The method for removing the motion blur from the projected image of the CBCT system comprises the steps: determining an area N occupied by tissue in the projected image, wherein the size of the area N is related to an angular speed W of motion of a rack of the CBCT system, exposure time T of the CBCT system, a pixel size L of an imaging unit and a distance D from the center of rotation of the rack to a plane of the imaging unit; acquiring a first projected image at a frame rate which is not smaller than a formula shown in the description, synthesizing every INT (FR*T) first projected images so as to generate the motion blur removed projected image. By adopting the method disclosed by the invention, the motion blur caused by detector motion is removed from the synthesized projected image, and the spatial resolution and signal-to-noise ratio of the projected image can be remarkably increased.

The embodiment of the present application discloses a hemodynamic index determination method, device, device, and storage medium, wherein the method includes: responding to a hemodynamic index prediction request, determining the hemodynamic index prediction request The point cloud coordinate data set corresponding to the medical image in the medical image; the first space coordinate transformation is performed on each point cloud coordinate data in the point cloud coordinate data set to obtain the first point cloud coordinate data after space coordinate transformation; The point cloud coordinate data is subjected to first high-dimensional space mapping processing to obtain second point cloud coordinate data with a first preset dimension; wherein, the first preset dimension is greater than the initial dimension of the first point cloud coordinate data ; Splicing the second point cloud coordinate data and the first point cloud coordinate data to form a splicing vector; performing dimension reduction processing on the splicing vector to obtain a hemodynamic index.

The mechanical arm force feedback system, method, control method, and control terminal of the present invention include: a force detection and fixing module for collecting force application data of the operator; a control module for judging the force application data according to the received force application data. The force application state of the operator, wherein the force application state includes: an active force application state and a non-active force application state; a force feedback state adjustment module, which is used to adjust its own working state according to the force application state; the mechanical arm, It is used to adjust the working state of the module according to the force feedback state, and transform it into a state of the mechanical arm adapted to the working state. The invention can realize the real-time movement and hovering of the mechanical arm through algorithm control and according to the force applied by the operator, which meets the actual clinical needs of the surgeon who needs to relax and rest the upper limbs under long-term operation conditions. The present invention can be used not only in conjunction with a surgical robot, but also as an independent surgical instrument, which expands its scope of application.

A metal vascular clamp capable of being directionally degraded and absorbed and a manufacturing method therefor. The vascular clamp comprises an upper arm (2), a lower arm (3) and a tail O-shaped structure (4) all used for closing a blood vessel (1). A V-shaped structure is formed by the upper arm (2), the lower arm (3) and the tail O-shaped structure (4) before closing. The end of the upper arm (2) and the end of the lower arm (3) are provided with self-locking structures (5, 6) matched with each other. When the metal vascular clamp is used, the blood vessel needing to be closed is placed in a gap between the upper arm (2) and the lower arm (3) of the V-shaped structure, and the upper arm (2) and the lower arm (3) are squeezed to enable the included angle therebetween to be gradually decreased until the self-locking structures (5, 6) of the upper arm and the lower arm are mutually locked and closed. The outer side and the inner side of the upper arm (2) and the outer side and the inner side of the lower arm (3) are provide with different microstructures and electric potential differences, the grains on the outer sides are dimensionally larger than the grains on the inner sides and the electric potential differences on the outer sides are lower than the electric potential differences on the inner sides, so that directional degradation from the outer side to the inner side is achieved after the vascular clamp is closed. Through the change of the tissue structure differences of different parts of the material of the vascular clamp in a directional way, the electric potential differences thereof can be changed, and thus the directional degradation in different orders of degradation is achieved.

The invention discloses a gear-adjustable orthodontic traction buckle device which solves the problem that in the prior art, an elastic rubber ring and a tongue side buckle are used for applying force to target teeth, but after the tongue side buckle is bonded to the target teeth, the rubber ring stimulates gingiva to cause mucosa trauma due to insufficient length of the tongue side buckle. The gear-adjustable orthodontic traction buckle device has the beneficial effects that different bonding positions and stress application directions can be selected according to ideal final positions of target teeth, and the specific scheme is as follows: the gear-adjustable orthodontic traction buckle device comprises a cap buckle, a gourd-shaped connecting column and a base, the cap buckle, the gourd-shaped connecting column and the base are sequentially arranged along the axial direction, and a most convex part is arranged on the gourd-shaped connecting column.

The invention discloses a universal prefabricated bone ring for oral implant which belongs to the field of medical instruments and is suitable for implant cases with bone increment. The bone ring is in a ring shape, wherein a guide hole is arranged at the center of the bone ring, and the outer diameter of the bone ring is in the range of 4.5-8.5 mm, guide hole diameter is in the range of 1-3.4 mm,the height range is 2-7 mm. Bone rings are made from xenogeneic bone, allogeneic bone, or synthetic materials. The implant was implanted into the implant socket through the through-hole, and the bonering was fixed in the implant bed, and the implant and bone incremental operation are completed simultaneously. The bone ring adopts a guide hole design, and the step-by-step reaming hole can be adapted to different planting systems and models; The height, outer diameter and thickness of the bone ring can be selected flexibly, which ensures that the prefabricated bone ring has stronger adaptability and versatility.

The invention relates to a method for surface modification of a titanium-based implant and a composite coating on the surface of the titanium-based implant. The composite coating on the surface of the titanium-based implant comprises an internal layer, intermediate layer and outer layer; the inner layer is formed inward from the surface of the titanium-based implant along the thickness direction, and M metal material exists in the form of M element and M oxide, and M is calcium and / or strontium; M metal material exists in the intermediate layer in the form of M element and M oxide, and N metal material exists in the form of N oxide, and N is magnesium, calcium, zinc, sodium At least one of potassium and potassium; the outer layer includes N oxides; by adjusting the thickness of the outer layer film, the degradation time of the N oxides in the outer layer under physiological environment is controlled.