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Method for performing surface modification on titanium-based implant and titanium-based implant surface composite coating

A surface composite and implant technology, applied in coating, metal material coating process, drug delivery, etc., can solve the problems of easy bacterial infection and implant loosening, and achieve inhibition of bacterial proliferation and good osseointegration , promote the effect of adhesion

Active Publication Date: 2021-06-25
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problem that the antibacterial and osteogenic properties of titanium-based implants currently used in clinical practice are prone to bacterial infection in the early stage of implantation and loosening of implants in the later stage of implantation, the purpose of the present invention is to provide a titanium surface (titanium-based implant) Implant surface) modification method to meet the requirements of medical titanium implant materials with better antibacterial performance at the initial stage and better osteogenesis performance at the later stage

Method used

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  • Method for performing surface modification on titanium-based implant and titanium-based implant surface composite coating
  • Method for performing surface modification on titanium-based implant and titanium-based implant surface composite coating
  • Method for performing surface modification on titanium-based implant and titanium-based implant surface composite coating

Examples

Experimental program
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Effect test

Embodiment 1

[0076] (1) The pure titanium metal sheet of 10mm×10mm×1mm was ultrasonically cleaned with acetone, absolute ethanol and deionized water in sequence, each time for 10 minutes, followed by ultrasonic pickling, and the pickling liquid was made of hydrofluoric acid, Nitric acid and ultrapure water are mixed at a volume ratio of 1:5:4; then deionized water is ultrasonically cleaned to obtain a clean and uniform surface, that is, an acid-washed titanium surface (indicated by Ti). The obtained surface is a rough microstructure, and it can be found that there are protrusions on the surface under a high-magnification microscope (see figure 1 shown).

[0077] (2) Using the plasma immersion ion implantation technique, selecting a metal calcium cathode, performing calcium ion implantation on the cleaned titanium surface, and constructing a Ca-Ti layer on the titanium surface. The specific process conditions and parameters are shown in Table 2. The morphology of the surface of the modifi...

Embodiment 2

[0087]The surface ion release amount of the titanium material obtained through the modification treatment of the above-mentioned Example 1 in physiological saline was analyzed and detected. Put the sample into a 15mL centrifuge tube, add 10mL of physiological saline, and soak at 37°C for 1, 4, 7, 14, 21, 35 and 49 days. The extract was collected at each time point, and 10 mL of fresh saline was added again. The contents of Mg and Ca ions in the collected leachate were tested by inductively coupled plasma atomic emission spectrometer (ICP-AES, Varian Liberty 150, USA).

[0088] Figure 5 It is the Mg ion ( Figure 5 5a) and Ca ions ( Figure 5 5b) release results. It can be seen from 5a that after soaking for 14 days, the release of Mg ions from the MgO-Ti and MgO@Ca-Ti samples was significantly reduced, indicating that the MgO film on the surface of the composite modified titanium sample can exist in normal saline for about 14 days; In 1, 4 and 7 days, the release rate of...

Embodiment 3

[0090] The alkalinity of the local microenvironment on the surface of the titanium material obtained through the modification treatment of the above-mentioned Example 1 in physiological saline was evaluated. Place the sample in a 15mL centrifuge tube, add 5mL of normal saline, and soak at 37°C for 24 hours. Using a pH meter (FE20-FiveEasy TM , METTLER TOLEDO) to measure the pH value of saline at each time point.

[0091] The pH values ​​of normal saline after soaking Ti, Ca-Ti, MgO-Ti and MgO@Ca-Ti samples for 24 hours are as follows Figure 6 shown. The pH values ​​of the normal saline in the Ti and Ca-Ti sample groups are similar, while the pH values ​​of the normal saline in the MgO-Ti and MgO@Ca-Ti sample groups are both over 10, which is significantly higher than that in the Ti sample group, indicating that the surface of the MgO film can quickly form an alkaline Microenvironment.

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Abstract

The invention relates to a method for performing surface modification on titanium-based implant and a titanium-based implant surface composite coating. The titanium-based implant surface composite coating comprises an inner layer, a middle layer and an outer layer which are sequentially formed on the base body of the titanium-based implant; the inner layer is formed inwards from the surface of the titanium-based implant in the thickness direction, an M metal material exists in the form of an M simple substance and an M oxide, and M is calcium and / or strontium; an M metal material exists in the middle layer in the form of a simple substance of M and an oxide of M, and an N metal material exists in the form of an oxide of N, and N is at least one of magnesium, calcium, zinc, sodium and potassium; the outer layer comprises an oxide of N; the degradation time of the N oxide in the outer layer in the physiological environment is controlled by regulating and controlling the thickness of the outer layer film.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a method for modifying the surface of a titanium-based orthopedic implant and a composite coating on the surface of the titanium-based implant. Background technique [0002] Due to the increasing number of patients with tooth loss, fractures, osteoporosis, and bone tumors, the market for hard tissue implants is in great demand. Titanium and its alloys have become the materials of choice for hard tissue substitutes and restorations due to their excellent biocompatibility, corrosion resistance, and good mechanical properties. [0003] But so far, the phenomenon of implant surgery failure still often occurs. Long-term clinical studies have found that the key issues that restrict the success rate and service life of titanium-based implants are as follows (Progressin Materials Science, 2009, 54:397-425 ): On the one hand, the surface of titanium-based implants h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/54A61L27/58A61L27/06C23C14/48C23C14/35C23C14/08
CPCA61L27/54A61L27/58A61L27/30A61L27/06C23C14/48C23C14/35C23C14/082A61L2400/18A61L2420/08A61L2420/02A61L2430/02A61L2300/102A61L2300/404A61L2300/412
Inventor 刘宣勇马小涵谭继
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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