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Staining solution for ocular surface staining and preparation method thereof

A technology of dyeing solution and ocular surface, which is applied in the field of dyeing solution for ocular surface dyeing and its preparation, which can solve the problems of lightening of color, cumbersome operation, and decrease of dye content, and achieve the effect of stable solution, simple operation and convenient operation

Pending Publication Date: 2021-02-09
TIANJIN JINGMING NEW TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent application number is 201420082309.5 and the patent application number is 201520328064.4. One end of the test paper handle is clamped with adsorption sodium fluorescein test paper, and the other end is clamped with adsorption Lissamine green test paper. When using it, first use one end of the fluorescein sodium test paper to stain the cornea, and then Then use the Lissamine Green test paper at the other end to stain the cornea and conjunctiva. The disadvantage of this technique is that it is cumbersome to operate, and the simultaneous staining of the cornea and conjunctiva cannot be completed at one time, and it is inconvenient for the examiner to operate.
The patent application number is 200920252329.1, which is a paper handle. The front end of the paper handle is clamped and bonded with a test paper sheet adsorbed with a mixed dye of sodium fluorescein and Lissamine green. This test paper combines sodium fluorescein and Lissamine green Although this technique can simultaneously stain the cornea and conjunctiva at one time, the mixing system is unstable due to the mixture of two dyes. As time goes by, the dye content on the test strip decreases. The color becomes lighter, resulting in inaccurate test results

Method used

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  • Staining solution for ocular surface staining and preparation method thereof
  • Staining solution for ocular surface staining and preparation method thereof
  • Staining solution for ocular surface staining and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Solution 1: Formula composition of pH=6.5-7.0:

[0031]

[0032]

[0033] The preparation method of the staining liquid that is used for ocular surface staining comprises the following steps:

[0034] (1) At room temperature, add sodium fluorescein into a container filled with water according to the weight percentage, stir evenly, add 1% hydrochloric acid to adjust the pH value to 6.5-7.0;

[0035] (2) Then add polyacrylamide and sorbitol ester successively to the solution obtained in step (1) according to the weight percentage, and stir evenly for 25 minutes;

[0036] (3) Add Lissamine Green in weight percent to the solution obtained in step (2), then add dibutyl hydroxytoluene and benzalkonium chloride according to weight percent successively, and stir evenly for 30 minutes;

[0037] (4) The solution obtained in step (3) is filtered with a vacuum pump and a disposable filter to remove impurities and bacteria, and become a uniform dyeing solution; wherein the va...

Embodiment 2

[0040] Solution 2: Formula composition of pH=7.0-7.5:

[0041]

[0042]

[0043] The preparation method of the staining liquid that is used for ocular surface staining comprises the following steps:

[0044] (1) At room temperature, add sodium fluorescein into a container filled with water according to the weight percentage, stir evenly, add citric acid-sodium citrate solution to adjust the pH value to 7.0-7.5;

[0045] (2) Then add medical sodium hyaluronate, polyoxyethylene 40 hydrogenated castor oil to the solution obtained in step (1) according to the weight percentage, and stir evenly for 30 minutes;

[0046] (3) Add Lissamine Green in weight percent to the solution obtained in step (2), then add tert-butylhydroquinone and benzalkonium bromide in turn according to weight percent, and stir evenly for 25 minutes;

[0047] (4) The solution obtained in step (3) is filtered with a vacuum pump and a disposable filter to remove impurities and bacteria, and become a unifor...

Embodiment 3

[0050] Solution 3: Formula composition with pH=6.8~7.4

[0051]

[0052]

[0053] (1) At room temperature, add sodium fluorescein into a container filled with water according to the weight percentage, stir evenly, add sodium dihydrogen phosphate-disodium hydrogen phosphate solution to adjust the pH value to 6.8-7.4;

[0054] (2) then add polyvinyl alcohol 400, sodium sulfite, sodium sulfate successively in the solution that step (1) obtains according to weight percentage, then stir evenly for 50 minutes;

[0055] (3) Add Lissamine Green in weight percent to the solution obtained in step (2), then add xylitol and sorbitol successively according to weight percent, and stir evenly for 45 minutes;

[0056] (4) The solution obtained in step (3) is filtered with a vacuum pump and a disposable filter to remove impurities and bacteria, and become a uniform dyeing solution; wherein the vacuum pressure is 0.25MPa, and the membrane aperture of the disposable filter is 0.45 μm;

[00...

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Abstract

The invention relates to the technical field of medical supplies for ophthalmic clinical detection of ocular surface injury, and in particular relates to a staining solution for ocular surface staining and a preparation method thereof. The staining solution comprises fluorescein sodium, lissamine green, a stabilizer, an antioxidant, a protective agent, a pH regulator, a preservative and water; andthe fluorescein sodium and the lissamine green stably coexist for a long time. The staining solution for ocular surface staining disclosed by the invention is dropwise added into the ocular surface through a dropwise adding device; one-time staining of diagonal conjunctiva is completed at the same time; operation is easy; operation of an inspector is facilitated; and the staining solution for ocular surface staining disclosed by the invention is stable and does not fade along with time changes.

Description

technical field [0001] The invention relates to the technical field of medical supplies for clinical detection of ocular surface damage in ophthalmology, in particular to a staining solution for ocular surface staining and a preparation method thereof. Background technique [0002] Ocular surface staining is a convenient and effective method for diagnosing ocular surface diseases. Staining of the ocular surface is used to assess the integrity of the corneal and conjunctival epithelial cells, and dead cells or inactivated cells on the cornea and conjunctiva can be detected by staining. Some subtle changes in cornea and conjunctival epithelial cells can only be observed in vital staining. [0003] In the existing ocular surface dyeing technology, the dye is adsorbed on the filter paper to make a dye test strip. When in use, one or two drops of normal saline are dropped on one end of the dye test strip, and the liquid containing the dye Apply dropwise to the ocular surface ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/006
Inventor 刘铁梅
Owner TIANJIN JINGMING NEW TECH DEV CO LTD
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