Green colistin extraction method

A colistin and green technology, applied in the field of medicine, can solve the problems of high cost of sewage treatment, high environmental pollution, long process, etc., and achieve the effects of low cost of sewage treatment, short process and less waste liquid
CN112250736AInactive Publication Date: 2021-01-22HEBEI SHENGXUE DACHENG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEBEI SHENGXUE DACHENG PHARMA
Publication Date
2021-01-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a green colistin extraction method. The key is that the method comprises the following steps of (a) heating colistin fermentation liquor; (b) adjusting the pH value to 1.5-2.0 by using an acidic substance, and then performing stirring for 30 minutes; (c) adjusting the pH value to 9.5-11.5 by using a divalent alkaline substance, and then performing stirring for 30 minutes; (d) performing plate frame filtration, collecting solids, neutralizing a filtrate, and taking the neutralized filtrate as water for fermentation of the next batch of colistin; (e) dissolving the solids obtained by the plate frame filtration with an acidic solution; (f) adding activated carbon and a purifying agent into an acidic dissolving solution, and performing plate frame filtration to obtain a colistin concentrated solution; (g) carrying out resin desalination and ultrafiltration on the concentrated solution to remove endotoxin, and finally carrying out spray drying to obtain a finished product; and (h) applying a trapped fluid of an ultrafiltration membrane to the next batch of colistin fermentation liquor for dilution. The extraction method has the advantages of short process, low sewage treatment cost and less environmental pollution.
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Description

Technical field

[0001] The invention belongs to the technical field of medicine, and specifically relates to a method for extracting colistin in a green color.Background technique

[0002] At present, the industry mainly uses the ion exchange resin method to extract colistin. The pentavalent colistin cation is adsorbed through the macroporous resin, and then the colistin is eluted from the resin with sulfuric acid. Further, metal ions such as calcium and magnesium in the material liquid are removed by desalting resin, and then decolorizing agent is used for decolorizing treatment, and finally spray-dried to obtain finished powder. Although the quality of the product obtained by this method is high and stable, the adsorption effluent of the macroporous resin contains a large amount of impurities and has a large volume. Finally, it is discharged as wastewater, which puts huge pressure on cost and environmental protection.

[0003] Other separation processes of colistin mainly include solvent ex...

Claims

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