Unlock instant, AI-driven research and patent intelligence for your innovation.

Drug sustained and controlled release platform system with dual nano composite structure

A nano-composite and nano-structure technology, which is applied in drug combination, drug delivery, respiratory diseases, etc., can solve the problems of prolonging the continuous administration time of a drug and reducing the number of drugs used by patients, so as to achieve high market application value and improve the accuracy of drug use Sexuality, the effect of reducing the number of medications

Inactive Publication Date: 2021-02-12
YANCHENG INST OF TECH
View PDF12 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the research on compounding nanofibers and nanoparticles to form a dual drug-loaded nanocomposite structure can further increase the specific surface area and drug loading rate of the drug-loading system, prolong the continuous administration time of a drug, and reduce the number of medications for patients. It is also possible to separately regulate the time and speed of drug release, improve the accuracy of drug use, and realize more controllable functions. There have been no relevant reports on this aspect of research, which is the content of the invention

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug sustained and controlled release platform system with dual nano composite structure
  • Drug sustained and controlled release platform system with dual nano composite structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Drug sustained and controlled release platform system with dual nanocomposite structure for oral administration with cancer treatment function

[0039] The electrospun nanofiber membrane is composed of a PCL / PLGA / paclitaxel composite nanofiber membrane loaded with the cancer chemotherapy drug paclitaxel; the nanoparticle is a composite nanoparticle of sodium alginate / calcium carbonate / doxorubicin loaded with the chemotherapy drug doxorubicin (DOX) grain. The drug-loaded nanofiber membrane and the drug-loaded nanoparticle are compounded by the nanoparticle in-situ generation method to obtain a drug sustained and controlled release system with a double nanocomposite structure with cancer treatment function. The drug-carrying system is placed in the cancerous lesion area in the body, and the separate release and graded release of the two drugs can be realized. Nanoparticles composed of sodium alginate / calcium carbonate / doxorubicin are easier to degrade, and dox...

Embodiment 2

[0040] Example 2: Drug sustained and controlled release platform system with dual nanocomposite structure for rapid drug delivery to oral mucosa

[0041] The electrospun nanofibrous membrane consists of a composite nanofibrous membrane of acrylic resin Eudragit / ethylcellulose (EC) / epinephrine hydrochloride loaded with asthma drug isoproterenol hydrochloride; Composite nanoparticles of chitosan / sodium alginate / calcium carbonate / clenbuterol; drug-loaded nanofibrous membranes and drug-loaded nanoparticles are compounded by nanoparticle in situ generation method, and obtained for oral mucosa The drug sustained and controlled release system with double nano-composite structure for rapid administration can realize the synergistic and rapid administration of the two materials. It is used for sublingual administration, the drug is absorbed quickly, the administration is convenient, and the oral first-pass effect is avoided. Significantly improved bioavailability.

Embodiment 3

[0042] Example 3: Drug sustained and controlled release platform system with double nanocomposite structure for gynecological inflammation treatment and embolism administration function

[0043] The electrospun nanofiber membrane is composed of a polyvinylpyrrolidone (PVP) / polyvinyl alcohol (PVA) / metronidazole composite nanofiber membrane loaded with the drug metronidazole for the treatment or prevention of systemic or local infections caused by anaerobic bacteria; The particles are graphene oxide / nano-silver composite nano drug-loading system. After the two are compounded by the padding process, a drug sustained and controlled release system with a double nanocomposite structure for the treatment of gynecological inflammation and rapid drug delivery to the vaginal mucosa can be obtained, which can realize the synergistic drug delivery of the two materials and regulate drug release. It is used for vaginal mucosa administration, which is convenient for administration and improv...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention provides a drug sustained and controlled release platform system with a double-nano composite structure in order to solve the problems that only one drug can be loaded in an existing drug delivery system, and the release rate of the drug cannot be effectively regulated and controlled due to the fact that several drugs are loaded into the same drug loading material. The nano-drug delivery system is used for in-vivo oral administration or in-vitro drug delivery, the same drug or different drugs can be respectively loaded into two nano-materials with different nano-structures in thesame drug delivery system, the specific surface area and the drug loading rate of the drug delivery system are further improved, the continuous drug delivery time of one-time drug delivery is prolonged, the drug delivery times of a patient are reduced, and the drug delivery efficiency is improved. The drug release speed can be respectively regulated and controlled, and the drug use accuracy is improved; the synergistic effect of the medicines is fully exerted, and the medicine sustained and controlled release function of the preparation material is fully exerted, so that a more ideal treatment effect is achieved.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a drug sustained and controlled release platform system with a double nanocomposite structure. Background technique [0002] With the development of nanomedicine, the focus of research tends to be nanomaterials, among which modified or modified nanofibers and nanoparticles with specific medical functions are the most widely studied. Today's pharmacy has entered the era of drug delivery systems (DDS), and various materials and technologies have been used in the research and development of new drug delivery systems. Based on the development of modern science and technology, especially materials science and pharmacy, the application of pharmacy is developing in depth. Drug-loaded fiber, that is, a new type of intermediate drug dosage form with fiber as a carrier, appears under this background. At present, many studies are trying to process drug-loaded fibers into DDS that can b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/32A61K47/36A61K47/34A61K47/38A61K47/42A61K47/02A61K45/00A61K31/704A61K31/137A61K31/4164A61P35/00A61P11/06A61P31/04A61P15/00
CPCA61K9/5169A61K9/5161A61K9/5153A61K9/5138A61K9/5115A61K9/0014A61K9/0053A61K9/006A61K45/00A61K31/704A61K31/137A61K31/4164A61P35/00A61P11/06A61P31/04A61P15/00
Inventor 吴焕岭王伟王丽丽
Owner YANCHENG INST OF TECH