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A method for surface modification of titanium-based implant and composite coating on the surface of titanium-based implant

A surface composite and implant technology, applied in coating, metal material coating process, drug delivery, etc., can solve the problems of easy bacterial infection and implant loosening, and achieve inhibition of bacterial proliferation and good osseointegration , the effect of improving biocompatibility

Active Publication Date: 2022-08-09
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problem that the antibacterial and osteogenic properties of titanium-based implants currently used in clinical practice are prone to bacterial infection in the early stage of implantation and loosening of implants in the later stage of implantation, the purpose of the present invention is to provide a titanium surface (titanium-based implant) Implant surface) modification method to meet the requirements of medical titanium implant materials with better antibacterial performance at the initial stage and better osteogenesis performance at the later stage

Method used

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  • A method for surface modification of titanium-based implant and composite coating on the surface of titanium-based implant
  • A method for surface modification of titanium-based implant and composite coating on the surface of titanium-based implant
  • A method for surface modification of titanium-based implant and composite coating on the surface of titanium-based implant

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Experimental program
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Effect test

Embodiment 1

[0076] (1) Clean the 10mm×10mm×1mm pure titanium metal sheet with acetone, absolute ethanol and deionized water ultrasonically in turn, for 10 minutes each time, and then carry out ultrasonic pickling treatment. The pickling solution is made of hydrofluoric acid, Nitric acid and ultrapure water were mixed in a volume ratio of 1:5:4; then deionized water was ultrasonically cleaned to obtain a clean and uniform surface, that is, acid-washed titanium surface (represented by Ti). The resulting surface has a rough microstructure, and protrusions can be found on the surface under high magnification (see figure 1 shown).

[0077] (2) The plasma immersion ion implantation technology is used, and a metal calcium cathode is selected to perform calcium ion implantation on the titanium surface obtained by cleaning, and a Ca-Ti layer is constructed on the titanium surface. The specific process conditions and parameters are shown in Table 2. The surface morphology of the modified titanium...

Embodiment 2

[0087]The surface ion release amount of the titanium material obtained by the modification treatment in the above Example 1 in normal saline was analyzed and detected. Put the sample into a 15mL centrifuge tube, add 10mL normal saline, and soak it at 37°C for 1, 4, 7, 14, 21, 35 and 49 days. The extracts were collected at each time point and re-added with 10 mL of fresh normal saline. The contents of Mg and Ca ions in the collected extracts were tested by inductively coupled plasma atomic emission spectrometer (ICP-AES, Varian Liberty 150, USA).

[0088] Figure 5 It is the Mg ion (Mg ion ( Figure 5 5a) and Ca ions ( Figure 5 5b) release results. It can be seen from 5a that after the 14th day of immersion, the Mg ion release of the MgO-Ti and MgO@Ca-Ti samples was significantly reduced, indicating that the MgO film on the surface of the composite modified titanium samples could exist in normal saline for about 14 days; The release rate of Mg ions was faster in 1, 4 and ...

Embodiment 3

[0090] The alkaline strength of the local microenvironment on the surface of the titanium material obtained by the modification treatment in the above-mentioned Example 1 in the normal saline was evaluated. The samples were placed in a 15 mL centrifuge tube, 5 mL of physiological saline was added, and soaked at 37°C for 24 hours. Using a pH meter (FE20-FiveEasy TM , METTLER TOLEDO) to measure the pH of saline at each time point.

[0091] The pH values ​​of normal saline after soaking Ti, Ca-Ti, MgO-Ti and MgO@Ca-Ti samples for 24 hours are as follows: Image 6 shown. The pH values ​​of the normal saline in the Ti and Ca-Ti sample groups are similar, while the pH values ​​of the normal saline in the MgO-Ti and MgO@Ca-Ti sample groups are all over 10, which is significantly larger than that in the Ti sample group, indicating that the surface of the MgO film can rapidly form alkaline Microenvironment.

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Abstract

The invention relates to a method for surface modification of a titanium-based implant and a composite coating on the surface of the titanium-based implant. The composite coating on the surface of the titanium-based implant comprises an internal layer, intermediate layer and outer layer; the inner layer is formed inward from the surface of the titanium-based implant along the thickness direction, and M metal material exists in the form of M element and M oxide, and M is calcium and / or strontium; M metal material exists in the intermediate layer in the form of M element and M oxide, and N metal material exists in the form of N oxide, and N is magnesium, calcium, zinc, sodium At least one of potassium and potassium; the outer layer includes N oxides; by adjusting the thickness of the outer layer film, the degradation time of the N oxides in the outer layer under physiological environment is controlled.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and particularly relates to a method for surface modification of a titanium-based orthopaedic implant and a composite coating on the surface of the titanium-based implant. Background technique [0002] The market for hard tissue implants is huge due to the increasing number of patients with tooth defects, fractures, osteoporosis, and bone tumors. Titanium and its alloys have become the preferred materials for hard tissue replacements and restorations due to their excellent biocompatibility, corrosion resistance, and good mechanical properties. [0003] But so far, implant surgery failures still occur frequently. Long-term clinical studies have found that the critical issues that limit the success rate and service life of titanium-based implants are as follows (Progressin Materials Science, 2009, 54: 397-425 ): On the one hand, the surface of titanium-based implants has no antibacterial...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/54A61L27/58A61L27/06C23C14/48C23C14/35C23C14/08
CPCA61L27/54A61L27/58A61L27/30A61L27/06C23C14/48C23C14/35C23C14/082A61L2400/18A61L2420/08A61L2420/02A61L2430/02A61L2300/102A61L2300/404A61L2300/412
Inventor 刘宣勇马小涵谭继
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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